Simultaneous determination of nicotine and 3-vinylpyridine in single cigarette tobacco smoke and in indoor air using direct extraction to solid phase

Koszowski, Bartosz; Goniewicz, Maciej Ł.; Czogała, Jan; Zymełka, Anna; Sobczak, Andrzej

doi:10.1080/03067310802549946

Cited by 13 publications

(10 citation statements)

References 12 publications

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“…1 Most analysis of ETS has been focused on an evaluation of the quality of indoor air, because it could be important to avoid a risk for non-smokers. 2,3 Of emerging concern is that pollutants from tobacco smoke not only remain during active smoking or second-hand smoke (SHS) but also cling to hair, skin, clothing, and furniture surfaces and are contained in dust; 4 these compounds from tobacco smoke have been defined as third-hand smoke (THS). 5,6 THS implies a residual contamination from tobacco smoke that remains after a cigarette is extinguished.…”

Section: Introductionmentioning

confidence: 99%

Detection of third-hand smoke on clothing fibers with a surface acoustic wave gas sensor

et al. 2016

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Third-hand smoke (THS) is a new cigarette-related issue defined as the residual contamination from cigarette smoke after a cigarette is extinguished. To detect THS on three commonly used clothing fibers-wool, cotton, and polyester, we applied two methods to measure the adsorption of THS: one was the gain of mass with an analytical balance after exposure to cigarette smoke; and the other was to detect the THS chemical compounds such as nicotine and 3-ethenylpyridine with a surface acoustic wave (SAW) sensor composed of coated oxidized hollow mesoporous carbon nanospheres. In the mass measurement, the gain of mass decreased in the order wool, cotton, and polyester; the latter gain was about one tenth that of wool. In the SAW detection, the frequency shift decreased in the same order-wool, cotton, and polyester. The residence period of THS on natural fiber (wool and cotton) is greater than on synthetic polyester fiber. These two tests provide quantitative results of THS on varied clothing fibers, to assess their risk after exposure to cigarette smoke.

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Section: Introductionmentioning

confidence: 99%

Detection of third-hand smoke on clothing fibers with a surface acoustic wave gas sensor

et al. 2016

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“…Due to the complex chemistry of tobacco smoke, differential distribution of the phases, and differences in bioavailability of the components, multiple tracers and biomarkers are desirable. 4,7,16–18 Nicotine, its metabolite cotinine, and the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) are the most specific of the commonly used biomarkers for tobacco smoke exposure. 16,19,20 Carbon monoxide, 16 metabolites of volatile organic compounds, 21 and PAH metabolites 22,23 are also useful biomarkers, but they have sources other than tobacco smoke.…”

Section: Introductionmentioning

confidence: 99%

Nicotelline: A Proposed Biomarker and Environmental Tracer for Particulate Matter Derived from Tobacco Smoke

Jacob

Goniewicz

Havel

et al. 2013

Chem. Res. Toxicol.

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Particulate matter (PM) derived from tobacco smoke contains numerous toxic substances. Since the PM and gas phase of tobacco smoke may distribute differently in the environment, and substances in them may have different human bioavailability, multiple tracers and biomarkers for tobacco smoke constituents are desirable. Nicotelline is a relatively non-volatile alkaloid present in tobacco smoke, and therefore it has the potential to be a suitable tracer and biomarker for tobacco smoke-derived PM. We describe experiments demonstrating that nicotelline is present almost entirely in the PM, in both freshly generated cigarette smoke and aged cigarette smoke. An excellent correlation between the mass of nicotelline and the mass of the PM in aged cigarette smoke was found. We also describe experiments suggesting that the main source of nicotelline in tobacco smoke is dehydrogenation of another little-studied tobacco alkaloid, anatalline, during the burning process. We show that nicotelline metabolites can be measured in urine of smokers, and that nicotelline can be measured in house dust from homes of smokers and non-smokers. We conclude that nicotelline should be useful as a tracer and biomarker for PM derived from tobacco smoke.

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“…Then nicotine was eluted with 3 mL of ethyl acetate and analysed with gas chromatograph Varian CP-3800 with capillary column CP-Sil 8CB 25 m×0.25 mm (1.2 μm) and FID detector (Varian Corporation, USA). The precision of the method was 9.78%, whereas the accuracy was 70.1% (based on the analyses of standardized vapours) (5). The limit of detection was 0.06 mg of nicotine per cigarette.…”

Section: Methodsmentioning

confidence: 91%

“…Nicotine in tobacco smoke was determined using a method described previously (5). Briefly, nicotine from cigarette smoke was extracted using solid sorbent tube with 0.5 g Porapak P (80-100 mesh).…”

Section: Methodsmentioning

confidence: 99%

Variations in Nicotine Yields between Single Cigarettes

Goniewicz

Koszowski²,

Czogała³

et al. 2012

Cent Eur J Public Health

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Introduction and Aims: It is beyond any doubt that nicotine yield in cigarettes as determined using standard ISO method bears almost no relation to smokers' actual intake. However, the ISO method is still in use in many countries where the government is responsible for controlling and monitoring cigarette quality. The aim of the study was to measure the nicotine yield in single cigarettes and to evaluate their statistical distribution among the same brand. Materials and methods: Nicotine yields were measured according to the ISO method in single cigarettes of the twenty most popular Polish brands of cigarettes. Results: Relative standard deviation of nicotine yields in single cigarettes of the same brands varied from 16% to 34%. Relative differences between nicotine yields in a single cigarette of a particular brand and the mean value varied from −65% to +76%. Discussion and Conclusions: The results indicate high variation in nicotine yields between cigarettes of the same brand. Such variation might affect compensatory smoking. This provides another reason why yields estimated using the standard ISO method are potentially misleading to smokers. Further studies are needed to better understand the implications of within-brand variability in yields for tobacco product regulation.

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Simultaneous determination of nicotine and 3-vinylpyridine in single cigarette tobacco smoke and in indoor air using direct extraction to solid phase

Cited by 13 publications

References 12 publications

Detection of third-hand smoke on clothing fibers with a surface acoustic wave gas sensor

Detection of third-hand smoke on clothing fibers with a surface acoustic wave gas sensor

Nicotelline: A Proposed Biomarker and Environmental Tracer for Particulate Matter Derived from Tobacco Smoke

Variations in Nicotine Yields between Single Cigarettes

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