Simultaneous Extensive Intraductal Papillary Neoplasm of the Bile Duct and Pancreas: A Very Rare Entity

Luvira, Vor; Pugkhem, Ake; Tipwaratorn, Theerawee; Chamgramol, Yaovalux; Pairojkul, Chawalit; Bhudhisawasdi, Vajarabhongsa

doi:10.1155/2016/1518707

Cited by 9 publications

(5 citation statements)

References 15 publications

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“…Most of the non‐malignant IPNBs (91.6%) we observed were intrahepatic, supporting the observation that IPNB of the proximal bile duct (i.e., intrahepatic and perihilar) progresses slowly compared with IPNBs located more distally . There was difficulty comparing tumors by location.…”

Section: Discussionsupporting

confidence: 74%

Long‐term outcome of surgical resection for intraductal papillary neoplasm of the bile duct

Luvira

Pugkhem

Bhudhisawasdi

et al. 2017

J of Gastro and Hepatol

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Section: Discussionsupporting

confidence: 74%

Long‐term outcome of surgical resection for intraductal papillary neoplasm of the bile duct

Luvira

Pugkhem

Bhudhisawasdi

et al. 2017

J of Gastro and Hepatol

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“…NLR and PLR are inflammatory markers known to be associated with invasive cancer in many tumors, especially IPMN [8, 9], which is considered the pancreatic counterpart of IPNB [10, 11] and both develop from the endoderm foregut almost at the same time. Interestingly, the lining epithelia of the bile duct and main pancreatic duct show similar morphologies and phenotypes, and both are accompanied by periductal glands.…”

Section: Discussionmentioning

confidence: 99%

Predictive utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intraductal papillary neoplasm of the bile duct

Luvira

Kamsa‐ard

Pugkhem

et al. 2019

ceh

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Aim of the studyIntraductal papillary neoplasm of the bile duct (IPNB) can present at various stages of the disease. Each stage needs different treatment. The neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) have been described as predictive markers for several tumors. There has been no investigation on the role of NLR and PLR in IPNB.Material and methodsWe retrospectively reviewed the medical records of 112 patients who underwent curative-intent hepatic resection for IPNB between January 2007 and December 2011. All clinical parameters and survival were analyzed for their association with NLR and PLR.ResultsFor prediction of malignancy, the best respective cut-off for NLR and PLR was 2.74 and 130, with area under the ROC curve being 0.662 and 0.763. For micro-papillary IPNB, both markers well predict malignancy and lymph node involvement. The respective area under the ROC curve of NLR and PLR for prediction of malignancy was 0.78 and 0.88. Both markers had an area under the ROC curve for prediction of lymph node involvement of 1.0. The median overall survival of those with PLR < 130 was 86.4 months compared with 45.0 months for those with PLR > 130 (p = 0.02).ConclusionsNLR and PLR seem likely candidates for predicting malignancy, lymph node involvement, and survival of the patients. PLR performed better than NLR for all predictions. The markers worked very well for micro-papillary IPNB; however, we recommend using these markers in conjunction with the radiologic appearance of tumors.

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“…When intrahepatic and extrahepatic bile duct tumors invaded to the hilar region often indicated an enhancement of tumor infiltration. Although the progress of bile duct and pancreatic papillary adenomas is relatively slow, the prognosis is often poor when multiple infiltrates appear (Luvira et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological findings and imaging features of intraductal papillary neoplasms in bile ducts

Zhang

Zhong

Kong

et al. 2020

PeerJ

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Background Intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) is considered an uncommon tumor, and there is limited understanding of IPMN-B. This study aimed to investigate the prognosis and influential factors of the IPMN-B from 58 cases. Methods The clinical data of 58 patients with pathologically confirmed IPMN-B admitted to our hospital from January 1, 2012 to August 2017 were collected and analyzed. The patients were followed up by outpatient or telephone until January 1, 2019. SPSS 19.0 software was applied for data analysis. Survival analysis was performed using Kaplan-Meier method and parallel Log-rank test. Prognostic factors were analyzed by univariate analysis and multiple Cox regression model. Results Among of all the patients, 26 cases were benign tumors and 32 cases were malignant tumors. The preoperative tumor markers CA242 and CEA of malignant IPNM-B patients were significantly higher than those in benign tumors (P < 0.05). Survival analysis showed that patients with malignant tumors had a worse prognosis. The median survival time of malignant IPMN-B patients was 40.6 ± 3.0 months, yet median survival time of benign IPMN-B patients was not reached (P = 0.19). The one-year survival rate and three-year survival rate of benign IPMN-B were 84% and 74% respectively. The one-year survival rate and three-year survival rate of malignant IPMN-B were 88% and 64% respectively. Univariate analysis showed that combined lymph node metastasis, surgical method, and differentiation degree could affect patients’ prognosis (P < 0.05). Multivariate analysis showed differentiation degree was an independent risk factor affecting prognosis (OR = 0.06, 95% confidence interval: 0.007∼0.486, P < 0.05). Conclusion The levels of CEA and CA242 were helpful to identify benign and malignant of IPNM-B. Moreover, radical surgical resection could prolong patients’ survival. Finally, differentiation degree was an independent risk factor affecting malignant IPNM-B prognosis.

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Simultaneous Extensive Intraductal Papillary Neoplasm of the Bile Duct and Pancreas: A Very Rare Entity

Cited by 9 publications

References 15 publications

Long‐term outcome of surgical resection for intraductal papillary neoplasm of the bile duct

Long‐term outcome of surgical resection for intraductal papillary neoplasm of the bile duct

Predictive utility of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in intraductal papillary neoplasm of the bile duct

Clinicopathological findings and imaging features of intraductal papillary neoplasms in bile ducts

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