Simultaneous determination of phenoxyethanol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC–MS/MS with polarity switching: Application to ADME studies

Kim, So Yeon; Kim, Min Gi; Kim, Min; Shin, Beom Soo; Kim, Kyu‐Bong; Lee, Jong Bong; Paik, Soo Heui; Yoo, Sun Dong

doi:10.1016/j.talanta.2015.05.075

Cited by 22 publications

(15 citation statements)

References 21 publications

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“…In 2015, a research team used a physiologically based pharmacokinetic (PBPK) model to predict the systemic availability of phenoxyethanol in rats and humans. However, the results of this PBPK model were not considered to be relevant by the SCCS due to the following reasons: Results for rats obtained using the PBPK model were underestimated compared to those obtained from a ‘real’ study conducted in rats; Results in humans could not be compared with ‘real’ data [observed area under the curve (AUC) of either phenoxyethanol or 2‐phenoxyacetic acid compared to their predicted AUC], thus limiting the validity of this PBPK model. …”

Section: Review Of Safety Datamentioning

confidence: 99%

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Safety review of phenoxyethanol when used as a preservative in cosmetics

Dréno

Zuberbier

Gelmetti

et al. 2019

Acad Dermatol Venereol

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Phenoxyethanol, or 2‐phenoxyethanol, has a large spectrum of antimicrobial activity and has been widely used as a preservative in cosmetic products for decades. It is effective against various Gram‐negative and Gram‐positive bacteria, as well as against yeasts, and has only a weak inhibitory effect on resident skin flora. According to the European Scientific Committee on Consumer Safety, phenoxyethanol is safe for all consumers – including children of all ages – when used as a preservative in cosmetic products at a maximum concentration of 1%. Adverse systemic effects have been observed in toxicological studies on animals but only when the levels of exposure were many magnitudes higher (around 200‐fold higher) than those to which consumers are exposed when using phenoxyethanol‐containing cosmetic products. Despite its widespread use in cosmetic products, phenoxyethanol is a rare sensitizer. It can be considered as one of the most well‐tolerated preservatives used in cosmetic products.

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Section: Review Of Safety Datamentioning

confidence: 99%

“…Numerous in vivo kinetic studies using oral and topical routes have been conducted in animals, as well as in humans . These studies showed that phenoxyethanol is rapidly absorbed, distributed, metabolized and excreted.…”

Section: Review Of Safety Datamentioning

confidence: 99%

Safety review of phenoxyethanol when used as a preservative in cosmetics

Dréno

Zuberbier

Gelmetti

et al. 2019

Acad Dermatol Venereol

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“…Ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) integrates the superior separation potential of UHPLC along with the excellent specific and sensitive detection of MS/MS; hence, it is unsurprising that UHPLC-MS/MS can serveas a workhorse for the simultaneous determination of dozens of analytes in complicated matrices, e.g., plasma [ 16 ], feces [ 17 , 18 ], urine [ 19 ], etc. In general, a large array of components can be generated in vivo following oral administration of a given TCM.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Twenty-Five Compounds in Rat Plasma Using Ultra-High Performance Liquid Chromatography-Polarity Switching Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study

Zhang

Sun

et al. 2017

Molecules

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An attempt was made to characterize the pharmacokinetic profiles of Qishen Keli (QSKL) that has been widely proved to be effective in clinical practice. A method using ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) for the simultaneous determination of 25 analytes in rat plasma was developed and validated. Satisfactory chromatographic separation was achieved on an ACQUITY UPLC HSS T3 column with gradient elution using mobile phase consisting of 0.02% aqueous formic acid (A) and acetonitrile fortified with 0.02% formic acid (B), and analyte detection was carried out using polarity-switching multiple reaction monitoring mode. Method validation assays in terms of selectivity, linearity, inter- and intra-day variations, matrix effect, and recovery demonstrated the newly developed method to be specific, sensitive, accurate, and precise. Following the oral administration of QSKL at a single dose, the qualified method was successfully applied for pharmacokinetic investigations in sham and model rats. Mild differences occurred for the pharmacokinetic patterns of most components between those two groups, whereas significant differences were observed for glycyrrhizic acid and glycyrrhetic acid. The obtained findings could provide meaningful information for the clarification of the effective material basis of QSKL.

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“…2-phenoxyethanol has been extensively used in the manufacturing of detergents, cosmetics, printing boards, and inks due to its low toxicity and excellent dissolving capacity. 22 In addition, 2-phenoxyethanol is used to dissolve both phenoxy resins and cellulose. In particular, it has been reported that 2-phenoxyethanol can be used as a dyeing carrier and pre-treatment agent for aromatic fibers.…”

mentioning

confidence: 99%

Effect of 2-phenoxyethanol pre-treatment on structure and adhesion properties of thermotropic liquid crystal polyarylate fibers

Chen

Liu

Sheng

et al. 2021

Textile Research Journal

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This study investigated the surface modification of thermotropic liquid crystal polyarylate (TLCP) fibers by 2-phenoxyethanol pre-treatment, specifically, whether it enhanced their interfacial adhesive properties. The surface chemical compositions and microstructures of both control and 2-phenoxyethanol pre-treated TLCP fibers were characterized by X-ray photoelectron spectroscopy, scanning electron microscopy, and atomic force microscopy. Furthermore, thermal, dyeing, and adhesion properties of both control and 2-phenoxyethanol pre-treated fibers were compared by thermogravimetric analysis, colorimetry, and universal material testing system, respectively. The results indicated that 2-phenoxyethanol pre-treatment increased the surface-anchored oxygen atom amount: the oxygen to carbon atomic ratio at the surface of the TLCP fibers increased from 0.17 to 0.22. However, 2-phenoxyethanol pre-treatment showed almost no effect on the thermal stability and mechanical properties of the TLCP fibers. The peeling strength of the 2-phenoxyethanol pre-treated TLCP fabric was around twice that of the control TLCP fabric.

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Simultaneous determination of phenoxyethanol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC–MS/MS with polarity switching: Application to ADME studies

Cited by 22 publications

References 21 publications

Safety review of phenoxyethanol when used as a preservative in cosmetics

Safety review of phenoxyethanol when used as a preservative in cosmetics

Simultaneous Determination of Twenty-Five Compounds in Rat Plasma Using Ultra-High Performance Liquid Chromatography-Polarity Switching Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study

Effect of 2-phenoxyethanol pre-treatment on structure and adhesion properties of thermotropic liquid crystal polyarylate fibers

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