Simultaneous mechanical property and biodegradation improvement of wollastonite bioceramic through magnesium dilute doping

Xie, Jiajun; Yang, Xianyan; Shao, Huifeng; Ye, Juan; He, Yong; Fu, Jianzhong; Gao, Changyou; Gou, Zhongru

doi:10.1016/j.jmbbm.2015.09.012

Cited by 83 publications

(70 citation statements)

References 49 publications

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“…Also, it restores cell proliferation and adhesion of osteoblast cells, but the slow rate of apatite deposition restricts its application towards hard tissue engineering . The optimum level of Mg ion concentration is necessary for the benefit of vascularisation . It was also found that the increase of forsterite content in bioglass/forsterite composites increases its mechanical strength .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Bioactivity and Mechanical Stability of Mg/Ca Silicate Biocomposites Developed for Tissue Engineering Applications

Venkatraman

Swamiappan

2019

ChemistrySelect

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Bioceramics used in hard tissue engineering applications should primarily meet the criteria of mechanical strength and apatite mineralisation of natural bone. In such a scenario, designing of bioceramic composites is inevitable as calcium silicates possess good apatite deposition ability and magnesium silicates show excellent mechanical stability. The present study investigates the influence of calcium (Ca) and magnesium (Mg) ions of the bioceramics on bioactivity and mechanical strength. Binary silicates such as wollastonite (CaSiO3), enstatite (MgSiO3) and forsterite (Mg2SiO4) were prepared by sol‐gel combustion technique. Functional group identification and phase formation of the silicate materials were analysed by FT‐IR and X‐ray diffraction studies respectively. Furthermore, apatite mineralisation ability and mechanical strength of wollastonite were evaluated. Influence of wollastonite on the bioactivity of both enstatite and forsterite was also investigated. The obtained results conferred that the wollastonite possesses good apatite formation ability, moderate resorbability and low mechanical strength. The composites of wollastonite show improvement in the enstatite with respect to bioactivity and in forsterite with respect to superior mechanical properties.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Bioactivity and Mechanical Stability of Mg/Ca Silicate Biocomposites Developed for Tissue Engineering Applications

Venkatraman

Swamiappan

2019

ChemistrySelect

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“…Wollastonite (CaSiO 3 ; CSi) is a promising bone implants due to its good osteoconductivity and bioresorbability, which has been either studied as alloy coating, granules or a sintered porous body with defined shape [9,10]. Most recently, we found that the CSi ceramic can be rationally tuned in phase ( or β), mechanical strength (in compression and bending mode), and fracture toughness (>3.2 MPa·m 1/2 ) through the usage of Mg doping at precisely defined dilute contents [11]. The optimal mechanical parameters, which match well with the load-bearing bone conditions, can be obtained when 6−10 mol% Ca is substituted by Mg in CSi.…”

Section: Introductionmentioning

confidence: 99%

“…In the present study, a detailed investigation of the composition-structure-strength relationship during one-or two-step sintering has been performed to explore the main function refinement in extrusion-based 3D printing porous bioceramics. 4 The CSi-Mg powder containing ~2.12 wt% Mg (10 mol% Ca was substituted by Mg in wollastonite) were synthesized by a conventional wet-chemical co-precipitation method [11]. The as-calcined CSi-Mg powders were ground using zirconia ball media in ethanol for 4 h. The particle size of the resulting powders was below 2 μm.…”

Section: Introductionmentioning

confidence: 99%

3D printing magnesium-doped wollastonite/β-TCP bioceramics scaffolds with high strength and adjustable degradation

Shao

et al. 2016

Journal of the European Ceramic Society

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Mechanical strength of bioceramic scaffolds is a problem to treat the load bearing bone defects. We developed the Mg-doping wollastonite (CSi-Mg)-based scaffolds with high strength via 3D printing technology. The effect of pore size, β-tricalcium phosphate (β-TCP) content (x%), and heating schedule on the strength of scaffolds were investigated systematically. Incorporation of β-TCP could readily adjust the sintering properties of the CSi-Mg scaffolds and the scaffolds with high (20~30%) and low (10~20%) β-TCP possess much high strength (80~100 MPa or 120~140 MPa) after undergoing one-or two-step sintering. Meanwhile, the CSi-Mg/TCPx (x=10, 20) with medium-pore (~320 µm) had over 100 MPa in compression and ~52% in porosity. In particular, the composite scaffolds maintained appreciable strength (over 50 MPa) after immersion in Tris buffer for a long time stage (6 weeks). These findings demonstrate that the CSi-Mg/TCPx scaffolds are promising for treating some challengeable bone defects, especially for load-bearing bone repair.

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“…The incorporation of bioactive ceramic materials is expected to stimulate the osseointegration of the scaffolds due to the osteoconduction achieved by bone cell growth [ 1 , 11 ]. A wide range of bioactive ceramics, such as calcium phosphates, bioactive glass and calcium silicates, with similarities in composition to the inorganic phase of bone tissue were used to fabricate composite scaffolds for bone tissue engineering [ 1 , 4 , 5 , 22 , 23 ]. The main combination of biomaterials for composite scaffolds fabrication as bone tissue mimics was based on calcium phosphates as an inorganic component and hydrogels precursors as organic phase [ 3 , 12 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Development of 3D Bioactive Scaffolds through 3D Printing Using Wollastonite–Gelatin Inks

et al. 2020

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The bioactivity of scaffolds represents a key property to facilitate the bone repair after orthopedic trauma. This study reports the development of biomimetic paste-type inks based on wollastonite (CS) and fish gelatin (FG) in a mass ratio similar to natural bone, as an appealing strategy to promote the mineralization during scaffold incubation in simulated body fluid (SBF). High-resolution 3D scaffolds were fabricated through 3D printing, and the homogeneous distribution of CS in the protein matrix was revealed by scanning electron microscopy/energy-dispersive X-ray diffraction analysis (SEM/EDX) micrographs. The bioactivity of the scaffold was suggested by an outstanding mineralization capacity revealed by the apatite layers deposited on the scaffold surface after immersion in SBF. The biocompatibility was demonstrated by cell proliferation established by MTT assay and fluorescence microscopy images and confirmed by SEM micrographs illustrating cell spreading. This work highlights the potential of the bicomponent inks to fabricate 3D bioactive scaffolds and predicts the osteogenic properties for bone regeneration applications.

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Simultaneous mechanical property and biodegradation improvement of wollastonite bioceramic through magnesium dilute doping

Cited by 83 publications

References 49 publications

Synthesis, Bioactivity and Mechanical Stability of Mg/Ca Silicate Biocomposites Developed for Tissue Engineering Applications

Synthesis, Bioactivity and Mechanical Stability of Mg/Ca Silicate Biocomposites Developed for Tissue Engineering Applications

3D printing magnesium-doped wollastonite/β-TCP bioceramics scaffolds with high strength and adjustable degradation

Development of 3D Bioactive Scaffolds through 3D Printing Using Wollastonite–Gelatin Inks

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