Simultaneous dual-radionuclide myocardial perfusion imaging with a solid-state dedicated cardiac camera

Ben‐Haim, Simona; Kacperski, Krzysztof; Hain, Sharon F.; Gramberg, Dean Van; Hutton, Brian F.; Erlandsson, Kjell; Sharir, Tali; Roth, Nathaniel; Waddington, W; Berman, Daniel S.; Ell, Peter J.

doi:10.1007/s00259-010-1441-1

Cited by 99 publications

(55 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These CZT detectors provide a dramatic improvement in image quality and, in addition, facilitate dual isotope recordings such as those involving 201 Tl and 99m Tc-labeled tracers. 7,8 However, the two CZT cameras are based on clearly different collimation systems. This constitutes the main reason why the characteristics of the myocardial perfusion images provided by these two cameras are significantly different, as confirmed by the study of Zoccarato et al 4 The Discovery NM530c camera is based on a stationary multi-pinhole collimation system.…”

Section: See Related Article Pp 885-893mentioning

confidence: 99%

CZT cameras: A technological jump for myocardial perfusion SPECT

Imbert

Marie

2016

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

Section: See Related Article Pp 885-893mentioning

confidence: 99%

CZT cameras: A technological jump for myocardial perfusion SPECT

Imbert

Marie

2016

Journal of Nuclear Cardiology

View full text Add to dashboard Cite

“…The use of CZT provides potential for superior energy discrimination that may encourage increased use of simultaneous dual or multiple radionuclide studies; these not only provide efficient patient protocols but reduce the need for interstudy registration due to patient movement. The simultaneous use of 99m Tc and 201 Tl for simultaneous rest/stress myocardial perfusion imaging has been recently demonstrated for the D-SPECT system [18]. An advantage of the higher sensitivity systems is the ability to reduce the activity of the 99m Tc-labelled tracer so as to reduce down-scatter to the lower energy photopeak.…”

Section: Extended Applicationsmentioning

confidence: 99%

New SPECT technology: potential and challenges

Hutton

2010

Eur J Nucl Med Mol Imaging

Self Cite

View full text Add to dashboard Cite

Potential Major advances in organ-specific imagingThe article by Bocher et al. in this issue [1] reports on the performance of a novel SPECT system specifically designed for cardiac imaging based on the use of a set of pinhole collimators in combination with cadmium zinc telluride (CZT) detectors. The system is inspired by earlier work on multipinhole imaging [2] and the conceptual design has previously been demonstrated in simulation studies [3]. Also early clinical validation studies have appeared recently [4,5]. The described system (available from GE Healthcare) joins a range of novel organ-specific commercial systems that have recently been introduced to the consumer with reported improvement in resolution and sensitivity (usually reported as potential for reduced acquisition time; see recent reviews [6,7]). Specific examples are the D-SPECT from Spectrum Dynamics [8,9] and the Cardius from Digirad [10]. Clinical validation studies for these systems are now also appearing (e.g. [11,12]). The developers of these systems deserve congratulations for introducing innovations that undoubtedly yield the largest advance in SPECT performance since the introduction of the rotating gamma camera, which has dominated clinical use for several decades. Until recently the development in SPECT performance has been incremental, mainly involving refinement rather than major changes in system design, perhaps mainly due to the clinical demand for systems that offer flexibility in application. The recent innovation has been inspired at least partly by the rapid developments in preclinical imaging systems where ultrahigh resolution and relatively high sensitivity have been demonstrated. Bringing new designs to fruition has only been possible due to the combination of several factors: the improved reliability of alternative detector materials, the development of fast electronics, the development of efficient reconstruction algorithms and, not least, the demand for organ-specific systems where optimization for a specific purpose rather than flexibility in application is indicated. CZT: pros and consCentral to the design of both the GE Healthcare system and the D-SPECT is the use of CZT. Although not a new detector material, it is only recently that the reliability and performance of CZT at room temperature have been sufficiently improved to make clinical use a possibility. The cost of CZT remains relatively high and places a constraint on the possible designs. But the appeal is not just the much improved energy resolution (typically 5-6%) but particularly the small size that facilitates novel compact designs, which are very much appealing for use in organspecific imaging. There are alternative approaches to achieving compact designs based on conventional scintillation detectors coupled to optical readout systems other than conventional photomultiplier tubes (e.g. avalanche photodiode or silicon photomultiplier), which may have a cost advantage (see [13] for a useful overview). We can anticipate increasing use of new technology in f...

show abstract

“…The dedicated solid-state cardiac camera used by Ben-Haim et al [3] in their study published in this issue of the European Journal of Nuclear Medicine and Molecular Imaging represents an important answer to the above-mentioned clinical needs for nuclear MPI.…”

mentioning

confidence: 99%

“…In this cardiac camera, the detectors and collimators do not move during image acquisition and all lines of response are acquired simultaneously through a proprietary multi-pinhole collimator. Also the D-SPECT camera (Spectrum Dynamics) employed by Ben-Haim et al [3] uses solid-state detectors in the form of CZT, which improves the energy and spatial resolutions, thus facilitating the development of simultaneous dualisotope imaging protocols. The pixilated CZT detector arrays are mounted in nine vertical columns and placed in a 90°gantry geometry.…”

mentioning

confidence: 99%