Simultaneous determination of ten compounds in two main medicinal plant parts of Tibetan herb, &lt;i&gt;Pterocephalus hookeri&lt;/i&gt; (CB Clarke) Höeck, by ultra-high performance liquid chromatography-photodiode array

Tang, Ce; Fan, Gang; Li, Qi; Su, Jinsong; Meng, Xianli; Yi, Zhang

doi:10.4314/tjpr.v16i6.27

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…Currently, it was considered that iridoids were the main anti-inflammatory constituents in this herb [ 6 ]. Sweroside, isolated and identified from P. hookeri [ 7 ], was a typical iridoid that exhibits diverse biological activities, such as hepatoprotective [ 8 ], antidiabetic [ 9 ] and anti-inflammatory [ 10 ] effects.…”

Section: Introductionmentioning

confidence: 99%

Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells

et al. 2019

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Pterocephalus hookeri was used as a traditional Chinese medicine for the treatment of rheumatoid arthritis. Sweroside was a main iridoid isolated from P. hookeri. The present study aimed to investigate the anti-inflammatory effect mechanism of sweroside. In RAW264.7 cells induced by lipopolysaccharide (LPS), the abnormal proliferation, the NO content increase, and the downregulated Sirtuin1 (SIRT1) expression were observed. Sweroside could alleviate the inflammation by inhibiting cell proliferation through arresting the cell cycle at the G0/G1 phase, by suppressing pro-inflammatory cytokines and by promoting anti-inflammatory cytokines in LPS-induced RAW264.7 cells. Further mechanism research indicated that sweroside could activate the SIRT1, then suppress the nuclear factor-kappa B (NF-κB) and promote the Forkhead transcription factor O1 (FOXO1) signaling pathways. The present study indicated that sweroside may be the main anti-inflammatory constituent of P. hookeri and a promising candidate for anti-inflammation therapy.

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Section: Introductionmentioning

confidence: 99%

Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells

et al. 2019

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“…Previous studies have confirmed that the major chemical components of P. hookeri include iridoid glycosides, triterpenoid saponins, and phenolic acids [5,6]. A survey of ancient literature revealed that P. hookeri was frequently used in the treatment of RA [7].…”

Section: Introductionmentioning

confidence: 99%

Network pharmacology and UPLC-Q-TOF/MS studies on the anti-arthritic mechanism of <i>Pterocephalus hookeri</i>

Tang¹,

Li²,

Fan³

et al. 2018

Trop. J. Pharm Res

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Purpose: To investigate the mechanism underlying the anti-arthritic properties of Pterocephalus hookeri used for treatment of rheumatoid arthritis (RA). Methods: Aqueous methanol extract of P. hookeri was analyzed using UPLC-Q-TOF/MS, a Waters Acquity UPLCR BEH C18 column (2.1 × 100 mm, 1.7 μm) and gradient elution with acetonitrile-formic acid-water. Targets and related pathways were predicted by PharmMapper database and Molecule Annotation System, respectively. The network was built with Cytoscape software. Results: Forty compounds were identified, comprising 17 iridoid glycosides, 7 phenolic acids, 13 triterpenes, and 3 other compounds. A total of 38 targets and 44 pathways associated with RA were obtained. These involved mainly MAPK signaling pathway, adherens junction, and colorectal cancer. Conclusion: These results from network pharmacology suggest that P. hookeri exerts therapeutic effect on RA via multiple components, multiple targets and multiple pathways.

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High-Performance Liquid Chromatography for Analysis of Herbal Drugs

Mukherjee

2019

Quality Control and Evaluation of Herbal Drugs

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Simultaneous determination of ten compounds in two main medicinal plant parts of Tibetan herb, <i>Pterocephalus hookeri</i> (CB Clarke) Höeck, by ultra-high performance liquid chromatography-photodiode array

Abstract: Purpose: To develop an ultra-high performance liquid chromatography (UPLC) -photodiode array (PDA)

Cited by 4 publications

References 13 publications

Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells

Sweroside Alleviated LPS-Induced Inflammation via SIRT1 Mediating NF-κB and FOXO1 Signaling Pathways in RAW264.7 Cells

Network pharmacology and UPLC-Q-TOF/MS studies on the anti-arthritic mechanism of <i>Pterocephalus hookeri</i>

High-Performance Liquid Chromatography for Analysis of Herbal Drugs

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