Simultaneous Estimation of Solifenacin Succinate and Tamsulosin Hydrochloride in Combined Dosage Form by Using First Order Derivative Spectrophotometric Method

Abstract

Srinivasarao et al.: Derivative Spectrophotometric Method for Solifenacin Succinate and Tamsulosin HydrochlorideUsing first-order derivative techniques, a simple accurate and precise Ultraviolet spectrophotometric method was developed for the determination of solifenacin succinate and tamsulosin hydrochloride in combined dosage form. Every solifinacin succinate and tamsulosin hydrochloride was scanned in the wavelength region of 200-400 nm for determination of sampling wavelengths and selected sampling wavelengths were selected. Sampling wavelengths were chosen at 265 nm (zero crossing of solifinacin succinate) where the absorbance of tamsulosin hydrochloride was important and at 250 nm (zero crossing of tamsulosin hydrochloride) where the absorbance of solifinacin succinate was significant. For solifenacin succinate, linearity ranged from 10 to 100 μg/ml with a correlation coefficient of 0.998 and 2 to 10 μg/ml for the correlation coefficient of tamsulosin hydrochloride is 0.9988. The median recovery was considered to be satisfactory. For the routine study of solifenacin succinate and tamsulosin hydrochloride in combined dosage forms, the approach proposed can be applied.

High‐performance thin layer chromatographic method development and validation for simultaneous estimation of solifenacin succinate and silodosin using quality by design approach and greenness assessment

“…A comprehensive literature search was conducted to find methods for the analysis of solifenacin succinate and silodosin alone or in combination with other medications. Most of these methods, which include ultraviolet (UV)visible spectrophotometry [10][11][12][13][14][15], spectrofluorometry [15], high-performance liquid chromatography (HPLC) [16][17][18][19][20][21][22][23][24][25][26][27][28], ultra-HPLC [29], liquid chromatography with electrospray ionization mass spectrometry [30], and high-performance thin layer chromatography (HPTLC) [31][32][33]. There is currently no greenness defined analytical method for measuring solifenacin succinate and silodosin in tablet dosage form together.…”

Innovative electrochemical electrode modified with Al2O3nanoparticle decorated MWCNTs for ultra-trace determination of tamsulosin and solifenacin in human plasma and urine samples and their pharmaceutical dosage form

“…In addition, the other greatest obstacle is the simultaneous analysis of TAM/SOL in biological fluids due to their infinitesimal peak plasma concentrations (for TAM equal about 10.1 ng mL −1 following breakfast and equal about 17.1 ng mL −1 during fasting while for SOL equal 24.0 and 40.6 ng mL −1 , respectively). 12,13 The aforementioned challenges explain the drawbacks and difficulties facing the relatively few reported procedures, these include spectrofluorimetric method, 14,15 spectrophotometric method, 16,17 HPTLC 18 and RP-HPLC methods. 19,20 Furthermore, the in-depth study showed that many other defects were found in each of the aforementioned methods including the requirement for skilled operators, potential drug loss during re-extraction procedure, need for expensive solvents, and influence by the interference of endogenous substances, in addition, these methods require lengthy, and time-consuming processes for preparation and extraction of plasma sample.…”