Simultaneous dual-band ultra-high resolution optical coherence tomography

Abstract

Ultra-high resolution optical coherence tomography (OCT) imaging is demonstrated simultaneously at 840 nm and 1230 nm central wavelength using an off-the-shelf turn-key supercontinuum light source. Spectral filtering of the light source emission results in a double peak spectrum with average powers exceeding 100 mW and bandwidths exceeding 200 nm for each wavelength band. A free-space OCT setup optimized to support both wavelengths in parallel is introduced. OCT imaging of biological tissue ex vivo and in vivo is demonstrated with axial resolutions measured to be < 2 mum and < 4 mum at 840 nm and 1230 nm, respectively. This measuring scheme is used to extract spectroscopic features with outstanding spatial resolution enabling enhanced image contrast.

Cellular Level Imaging of the Retina Using Optical Coherence Tomography

“…Another dual band OCT imaging was demonstrated with 840 and 1230 nm center wavelength with 1060 nm pump wavelength (Spoler et al, 2007). The spectral shape of the supercontinuum source was tailored with a double pass prism, razor blades and an end mirror (Spoler et al, 2007).…”

“…The spectral shape of the supercontinuum source was tailored with a double pass prism, razor blades and an end mirror (Spoler et al, 2007). Resulting bandwidths were > 200 nm after spectral filtering with > 100 mW average power for each wavelength (Spoler et al, 2007).…”

“…Resulting bandwidths were > 200 nm after spectral filtering with > 100 mW average power for each wavelength (Spoler et al, 2007). The source was incorporated in a free space OCT system to launch both wavelengths simultaneously (Spoler et al, 2007). Dichroic filters separated the two wavelength channels prior to detection (Spoler et al, 2007).…”

“…The source was incorporated in a free space OCT system to launch both wavelengths simultaneously (Spoler et al, 2007). Dichroic filters separated the two wavelength channels prior to detection (Spoler et al, 2007). In-vitro OCT imaging of a rabbit eye was performed and showed axial resolutions <2 and < 4 um at 840 and 1230 nm in tissue, respectively (Spoler et al, 2007).…”

Three-band, 19-μm axial resolution full-field optical coherence microscopy over a 530–1700 nm wavelength range using a single camera

“…High-resolution FF-OCM [7] and conventional OCT [8] were demonstrated in two bands, at ∼800 nm and ∼1200 nm center wavelengths, using, respectively, a halogen lamp and a supercontinuum laser as broadband light sources and two different detectors. Even though imaging can be performed simultaneously in the two bands, these approaches are not technologically convenient for multiband imaging since each band requires a dedicated detector.…”