Simultaneous Magnetic Particle Imaging and Navigation of large superparamagnetic nanoparticles in bifurcation flow experiments

Griese, Florian; Knopp, Tobias; Gruettner, Cordula; Thieben, Florian; Müller, Knut; Loges, Sonja; Ludewig, Peter

doi:10.1016/j.jmmm.2019.166206

Cited by 44 publications

(31 citation statements)

References 34 publications

(39 reference statements)

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“…Synomag are commercially available with amine-reactive surface groups for covalent coupling of a biofunctional molecule such as carboxyl-polyethylene glycol (COOH-PEG). While synomag MNPs previously proved to be highly suitable for magnetic hyperthermia [ 27 ] and magnetic particle imaging [ 28 , 29 ], they are probed herein with regard to their force and spatial manipulation capability.…”

Section: Resultsmentioning

confidence: 99%

Magnetic Nanoprobes for Spatio-Mechanical Manipulation in Single Cells

et al. 2021

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Magnetic nanoparticles (MNPs) are widely known as valuable agents for biomedical applications. Recently, MNPs were further suggested to be used for a remote and non-invasive manipulation, where their spatial redistribution or force response in a magnetic field provides a fine-tunable stimulus to a cell. Here, we investigated the properties of two different MNPs and assessed their suitability for spatio-mechanical manipulations: semisynthetic magnetoferritin nanoparticles and fully synthetic ‘nanoflower’-shaped iron oxide nanoparticles. As well as confirming their monodispersity in terms of structure, surface potential, and magnetic response, we monitored the MNP performance in a living cell environment using fluorescence microscopy and asserted their biocompatibility. We then demonstrated facilitated spatial redistribution of magnetoferritin compared to ‘nanoflower’-NPs after microinjection, and a higher magnetic force response of these NPs compared to magnetoferritin inside a cell. Our remote manipulation assays present these tailored magnetic materials as suitable agents for applications in magnetogenetics, biomedicine, or nanomaterial research.

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Section: Resultsmentioning

confidence: 99%

Magnetic Nanoprobes for Spatio-Mechanical Manipulation in Single Cells

et al. 2021

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“…Performance of Synomag ® -D in MPI has been evaluated using a magnetic particle spectrometer (MPS) and the results suggested better performance compared to Resovist ® 15 . Synomag ® -D has been used to image flow in phantoms 16 and to label erythrocytes and cancer cells 17 , 18 . However, studies evaluating performance of Synomag ® -D in vivo are lacking.…”

Section: Introductionmentioning

confidence: 99%

Long circulating tracer tailored for magnetic particle imaging

et al. 2021

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Superparamagnetic iron oxide nanoparticle (SPION) tracers possessing long blood circulation time and tailored for magnetic particle imaging (MPI) performance are crucial for the development of this emerging molecular imaging modality. Here, single-core SPION MPI tracers coated with covalently bonded polyethyelene glycol (PEG) brushes were obtained using a semi-batch thermal decomposition synthesis with controlled addition of molecular oxygen, followed by an optimized PEG-silane ligand exchange procedure. The physical and magnetic properties, MPI performance, and blood circulation time of these newly synthesized tracers were compared to those of two commercially available SPIONs that were not tailored for MPI but are used for MPI: ferucarbotran and PEG-coated Synomag ® -D. The new tailored tracer has MPI sensitivity that is ~3-times better than the commercial tracer ferucarbotran and much longer circulation half-life than both commercial tracers (t 1/2 =6.99 h for the new tracer, vs t 1/2 =0.59 h for ferucarbotran, and t 1/2 =0.62 h for PEG-coated Synomag ® -D).

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“…It should be noticed that even with the worst values that have occurred after the evaluation of the computational method the nanoparticles can be navigated into the desired branch of the carotid but not close to the desired trajectory. It should be noticed that using the present method the particles that are coated with the anticancer drug are moving close to the desired trajectory and not close to the walls of the arteries as in [45]. This is very crucial since the particles moving near the wall may be trapped [46].…”

Section: Discussionmentioning

confidence: 95%

An Optimized Method for 3D Magnetic Navigation of Nanoparticles inside Human Arteries

Karvelas

Liosis

Theodorakakos

et al. 2021

Fluids

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A computational method for optimum magnetic navigation of nanoparticles that are coated with anticancer drug inside the human vascular system is presented in this study. For this reason a 3D carotid model is employed. The present model use Computational Fluid Dynamics (CFD) and Discrete Element Method (DEM) techniques along with Covariance Matrix Adaptation (CMA) evolution strategy for the evaluation of the optimal values of the gradient magnetic field. Under the influence of the blood flow the model evaluates the effect of different values of the gradient magnetic field in order to minimize the distance of particles from a pre-described desired trajectory. Results indicate that the diameter of particles is a crucial parameter for an effective magnetic navigation. The present numerical model can navigate nanoparticles with diameter above 500 nm with an efficiency of approximately 99%. It is found that the velocity of the blood seems to play insignificant role in the navigation process. A reduction of 25% in the inlet velocity leads the particles only 3% closer to the desired trajectory. Finally, the computational method is more efficient as the diameter of the vascular system is minimized because of the weak convective flow. Under a reduction of 50% in the diameter of the carotid artery the computational method navigate the particles approximately 75% closer to the desired trajectory. The present numerical model can be used as a tool for the determination of the parameters that mostly affect the magnetic navigation method.

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Simultaneous Magnetic Particle Imaging and Navigation of large superparamagnetic nanoparticles in bifurcation flow experiments

Cited by 44 publications

References 34 publications

Magnetic Nanoprobes for Spatio-Mechanical Manipulation in Single Cells

Magnetic Nanoprobes for Spatio-Mechanical Manipulation in Single Cells

Long circulating tracer tailored for magnetic particle imaging

An Optimized Method for 3D Magnetic Navigation of Nanoparticles inside Human Arteries

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