Simultaneous mixed phenotype and neuroimaging of progressive supranuclear palsy, progressive ataxia and palatal tremor: two different faces of tauopathies

Abstract

Images In neurologyVideo. Patient with mixed phenotype: progressive supranuclear palsy, progressive ataxia and palatal tremor. Note gait instability, ataxia, bradykinesia, tremor, vertical gaze palsy and palatal tremor.

Four New Cases of Progressive Ataxia and Palatal Tremor (PAPT) and a Literature Review

“…With the lack of other seminal findings on extensive aetiological work-up, the relatively isolated clinical PAPT syndrome, the disease course, and the cerebral imaging in this patient would be consistent with case reports of patients with presumed idiopathic PAPT [6,[9][10][11][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39].…”

“…Moreover, in an extensive review of HOD aetiologies, the study did not find any patients with MSA as the underlying cause [69]. However, the fact that PT was described in patients with progressive supranuclear palsy (PSP) [39,70] would be in keeping with the presumed tau pathology of idiopathic PAPT syndromes [9][10][11].…”