2016
DOI: 10.2116/analsci.32.981
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Simultaneous Determination of Seven Neuroactive Steroids Associated with Depression in Rat Plasma and Brain by High Performance Liquid Chromatography?Tandem Mass Spectrometry

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Cited by 5 publications
(8 citation statements)
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“…However, it is recommended to use the matrix surrogate calibration curve for the analysis of metabolites in biological samples. 86 Compared to many available studies, LLOQ values for T, 34,39,47,81,82,85 DHEA, 35,39,41,45,47,81,82,85 PROG, 35,39,41,44,47 PREG, 39,47 ANDRO, 39,41,81,82,85 ALLO, 88,89 and DHT 39 were better or at least within 1 order of magnitude. Lower quantification limits for some substances in other methods may be due to the use of different ionization techniques.…”
Section: Chromatographic Separation and Mass Spectrometric Detectionmentioning
confidence: 88%
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“…However, it is recommended to use the matrix surrogate calibration curve for the analysis of metabolites in biological samples. 86 Compared to many available studies, LLOQ values for T, 34,39,47,81,82,85 DHEA, 35,39,41,45,47,81,82,85 PROG, 35,39,41,44,47 PREG, 39,47 ANDRO, 39,41,81,82,85 ALLO, 88,89 and DHT 39 were better or at least within 1 order of magnitude. Lower quantification limits for some substances in other methods may be due to the use of different ionization techniques.…”
Section: Chromatographic Separation and Mass Spectrometric Detectionmentioning
confidence: 88%
“…42,44,51,57 NASs are studied by LC−MS/MS in various types of mammalian biological matrices such as plasma or serum, 13,22,34,41,43,47−49 the cerebrospinal fluid, 13,31,43 and brain tissues. 47,50,51 However, others can also be used: urine, 52,53 saliva, 42,54,55 hair, 46,56 or nails. 57 LC−MS/MSbased methods have been successfully used to determine selected representatives of androgens, estrogens, progestins, and corticosteroids.…”
Section: Introductionmentioning
confidence: 99%
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“…For example, pregnenolone, progesterone, and 5α-dihydrotestosterone levels were increased, and in 5α-dihydroprogesterone and allopregnanolone, levels were decreased in patients with multiple sclerosis compared to the control group. In another study, chromatographic separation of the samples performed on a PR-C18 column was combined with an MS/MS analyzer using the positive mode of APCI and SRM transitions [109]. A simple and specific method has been developed for simultaneous determination of selected NASs, namely cortisone, cortisol, DHEA, estradiol, progesterone, pregnenolone, and testosterone.…”
Section: Lc-ms Applications In Steroid Analysismentioning
confidence: 99%