Simultaneous evaluation of the lamina cribosa position and choroidal thickness changes following deep sclerectomy

Rebolleda, Gema; Juan, Victoria de; Muñoz‐Negrete, Francisco J.; Díez-Álvarez, L.

doi:10.1177/1120672117753702

Cited by 7 publications

(5 citation statements)

References 33 publications

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“…The increasing dissociation of GON and NAION with disease severity seen with the MRW was not observed for any other OCT parameter. However, consistent with previous reports, our data did show that the LC depth is also a distinguishing factor between NAION and GON in general [ 28 , 29 ]. There was no relationship observed between LC depth and severity of visual field damage in either group.…”

Section: Discussionsupporting

confidence: 93%

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Non-arteritic anterior ischemic and glaucomatous optic neuropathy: Implications for neuroretinal rim remodeling with disease severity

et al. 2023

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Purpose Post-acute non-arteritic ischemic optic neuropathy (NAION) and glaucomatous optic neuropathy (GON) can be difficult to differentiate clinically. Our objective was to identify optical coherence tomography (OCT) parameters to help differentiate these optic neuropathies. Methods We compared 12 eyes of 8 patients with NAION and 12 eyes of 12 patients with GON, matched for age and visual field mean deviation (MD). All patients underwent clinical assessment, automated perimetry (Humphrey Field Analyzer II; Carl Zeiss Meditec, Dublin, CA, USA), and OCT imaging (Spectralis OCT2; Heidelberg Engineering, Heidelberg, Germany) of the optic nerve head and macula. We derived the neuroretinal minimum rim width (MRW), peripapillary retinal nerve fibre layer (RNFL) thickness, central anterior lamina cribrosa depth, and macular retinal thickness. Results MRW was markedly thicker, both globally and in all sectors, in the NAION group compared to the GON group. There was no significant group difference in RFNL thickness, globally or in any sector, with the exception of the temporal sector that was thinner in the NAION group. The group difference in MRW increased with increasing visual field loss. Other differences observed included lamina cribrosa depth significantly greater in the GON group and significantly thinner central macular retinal layers in the NAION group. The ganglion cell layer was not significantly different between the groups. Conclusions The neuroretinal rim is altered in a dissimilar manner in NAION and GON and MRW is a clinically useful index for differentiating these two neuropathies. The fact that the difference in MRW between the two groups increased with disease severity suggests distinct remodelling patterns in response to differing insults with NAION and GON.

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Section: Discussionsupporting

confidence: 93%

“…our data did show that the LC depth is also a distinguishing factor between NAION and GON in general [28,29]. There was no relationship observed between LC depth and severity of visual field damage in either group.…”

Section: Plos Onecontrasting

confidence: 62%

Non-arteritic anterior ischemic and glaucomatous optic neuropathy: Implications for neuroretinal rim remodeling with disease severity

et al. 2023

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“…6,12 Interestingly, clinical evidence suggests that IOP and choroidal volume themselves may be linked. 45,46 A reduction of IOP via trabeculectomy or deep sclerectomy has been shown to cause a subsequent change in choroidal thickness. Thus, studies aimed at understanding the interaction of IOP and choroid volume and their combined influence on ONH biomechanics will be critical in the future.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Choroidal Swelling on Optic Nerve Head Deformation

Feola

Nelson

Myers

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…Furthermore, IOP-lowering treatment may induce change in the LC morphology in glaucomatous eyes. [18][19][20][21][22] Therefore, we compared LC morphology between eyes in treatment-naive NTG patients with unilateral damage in an attempt to elucidate whether LC strain is related to the pathogenesis of NTG.…”

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confidence: 99%

Intereye Comparison of Lamina Cribrosa Curvature in Normal Tension Glaucoma Patients With Unilateral Damage

Kim

Lee

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To investigate intereye differences in lamina cribrosa (LC) morphology in normal tension glaucoma (NTG) patients with unilateral damage. METHODS. A total of 152 eyes of 76 treatment-naive NTG patients with unilateral damage from the ongoing Investigating Glaucoma Progression Study were included. Optic nerve heads were scanned using enhanced-depth spectral-domain optical coherence tomography. The magnitude of the LC curve and LC position were assessed by measuring the LC curve index (LCCI) and LC depth (LCD), respectively, at seven locations spaced equidistantly across the vertical optic disc diameter. LCCI and LCD were compared between glaucomatous and fellow healthy eyes. RESULTS. Eyes with NTG had larger average LCCI and LCD than contralateral healthy eyes (for both P < 0.002). The LCCI was greater in the glaucomatous eyes at all seven locations (P < 0.001). Univariate conditional logistic regression analysis showed that higher baseline intraocular pressure (P ¼ 0.010), deeper LCD (P ¼ 0.007), and larger LCCI (P < 0.001) were significantly associated with the presence of glaucoma. In multivariate analysis, only larger LCCI was significantly associated with the presence of glaucoma (P < 0.001). CONCLUSIONS. Glaucomatous eyes have more steeply curved LC than fellow healthy eyes. This finding suggests that LC undergoes significant remodeling in NTG eyes.

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Simultaneous evaluation of the lamina cribosa position and choroidal thickness changes following deep sclerectomy

Abstract: There was a significant reversal lamina cribrosa displacement measured from Bruch's membrane opening reference despite a significant peripapillary choroidal thickening following deep sclerectomy. Both findings were significantly correlated with the change in intraocular pressure.

Cited by 7 publications

References 33 publications

Non-arteritic anterior ischemic and glaucomatous optic neuropathy: Implications for neuroretinal rim remodeling with disease severity

Non-arteritic anterior ischemic and glaucomatous optic neuropathy: Implications for neuroretinal rim remodeling with disease severity

The Impact of Choroidal Swelling on Optic Nerve Head Deformation

Intereye Comparison of Lamina Cribrosa Curvature in Normal Tension Glaucoma Patients With Unilateral Damage

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