Simultaneous determination of morphine and codeine using Pt nanoparticles supported on porous silicon flour modified ionic liquid carbon paste electrode

Ensafi, Ali A.; Abarghoui, Mehdi Mokhtari; Rezaei, Behzad

doi:10.1016/j.snb.2015.05.010

Cited by 54 publications

(17 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After the ionic liquid was incorporated with the carbon paste (IL/CPE), the semicircle clearly decreases presenting R ct equal to 2759 Ω due to the good conductivity of the ionic liquid. The same behavior was observed by Ensafi et al., in their work about the determination of morphine . The poly‐pPDs‐IL/CPE shows a low resistance compared to the other electrodes (1751 Ω), the electron transfer rate was then improved which can be attributed to the ionic liquid that act as polymerization catalyst .…”

Section: Resultsmentioning

confidence: 99%

Conducting Polymer/Ionic Liquid Composite Modified Carbon Paste Electrode for the Determination of Carbaryl in Real Samples

et al. 2018

View full text Add to dashboard Cite

A new method has been described for carbaryl determination using a simple electrochemical sensor. The unique properties of poly‐pPhenylenediamine and ionic liquid were exploited to fabricate carbon paste electrode modified with composite based on conducting polymer/ionic liquid. Electrode surface characterization was performed by electrochemical methods (cyclic voltammetry and electrochemical impedance spectroscopy) and by scanning electron microscopy. Differential pulse voltammetry was employed for the detection of carbaryl in acetate buffer solution. Different parameters affecting the carbaryl response were optimized such as ionic liquid amounts, cycle number of polymerization and monomer concentration, pH, and accumulation time. Under the optimum experimental conditions, a linear response was obtained between 0.5 and 200 μmol/L, with detection limit of 0.09 μmol/L. The developed sensor offered satisfactory results for carbaryl detection in spring water and fruit samples.

show abstract

Section: Resultsmentioning

confidence: 99%

Conducting Polymer/Ionic Liquid Composite Modified Carbon Paste Electrode for the Determination of Carbaryl in Real Samples

et al. 2018

View full text Add to dashboard Cite

show abstract

“…the slope of the calibration plot, resulted 2.61(0.09) nA/ppb, that is a value higher with respect to that found for different amperometric sensors reported so far by the literature (see Table 1). In this respect, it has to be underlined that higher sensitivity values were only found for modified electrodes exploiting adsorptive stripping as the detection technique [29,33]. However, this technique requires quite a long pre-concentration step under well-controlled stirring of the solution, which constitutes a condition that is not easy to adopt in portable and rapid sensor systems.…”

Section: Voltammetric Detection Of Morphine In Pbsmentioning

confidence: 99%

“…Particular attention should be directed to proteins, to hormones, and to a wide number of metabolites, urobilin included. Due to the presence of these components, several sample treatments are proposed by the literature [29,33,35,53], mainly based on centrifugation steps. However, this approach requires that the analysis is performed in a chemical laboratory.…”

Section: Morphine Detection In Urine Samplesmentioning

confidence: 99%

Highly sensitive amperometric sensor for morphine detection based on electrochemically exfoliated graphene oxide. Application in screening tests of urine samples

Maccaferri

Terzi

Xia

et al. 2019

Sensors and Actuators B: Chemical

View full text Add to dashboard Cite

Graphene oxide modified screen-printed electrodes have been tested as amperometric sensors for morphine determination. The results demonstrate that the arising of electrocatalytic processes ascribable to the graphene coating, combined with the use of a suitable cleaning procedure, allow the sensor to achieve higher sensitivity (2.61 nA ppb-1) and lower limit of detection (2.5 ppb) with respect to those reported in the literature for similar devices. Due to very low detection limit found, the device is suitable to detect the presence of morphine in urine samples after a very simple and rapid pre-treatment of the matrix, allowing the removal of interfering species affecting the voltammetric responses. Tests performed in synthetic urine samples demonstrate that the presence of the electrocatalytic coating is mandatory in resolving the peak due to morphine oxidation in respect to uric acid. The sensor proposed is, thus, suitable to detect this drug even at concentration values below the cutoff levels defined by European and American regulations. These results allow us to propose the sensor for screening tests in portable devices, to be applied in systematic controls of drug abuses, e.g. in drivers and in men at work.

show abstract

“…Various electrochemical, uorescence-based methods are favored using antibodies for the identication or quantication of opiates as they are highly sensitive, specic, and robust. [6][7][8][9] Previously, either polyclonal or monoclonal antibodies were used to conduct immunological assays for opiate drugs. [10][11][12] These methods were based on sandwich immunoassay for the detection of multivalent antigen.…”

Section: Introductionmentioning

confidence: 99%

A gold nanoparticle-single-chain fragment variable antibody as an immunoprobe for rapid detection of morphine by dipstick

et al. 2018

View full text Add to dashboard Cite

Gold nanoparticle (AuNP)-based optical assays are of significant interest since the molecular phenomenon can be examined easily with change in the color of AuNPs. Herein, we report the development of a dipstick using a AuNP-labeled single-chain fragment variable (scFv) antibody for the detection of morphine. The scFv antibodies for morphine were developed using phage display-based antibody library. Immunoglobulin variable regions of heavy (V H )-and light (V L )-chain genes were connected via a glycine-serine linker isolated from murine immune repertoire and cloned into the expression vector pIT2. The scFv was produced in Escherichia coli HB2151, yielding a functional protein with a molecular weight of approximately 32 kDa. The morphine scFv was labeled with gold nanoparticles and used as an optical immunoprobe in a dipstick. The competitive dipstick assay characterized the ability of the scFv antibody to recognize free morphine. The detection range was 1-1000 ng mL À1 with a limit of detection (LOD) of 5 ng mL À1 under optimal conditions, and the IC 50 value was 14 ng mL À1 for morphine. The developed optical dipstick kit of scFv antibody was capable of specifically binding to free morphine and its analogs in a solution in less than 5 min and could be useful for on-site screening of a real sample in blood, urine, and saliva.

show abstract

Simultaneous determination of morphine and codeine using Pt nanoparticles supported on porous silicon flour modified ionic liquid carbon paste electrode

Cited by 54 publications

References 44 publications

Conducting Polymer/Ionic Liquid Composite Modified Carbon Paste Electrode for the Determination of Carbaryl in Real Samples

Conducting Polymer/Ionic Liquid Composite Modified Carbon Paste Electrode for the Determination of Carbaryl in Real Samples

Highly sensitive amperometric sensor for morphine detection based on electrochemically exfoliated graphene oxide. Application in screening tests of urine samples

A gold nanoparticle-single-chain fragment variable antibody as an immunoprobe for rapid detection of morphine by dipstick

Contact Info

Product

Resources

About