Simultaneous high-performance liquid chromatographic assay of furosemide and propranolol HCL and its application in a pharmacokinetic study

El-Saharty, Yasser S.

doi:10.1016/s0731-7085(03)00229-2

Cited by 64 publications

(26 citation statements)

References 33 publications

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“…Although analytical methods have been reported for the quantitative estimation of the individual standard drugs (Carr et al, 1995;Xie and Zhou, 1995;Farca et al, 2003;Zuo et al, 2004;Lanchote et al, 1997;Danhof et al, 1979;El Saharty, 2003;Smith et al, 1980), to the best of our knowledge, a single validated analytical method for quantitative analysis of a mixture of five standard drugs, antipyrine, metoprolol, ketoprofen, phenol red and furosemide, has not been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

High‐performance liquid chromatography method development and validation for simultaneous determination of five model compounds, antipyrine, metoprolol, ketoprofen, furosemide and phenol red, as a tool for the standardization of rat in situ intestinal permeability studies using timed wavelength detection

Chawla

Ghosh

Sihorkar

et al. 2005

Biomedical Chromatography

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A simple, precise, accurate and rugged reversed-phase high-performance liquid chromatography (HPLC) method has been developed and validated for the simultaneous determination of five permeability model compounds, viz. antipyrine, metoprolol, ketoprofen, furosemide and phenol red. The method was intended to standardize rat in situ single-pass intestinal perfusion studies to assess the intestinal permeability of drugs in the market as well as new chemical entities. Optimum resolution was achieved by gradient elution on a Symmetry Shield C-18 analytical column with the mobile phase consisting of a mixture of aqueous potassium dihydrogen orthophosphate (pH 5.5; 0.01 m) and methanol at a flow rate of 1.5 mL/min. The retention times of antipyrine, metoprolol, ketoprofen, phenol red and furosemide were about 9, 12, 13, 16 and 17 min, respectively. Data acquisition was carried out using a photo diode array detector in the wavelength range 210-600 nm. Extraction of chromatograms was carried out by timed wavelength. Data obtained in all studies indicated that the method was suitable for the intended purpose. The validated method was found to be linear and precise in the working range. Suitability of storage under various conditions and freeze/thaw impact at cold temperature were established to ensure complete sample recovery without any stability issues. Recovery very close to the spiked amounts indicated that the method was highly accurate and suitable for use on routine basis.

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Section: Introductionmentioning

confidence: 99%

High‐performance liquid chromatography method development and validation for simultaneous determination of five model compounds, antipyrine, metoprolol, ketoprofen, furosemide and phenol red, as a tool for the standardization of rat in situ intestinal permeability studies using timed wavelength detection

Chawla

Ghosh

Sihorkar

et al. 2005

Biomedical Chromatography

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“…Its structure is shown in Fig.1. Several methods for the analytical determination of PRO in pharmaceutical formulations have been reported in the literature, by spectrophotometry (El-Didamony, 2010;Basavaiah et al, 2004;Zahálka et al, 2013), spectrofluorometry (Rekhi et al, 1995) and HPLC (Šatínský et al, 2013;Salman et al, 2010;El-Sahart, 2003;Abdel-Hamid, 2000). Carvedilol (CRV, Fig.…”

Section: Introductionmentioning

confidence: 99%

Application of Bromocresol Green and Bromothymol Blue for the Extractive Spectrophotometric Determination of Anti-hypertensive Drugs

El‐Didamony¹,

Hafeez²,

Saad³

2015

J App Pharm Sci

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Simple, selective and highly sensitive spectrophotometric methods are proposed for the rapid and accurate determination of anti-hypertensive drugs namely telmisartan (TEL), propranolol (PRO), bisoprolol (BIS) and carvedilol (CRV) in tablets and biological fluids using bromocressol green (BCG) and bromothymol blue (BTB). The developed methods involve formation of stable yellow colored dichloromethane extractable ion-pair complexes of the amino derivative of four antihypertensive drugs such as TEL, PRO, BIS and CRV with two sulphonphthalein acid dyes, namely; BCG and BTB in acidic buffer. The effect of optimum conditions via pH on the ion-pair formation, reagent concentration, time and temperature and solvent was studied. The composition of the ion-pairs was found 1: 1 by Job's method. The established methods having high sensitivity and good selectivity could be applied to the determination of the studied drugs in pharmaceutical, urine and blood serum samples with satisfactory results. The results obtained are good agreement with experimental data. The reaction mechanism was also discussed.

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“…The British [2] and Brazilian [3] Pharmacopoeias described a potentiometric and a spectrophotometric method of assay, respectively. Several other analytical methods involving colorimetry [4], spectrophotometry [5][6][7][8][9], atomic absorption spectrometry [9], spectrofluorometry [10-13], diffuse reflectance spectroscopy [14], chromatography [15,16], titrimetry [17], chemiluminescence combined with flow injection analysis (FIA) [18,19], potentiometry [20], and voltammetry [21][22][23] were reported. Most of the reported methods possess some disadvantages, such as long analysis time, sample pretreatment, and expensive instrumentation that make them unsuitable for routine analysis.…”

Section: Introductionmentioning

confidence: 99%

Conductometric determination of propranolol hydrochloride in pharmaceuticals

et al. 2011

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In this paper the conductometric titration of propranolol hydrochloride in pharmaceutical formulations using silver nitrate as titrant is proposed. The method was based on the formation of an insoluble salt (AgCl(s)) between the chloride of propranolol hydrochloride molecule and Ag(I) ions of the titrant AgNO3. The effect of the PROP-AgNO3 concentrations and the interval of time between the successive additions of the titrant on the shape of the titration curve were studied. The obtained recoveries for four samples ranged from 96.8 to 105%. The proposed method was successfully applied in the determination of propranolol hydrochloride in several pharmaceutical formulations, with results in close agreement at a 95 % confidence level with those obtained using official spectrophotometric method.

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Simultaneous high-performance liquid chromatographic assay of furosemide and propranolol HCL and its application in a pharmacokinetic study

Cited by 64 publications

References 33 publications

Application of Bromocresol Green and Bromothymol Blue for the Extractive Spectrophotometric Determination of Anti-hypertensive Drugs

Conductometric determination of propranolol hydrochloride in pharmaceuticals

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