Simultaneous determination of macaenes and macamides in maca using an HPLC method and analysis using a chemometric method (HCA) to distinguish maca origin

Xia, Chen; Deng, Junlin; Chen, Jian; Zhu, Yongqing; Zhang, Yingjiao; Li, Huajia; Lin, Changbin

doi:10.1016/j.bjp.2019.05.009

Cited by 19 publications

(21 citation statements)

References 25 publications

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“…Maca is a native plant that belongs to the Brassicaceae family [ [30] , [31] , [32] ]. Its hypocotyls are cultivated and consumed as native food and medicinal product [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Heavy metals in soils and edible tissues of Lepidium meyenii (maca) and health risk assessment in areas influenced by mining activity in the Central region of Peru

et al. 2021

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“…Maca is a native plant that belongs to the Brassicaceae family [ [30] , [31] , [32] ]. Its hypocotyls are cultivated and consumed as native food and medicinal product [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Heavy metals in soils and edible tissues of Lepidium meyenii (maca) and health risk assessment in areas influenced by mining activity in the Central region of Peru

et al. 2021

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“…The main phytochemicals found in Lepidium meyenii can be categorized into six classes: glucosinolates and isothiocyanates [54,59,63,[68][69][70][71][72], macaene and macamides [47,58,[73][74][75][76][77][78][79][80][81] , alkaloids [52,[82][83][84], thiohydantoins [85][86][87], polysaccharides [43,44,51,55,77,[88][89][90][91][92][93], and fatty acids [46,77,78,94,95]. Here, we discuss the in-depth contribution of polysaccharides to the nutraceutical properties of Lepidium meyenii.…”

Section: Phytochemicalsmentioning

confidence: 99%

Pharmacological Activities of the Nutraceutical Plant Lepidium meyenii: A Critical Review

Carvalho¹,

Ferraz²,

Ribeiro³

2020

J Food Chem Nanotechnol

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Lepidium meyenii is a medicinal edible plant that have nutritional and therapeutic benefits due to synthesis of bioactive compounds. The main phytochemicals found in Lepidium meyenii can be categorized into six classes: glucosinolates and isothiocyanates, thiohydantoins, macaene and macamides, alkaloids, polysaccharides, and fatty acids. These compounds show a wide range of biological activities, which include antioxidant, anti-inflammatory, antimicrobial, cytotoxic, and immunomodulatory activities. Hereby, the objective of this review is to provide a wide comprehension of the nutraceutical properties of Lepidium meyenii. For that, we review and critically discussed original manuscripts describing the chemical and nutritional composition, as well as biological activities of Lepidium meyenii extracts. We showed that the nutraceutical properties of the belowground part of Lepidium meyenii shows great variations that are dependent of differences of phenotype, place of cultivation, type of soil, environmental conditions, and time of harvest. Additionally, we have demonstrated that diet supplementation with Lepidium meyenii may exert several health prophylactics benefits.

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“…Macamides are believed to be found only in maca and considered as the bioactive marker compounds in maca [8]. Among the identified macamides, N-benzyl-9Z,12Z,15Z-octadecatrienamide, N-benzyl-9Z,12Z-octadecadienamide, and N-benzyl-hexadecanamide (macamide B) were the major macamide compounds [6].…”

Section: Macamide B Contentmentioning

confidence: 99%

“…Macamides are considered as biomarkers for maca, and the isolation and identification of macamides in maca have been studied extensively [5−7]. Xia et al [8] identified 7 macamides using a HPLC, which were 9-oxo-10E,12Z-octadecadienoicacid, 9-oxo-10E,12E-octadecadienoicacid, Nbenzyl-9-oxo-10E,12Z-octadecadienamide, N-benzyl-9oxo-10E,12E-octadecadienamide, N-benzyl-9Z,12Z,15Zoctadecatrienamide, N-benzyl-9Z,12Z-octadecadienamide, and N-benzyl-hexadecanamide. Among these identified macamides, N-benzyl-hexadecanamide (macamide B) was one of the major macamides and frequently served as a biomarker for maca [7,8].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant Activity, Macamide B Content and Muscle Cell Protection of Maca (Lepidium meyenii) Extracted Using Ultrasonification-Assisted Extraction

Buyanbadrakh¹,

Hong²,

Lee³

et al. 2020

Microbiology and Biotechnology Letters

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This study aims to evaluate the efficacy of the Ultrasonication-Assisted (UA) extraction on the functionality of the herbaceous biennial plant maca (Lepidium meyenii). The specific objectives include comparison of the antioxidant activities among various maca extracts, determination of the macamide B content of the extracts, and in vitro evaluation of maca on cell viability and creatine kinase (CK) activity. The antioxidant activities of the water, ethanol, and UA extracts were compared by determining the total phenolic and flavonoid contents, the 2, 2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activities, and the ferric reducing antioxidant power (FRAP) of the extracts. The macamide B content of maca extracts were analyzed by HPLC. The effects of the extracts on muscle cell viability and creatine kinase activity were also determined using C2C12 myoblasts. UA extraction significantly increased the total phenolic content (2.90 GAE µg/mg, p < 0.05), without affecting the flavonoid content. DPPH radical scavenging activity did not exhibit any statistical difference among the extracts. The ethanol and UA extracts exhibited significantly higher FRAP than the water extract (p < 0.05). The macamide B content of ethanol and UA extracts were 0.087 and 0.083 µg/mg, respectively. The water and UA extracts exhibited higher C2C12 muscle cell viability than the ethanol extract, and both extracts resulted in a significantly lower CK level than the H 2 O 2 -treated control group. This research suggests that the maca extract can protect muscle cells and serve as an antifatigue agent under oxidative stress conditions.

show abstract

Simultaneous determination of macaenes and macamides in maca using an HPLC method and analysis using a chemometric method (HCA) to distinguish maca origin

Cited by 19 publications

References 25 publications

Heavy metals in soils and edible tissues of Lepidium meyenii (maca) and health risk assessment in areas influenced by mining activity in the Central region of Peru

Heavy metals in soils and edible tissues of Lepidium meyenii (maca) and health risk assessment in areas influenced by mining activity in the Central region of Peru

Pharmacological Activities of the Nutraceutical Plant Lepidium meyenii: A Critical Review

Antioxidant Activity, Macamide B Content and Muscle Cell Protection of Maca (Lepidium meyenii) Extracted Using Ultrasonification-Assisted Extraction

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