Simultaneous measurement of 16 bisphenol A analogues in house dust and evaluation of two sampling techniques

Fan, Xinghua; Katuri, Guru Prasad; Caza, Amelia Anne; Rasmussen, Pat E.; Kubwabo, Cariton

doi:10.1016/j.emcon.2020.12.001

Cited by 27 publications

(19 citation statements)

References 46 publications

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“…Table 8 compares the validation parameters of the developed USAEME-GC/MS method with methods of BP determination in different matrices described in the literature. The comparison with other methods based on the use of the GC/MS technique shows that depending on the matrix under consideration, the quality of the proposed method is similar or even higher [ 29 , 48 , 49 , 50 ]. When we consider the same matrices, i.e., wastewater, we can see that in terms of precision, accuracy and repeatability, the developed method does not differ from the methods described in the literature [ 46 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

USAEME-GC/MS Method for Easy and Sensitive Determination of Nine Bisphenol Analogues in Water and Wastewater

et al. 2022

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A new, simple and sensitive method for isolating nine compounds from the bisphenol group (analogues: A, B, C, E, F, G, Cl2, Z, AP) based on one-step liquid–liquid microextraction with in situ acylation followed by gas chromatography-mass spectrometry was developed and validated using influent and effluent wastewaters. The chemometric approach based on the Taguchi method was used to optimize the main conditions of simultaneous extraction and derivatization. The recoveries of the proposed procedure ranged from 85 to 122%, and the repeatability expressed by the coefficient of variation did not exceed 8%. The method’s limits of detection were in the range of 0.4–64 ng/L, and the method’s limits of quantification ranged from 1.3 to 194 ng/L. The developed method was used to determine the presence of the tested compounds in wastewater from a municipal wastewater treatment plant located in northeastern Poland. From this sample, eight analytes were detected. Concentrations of bisphenol A of 400 ng/L in influent and 100 ng/L in effluent were recorded, whereas other bisphenols reached 67 and 50 ng/L for influent and effluent, respectively. The removal efficiency of bisphenol analogues in the tested wastewater treatment plant ranged from 7 to approximately 88%.

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Section: Resultsmentioning

confidence: 99%

USAEME-GC/MS Method for Easy and Sensitive Determination of Nine Bisphenol Analogues in Water and Wastewater

et al. 2022

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“…Another consideration for risk-based prioritization is that many chemicals have no known exposure levels; however, many of these chemicals could have functional properties that make them suitable substitutes for chemicals undergoing risk management. For example, several analogs to the known endocrine disruptor bisphenol A exist on the DSL, and such analogues have been detected in Canadian house dust ( Fan et al, 2021 ), highlighting the rising concern about these replacements, and similarly for others across the broad chemical space, in commerce. Moreover, many chemicals without known exposure may have broad use applications that are known, and this information could enable exposure levels to be estimated.…”

Section: Discussionmentioning

confidence: 99%

Implementing in vitro bioactivity data to modernize priority setting of chemical inventories

Beal

Gagné

Kulkarni

et al. 2021

ALTEX

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Internationally, there are thousands of existing and newly introduced chemicals in commerce, highlighting the ongoing importance of innovative approaches to identify emerging chemicals of concern. For many chemicals, there is a paucity of hazard and exposure data. Thus, there is a crucial need for efficient and robust approaches to address data gaps and support risk-based prioritization. Several studies have demonstrated the utility of in vitro bioactivity data from the ToxCast program in deriving points of departure (PODs). ToxCast contains data for nearly 1,400 endpoints per chemical, and the bioactivity concentrations, indicative of potential adverse outcomes, can be converted to human-equivalent PODs using high-throughput toxicokinetics (HTTK) modeling. However, data gaps need to be addressed for broader application: the limited chemical space of HTTK and quantitative high-throughput screening data. Here we explore the applicability of in silico models to address these data needs. Specifically, we used ADMET predictor for HTTK predictions and a generalized read-across approach to predict ToxCast bioactivity potency. We applied these models to profile 5,801 chemicals on Canada’s Domestic Substances List (DSL). To evaluate the approach’s performance, bioactivity PODs were compared with in vivo results from the EPA Toxicity Values database for 1,042 DSL chemicals. Comparisons demonstrated that the bioactivity PODs, based on ToxCast data or read-across, were conservative for 95% of the chemicals. Comparing bioactivity PODs to human exposure estimates supports the identification of chemicals of potential interest for further work. The bioactivity workflow shows promise as a powerful screening tool to support effective triaging of chemical inventories.

