2012
DOI: 10.1080/10826076.2011.615087
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Simultaneous Determination of Sulfamethoxazole and Trimethoprim in Rat Plasma by Lc-Esi-MS and Its Application to a Pharmacokinetic Study

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Cited by 3 publications
(4 citation statements)
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“…However, the use of LC-MS/MS has several advantages above HPLC-UV, such as a higher specificity, sensitivity and an easier sample preparation. Only Methodology Dijkstra, Alsaad, van Hateren, Greijdanus, Touw & Alffenaar three papers could be retrieved addressing the validation of the analysis of co-trimoxazole in serum using LC-MS/MS [20][21][22]. Unfortunately, all three papers did not include the validation of sulfamethoxazole-Nacetyl, the toxic metabolite of sulfamethoxazole.…”
Section: Discussionmentioning
confidence: 99%
“…However, the use of LC-MS/MS has several advantages above HPLC-UV, such as a higher specificity, sensitivity and an easier sample preparation. Only Methodology Dijkstra, Alsaad, van Hateren, Greijdanus, Touw & Alffenaar three papers could be retrieved addressing the validation of the analysis of co-trimoxazole in serum using LC-MS/MS [20][21][22]. Unfortunately, all three papers did not include the validation of sulfamethoxazole-Nacetyl, the toxic metabolite of sulfamethoxazole.…”
Section: Discussionmentioning
confidence: 99%
“…Although many of the earlier papers reported on the pharmacokinetics of sulfonamides or TMP using fluorimetric assays, 15,16,21 in recent papers, the state-of-the-art technology has been liquid chromatography/tandem mass spectrometry (LC/MS/MS), resulting in considerably lower limits of detection between 10 and 100 ng/ mL. [22][23][24] The aim of the present study was to compare metabolism and detection time windows of SDO, TMP and metabolites in plasma and urine after a single intravenous dose of 2.7 mg/kg TMP and 13.4 mg/ kg SDO with a sensitive LC/MS/MS method in order to implement a reasonable detection method to control the misuse of these antibiotics in sport horses. Afterwards, a solid-phase extraction (SPE) of urine and plasma samples was conducted by means of Oasis ® HLB SPE cartridges (60 mg, 3 mL), which were conditioned with 1 mL of methanol and 1 mL of ultrapure water.…”
Section: Introductionmentioning
confidence: 99%
“…Although many of the earlier papers reported on the pharmacokinetics of sulfonamides or TMP using fluorimetric assays, 15,16,21 in recent papers, the state‐of‐the‐art technology has been liquid chromatography/tandem mass spectrometry (LC/MS/MS), resulting in considerably lower limits of detection between 10 and 100 ng/mL 22–24 …”
Section: Introductionmentioning
confidence: 99%
“…A study was reported for the determination of Sulfonamides in milk samples using LCMS (Unsal et al, 2018). However a method for determining Sulfamethoxazole and Trimethoprim in rat plasma using Estazolam as Internal standard was proposed in LCMS (Wang et al, 2012). In LCMS, ten sulfonamides in eggs were studied (de la Cruz et al, 2011).…”
Section: Introductionmentioning
confidence: 99%