Simultaneous determination of triamcinolone acetonide and oxymetazoline hydrochloride in nasal spray formulations by HPLC

Oxymetazoline adds to the effectiveness of fluticasone furoate in the treatment of perennial allergic rhinitis

“…In addition to being an a-agonist, oxymetazoline has been shown to have various antioxidative and anti-inflammatory properties. [8][9][10][11][12] Whether any of these effects contributed to our results is unknown. The oxymetazoline was dosed once daily at night.…”

Advances in the analysis of steroid hormone drugs in pharmaceuticals and environmental samples (2004–2010)

“…These stability-indicating methods are almost exclusively RP-HPLC methods with UV detection. The determination of betamethasone [67], betamethasone dipropionate [68], budesonide [69], clobetasol propionate [70], deflazacort [71], dexamethasone [71][72][73][74], dexamethasone acetate [75], dexamethasone sodium phosphate [72,76], diflucortolone valerate [77], dutasteride [19], eplerenone [18], estradiol [21,78,79], ethinylestradiol [80], fluocinolone acetonide [81], finasteride [82], fluticasone propionate [83], gestodene [80], medroxyprogesterone acetate [14], meprednisone [84], mometasone furoate [85], testosterone propionate and cypionate [86] and triamcinolone acetonide [87] in various solid, semi-solid and liquid formulations have been described. The on-line assay of beclomethasone propionate pressurized metered dose inhalers [88] and the determination of the solubility of beclomethasone propionate [89] and budesonide [90] in the same device are also worth mentioning.…”

Development and Utilization of Reversed Phase High Performance Liquid Chromatography Methods for a Series of Therapeutic Agents

“…It is generally used in the nasal cavity as a decongestant [25,26] and can be used in combination therapies for a wide variety of ear, nose and throat disorders [25][26][27]. The drug has a relatively low molecular weight, much of which is contained within the chromophore structure itself.…”

“…This drug is often used in ointments and sprays and therefore ability to quantify release through HPLC is of great value. Analysis is traditionally performed using a C18 column with detection at 230 nm [25][26][27].…”