Simultaneous determination of Nifuroxazide and Drotaverine hydrochloride in pharmaceutical preparations by bivariate and multivariate spectral analysis

Metwally, Fadia H

doi:10.1016/j.saa.2007.04.004

Cited by 22 publications

(13 citation statements)

References 18 publications

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“…A reference spectrophotometric method was adopted for the analysis of NF in pure form and in pharmaceutical preparation [19]. Statistical comparison of the results obtained by the proposed and reported methods is shown in Table 7.…”

Section: Resultsmentioning

confidence: 99%

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A validated spectrofluorimetric method for the determination of nifuroxazide through coumarin formation using experimental design

El‐Zaher

Mahrouse

2013

Chemistry Central Journal

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BackgroundNifuroxazide (NF) is an oral nitrofuran antibiotic, having a wide range of bactericidal activity against gram positive and gram negative enteropathogenic organisms. It is formulated either in single form, as intestinal antiseptic or in combination with drotaverine (DV) for the treatment of gastroenteritis accompanied with gastrointestinal spasm. Spectrofluorimetry is a convenient and sensitive technique for pharmaceutical quality control. The new proposed spectrofluorimetric method allows its determination either in single form or in binary mixture with DV. Furthermore, experimental conditions were optimized using the new approach: Experimental design, which has many advantages over the old one, one variable at a time (OVAT approach).ResultsA novel and sensitive spectrofluorimetric method was designed and validated for the determination of NF in pharmaceutical formulation. The method was based upon the formation of a highly fluorescent coumarin compound by the reaction between NF and ethylacetoacetate (EAA) using sulfuric acid as catalyst. The fluorescence was measured at 390 nm upon excitation at 340 nm. Experimental design was used to optimize experimental conditions. Volumes of EAA and sulfuric acid, temperature and heating time were considered the critical factors to be studied in order to establish an optimum fluorescence. Each two factors were co-tried at three levels. Regression analysis revealed good correlation between fluorescence intensity and concentration over the range 20–400 ng ml-1. The suggested method was successfully applied for the determination of NF in pure and capsule forms. The procedure was validated in terms of linearity, accuracy, precision, limit of detection and limit of quantification. The selectivity of the method was investigated by analysis of NF in presence of the co-mixed drug DV where no interference was observed. The reaction pathway was suggested and the structure of the fluorescent product was proposed. Statistical comparison between the presented method and a reported spectrophotometric one was carried out on pure and pharmaceutical formulation and revealed no significant difference.ConclusionThe proposed method was considered economic, accurate, precise and highly sensitive. It could be easily applied in laboratory quality control for the analysis of NF in pure form and in pharmaceutical dosage form.

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Section: Resultsmentioning

confidence: 99%

“…Pharmaceutical dosage form containing a binary mixture of NF and drotaverine ( DV , Scheme 1b), is well established as an intestinal antiseptic - antispasmodic formulation. Spectrophotometric, TLC and HPLC [19-21] methods were developed for the simultaneous determination of NF and DV in capsules.…”

Section: Introductionmentioning

confidence: 99%

A validated spectrofluorimetric method for the determination of nifuroxazide through coumarin formation using experimental design

El‐Zaher

Mahrouse

2013

Chemistry Central Journal

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“…Hence, the aim of this work is to develop three spectrophotometric methods for simultaneous determination of SAC and VAL in their pharmaceutical tablets. The developed methods are bivariate method (BM) [15][16][17][18][19] , classical least square (CLS) and principal component regression (PCR) [20][21][22][23] .…”

Section: Entrestomentioning

confidence: 99%

Simultaneous Spectrophotometric Determination of Sacubitril and Valsartan in their Recently Approved Pharmaceutical Preparation

Attia

Nassar

El‐Olemy

et al. 2018

Journal of Advanced Pharmacy Research

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Objectives: Simultaneous estimation of sacubitril and valsartan in their new pharmaceutical tablets by bivariate method and two multivariate methods namely; classical least square and principal component regression. Methods: (A) Bivariate method, where absorbance values were measured at two optimum wavelengths (220 nm and 250 nm). (B) Multivariate methods, where partial factorial design was constructed within the wavelength range from 210-290nm at 1 nm interval. Results: The bivariate method is based on simple mathematic algorithm using two optimum wavelengths for the analysis of the mixture. On the other hand, two multivariate methods considering all the variables at the same time have been used to improve the quality of spectral analysis of the mixture. Conclusion: The proposed methods have been successfully applied for the determination of the two drugs in Entresto ® tablets. Statistical comparisons between the obtained results and those obtained by the reported method have been performed showing no significant differences by applying t-test and F-test.

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“…However, there has been no paper reporting the metabolism and residue depletion of NFX in animal so far. There have been only several papers reporting the determination of NFX in feeds and pharmaceutical preparations . Leitner et al .…”

Section: Introductionmentioning

confidence: 99%

“…There have been only several papers reporting the determination of NFX in feeds 22,24 and pharmaceutical preparations. [26][27][28] showed that the metabolism of nitrofuran drug was through the cleavage of the nitrofuran ring, leaving the specific tail group covalently bound to tissue. 21 As shown in Fig.…”

Section: Introductionmentioning

confidence: 99%

Residue depletion of nifuroxazide in broiler chicken

Gao

Zhang

et al. 2013

J Sci Food Agric

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Simultaneous determination of Nifuroxazide and Drotaverine hydrochloride in pharmaceutical preparations by bivariate and multivariate spectral analysis

Cited by 22 publications

References 18 publications

A validated spectrofluorimetric method for the determination of nifuroxazide through coumarin formation using experimental design

A validated spectrofluorimetric method for the determination of nifuroxazide through coumarin formation using experimental design

Simultaneous Spectrophotometric Determination of Sacubitril and Valsartan in their Recently Approved Pharmaceutical Preparation

Residue depletion of nifuroxazide in broiler chicken

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