2017
DOI: 10.20959/wjpps20177-9561
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Simultaneous Estimation of Sacubitril and Valsartan in Pharmaceutical Dosage Form by Development and Validation of Stability Indicating Chromatographic Method

Abstract: This study aims to develop and validate a stability indicating HPLC method for simultaneous estimation of sacubitril and valsartan in pharmaceutical dosage form. Sacubitril and valsartan separation was achieved by LC-20 AT C 18 (250mm x 4.6 mm) column and buffer (potassium phosphate, pH 3.0): methanol (50:50) as mobile phase, at a flow rate of 1 ml/min (milliliter per minute). Detection was carried out at 224 nm (nanometer). The different HPLC experimental parameters were optimized and the method was validated… Show more

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Cited by 9 publications
(2 citation statements)
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“…It is interesting to observe HPLC had been continuously used in development of stability indicating studies of sacubitril and valsartan ( Ahmed et al., 2017 ; Patel et al., 2017 ; Mishara et al., 2017 ; Naazneen and Sridevi, 2017 ; Jyothi and Umadevi, 2018 ; Moussa et al., 2018 ). Various combinations of mobile phases were used to achieve better separation for sacubitril, valsartan and their impurities.…”
Section: Stability Indicating Assaysmentioning
confidence: 99%
“…It is interesting to observe HPLC had been continuously used in development of stability indicating studies of sacubitril and valsartan ( Ahmed et al., 2017 ; Patel et al., 2017 ; Mishara et al., 2017 ; Naazneen and Sridevi, 2017 ; Jyothi and Umadevi, 2018 ; Moussa et al., 2018 ). Various combinations of mobile phases were used to achieve better separation for sacubitril, valsartan and their impurities.…”
Section: Stability Indicating Assaysmentioning
confidence: 99%
“…The primary matter of valsartan, valeryl 4-hydroxy valsartan, has no medicine activity. Literature search reveals that only two analytical methods were reported for simultaneous estimation of sacubitril and valsartan from rat plasma using LC-MS/MS and from a synthetic mixture using HPLC [12][13][14][15][16][17][18][19][20]. Hence a simple, rapid, sensitive and accurate stability indicating HPLC method was developed for the simultaneous estimation of sacubitril and Valsartan from rat plasma (Figures 1 & 2).…”
Section: Drug Profilementioning
confidence: 99%