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“…Data summaries for all of the substances included in this paper are provided in the Supplementary Information (SI-6 to SI-16) , and details of the analytical methods were published previously. Analytical approaches were developed or optimized, in Health Canada laboratories, to provide quantitative determinations of the synthetic organic compounds [ 43 , 44 , 45 , 46 , 48 , 49 , 50 , 51 , 52 , 54 ]. Total element concentrations were determined using Inductively Coupled Plasma Mass Spectrometry (ICP–MS), Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES), Instrumental Neutron Activation Analysis (INAA), or (in the case of mercury) direct solid sample analysis using atomic absorption spectrometry [ 17 , 22 , 47 , 55 ].…”

Section: Methodsmentioning

confidence: 99%

“…Composite (whole-house) vacuum dust samples were collected from 13 cities during the winter season of 2007 to 2010 (incl.) and analysed quantitatively for organic and inorganic contaminants [ 17 , 22 , 39 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ]. This study uses Spearman rank analysis to identify relationships between house characteristics and 59 elements (metals and metalloids), and >200 synthetic organics, including phthalates; bisphenol A (BPA) and BPA analogues; organophosphate esters (OPEs); halogenated flame retardants including polybrominated diphenyl ethers (BDEs); octylphenol and nonylphenol ethoxylates; aryl and alkyl-aryl phosphates; bactericides (parabens); pesticides (e.g., permethrin, organochlorines); and synthetic musks.…”

Section: Introductionmentioning

confidence: 99%

Relationships between House Characteristics and Exposures to Metal(loid)s and Synthetic Organic Contaminants Evaluated Using Settled Indoor Dust

Rasmussen

Kubwabo

Gardner

et al. 2022

IJERPH

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This study investigates associations between house characteristics and chemical contaminants in house dust, collected under the nationally representative Canadian House Dust Study (2007–2010). Vacuum samples (<80 µm fraction) were analysed for over 200 synthetic organic compounds and metal(loid)s. Spearman rank correlations between contaminant concentrations in dust and presence of children and pets, types of flooring, heating styles and other characteristics suggested a number of indoor sources, pointing to future research directions. Numerous synthetic organics were significantly associated with reported use of room deodorizers and with the presence of cats in the home. Hardwood flooring, which is a manufactured wood product, emerged as a source of metal(loid)s, phthalates, organophosphate flame retardants/plasticizers, and obsolete organochlorine pesticides such as ∑DDT (but not halogenated flame retardants). Many metal(loid)s were significantly correlated with flame-retardant compounds used in building materials and heating systems. Components of heating appliances and heat distribution systems appeared to contribute heat-resistant chemicals and alloys to settled dust. Carpets displayed a dual role as both a source and repository of dust-borne contaminants. Contaminant loadings (<80 µm fraction) were significantly elevated in heavily carpeted homes, particularly those located near industry. Depending on the chemical (and its source), the results show that increased dust mass loading may enrich or dilute chemical concentrations in dust. Research is needed to improve the characterisation of hidden indoor sources such as flame retardants used in building materials and heating systems, or undisclosed ingredients used in common household products, such as air fresheners and products used for companion animals.

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Simultaneous measurement of 16 bisphenol A analogues in house dust and evaluation of two sampling techniques

Cited by 27 publications

References 46 publications

USAEME-GC/MS Method for Easy and Sensitive Determination of Nine Bisphenol Analogues in Water and Wastewater

USAEME-GC/MS Method for Easy and Sensitive Determination of Nine Bisphenol Analogues in Water and Wastewater

Implementing in vitro bioactivity data to modernize priority setting of chemical inventories

Relationships between House Characteristics and Exposures to Metal(loid)s and Synthetic Organic Contaminants Evaluated Using Settled Indoor Dust

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