Simultaneous multi-element and multi-isotope detection in single-particle ICP-MS analysis: Principles and applications

Tian, Xiangwei; Jiang, Haowen; Hu, Ligang; Wang, Meng; Cui, Wenbin; Shi, Jianbo; Liu, Guangliang; Yin, Yongguang; Cai, Yong; Jiang, Guibin

doi:10.1016/j.trac.2022.116746

Cited by 28 publications

(25 citation statements)

References 87 publications

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“…SP-ICP-MS technique enables rapid measurements of size, mass, concentration, and element/isotope concentration. However, the monitoring of multiple elements in an individual NP in a single run is not possible [4,72,78]. Although the increase in acquisition time and peak-jumping enables for multi-element analysis of single particle to some extent, it was observed that the multiple detection is still limited to at most two targeted elements in each NP [69].…”

Section: Determination Of the Elemental And Isotopic Composition Of Npsmentioning

confidence: 99%

“…Due to the unique physicochemical properties compared with bulk materials, nanomaterials have found applications in various fields including biomedical and environmental applications [1][2][3]. Materials in nanosized scale can occur in the environment and human life not only as a results of bioformation but also can be produced unintentionally during natural process or intentionally for specific applications [4]. According to the European Commission recommendation, a nanomaterial is a natural, incidental, or manufactured material containing particles in an unbound, aggregate, or agglomerate form, where more than half or more of the particles present in particle population have one or more external dimensions ranging from 1 to 100 nm [5,6].…”

Section: Introductionmentioning

confidence: 99%

“…In the recent years, several reviews concerning the application of analytical methodologies for nanoobjects have been published. These papers mainly focused on the use of mass spectrometry techniques for detection and quantification of NPs in different types of samples [1,4,7,16,17,19,30,31]. The main aim of this paper is to critically review the spectrometric approaches for NP characterization studies.…”

Section: Introductionmentioning

confidence: 99%

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Basic and advanced spectrometric methods for complete nanoparticles characterization in bio/eco systems: current status and future prospects

Borowska

Jankowski

2023

Anal Bioanal Chem

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The use of engineered nanoparticles in the environment and human life has increased in the last 20 years. The risk assessment concerning application of nanomaterials in biological systems requires their thorough characterization. Understanding the correlations between physicochemical properties of nanoparticles concerning not only the size, particle size distribution, number concentration, degree of aggregation, or agglomeration but also solubility, stability, binding affinity, surface activity, chemical composition, and nanoparticle synthesis yield allows their reliable characterization. Thus, to find the structure-function/property relationship of nanoparticles, multifaceted characterization approach based on more than one analytical technique is required. On the other hand, the increasing demand for identification and characterization of nanomaterials has contributed to the continuous development of spectrometric techniques which enables for their qualitative and quantitative analysis in complex matrices giving reproducible and reliable results. This review is aimed at providing a discussion concerning four main aspects of nanoparticle characterization: nanoparticle synthesis yield, particle size and number concentration, elemental and isotopic composition of nanoparticles, and their surface properties. The conventional and non-conventional spectrometric techniques such as spectrophotometry UV-Vis, mass spectrometric techniques working in conventional and single-particle mode, or those based on optical emission detection systems are described with special emphasis paid on their advantages and drawbacks. The application and recent advances of these methods are also comprehensively reviewed and critically discussed. Graphical abstract

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Section: Determination Of the Elemental And Isotopic Composition Of Npsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Basic and advanced spectrometric methods for complete nanoparticles characterization in bio/eco systems: current status and future prospects

Borowska

Jankowski

2023

Anal Bioanal Chem

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“…With proper calibration, the mass(es) of element(s) in an individual particle can be determined and the diameter of the particle can be estimated assuming particle density, stoichiometry, and shape. − By counting particle events per time and determining the volumetric flux (mL/s) of sample into the plasma, spICP-MS can also be used to determine particle number concentrations (PNCs) . To date, spICP-MS has been used for a range of sample types, − including the analysis of well-characterized metal NPs, engineered particles released from consumer products, natural NPs in surface waters, atmospheric mineral dust aerosols, NPs and microparticles from ice cores, and single cells …”

Section: Introductionmentioning

confidence: 99%

Mass-Dependent Critical Value Expressions for Particle Finding in Single-Particle ICP-TOFMS

Gundlach‐Graham

Lancaster

2023

Anal. Chem.

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In time-of-flight mass spectrometry (TOFMS), ion detection is often achieved via electron multiplication followed by fast analog-to-digital conversion (ADC). This detection approach is chosen over time-to-digital conversion because it extends the dynamic range of TOFMS measurements, especially for transient analyses. However, fast ADC detection also introduces measurement noise fundamental to the electron multiplication process. In previous research, we demonstrated that TOFMS signals acquired with fast ADC follow a compound Poisson distribution in which the Poisson-distributed arrival of ions at the detector is compounded with the response profile of the electron multiplier. Here, we consider the influence of mass-to-charge (m/z)-dependent detector responses and their impact on particle-finding accuracy in single-particle inductively coupled plasma TOFMS (spICP-TOFMS). In spICP-TOFMS, highly time-resolved ion signals are recorded and particle signals are distinguished from background signals based on thresholding the data at m/z-specific critical values. Through Monte Carlo modeling with measured m/z-dependent detector responses, we generate compound Poisson model distributions and critical values that accurately account for the dispersion of measured signals. We test the accuracy of critical values through the analysis of dissolved element solutions and comparison of measured versus predicted event rates above critical value thresholds. The use of m/z-dependent compound Poisson critical values reduces false-positive particle identifications by one to two orders of magnitude compared to thresholding criteria based on normal or Poisson statistics. The improved accuracy and robustness of compound Poisson critical values enables automated multi-element particle finding in spICP-TOFMS.

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“…16,17 Recent reports have provided figures of merit of the various ICP-TOFMS instruments available. 21,24,25 Three instrumentation companies-TOFWERK, Nu Instruments, and Standard BioTools (formerly Fluidigm)-currently make ICP-TOFMS instruments with sufficient time resolution for single-particle analysis. 21,26,27 Of these instruments, those from TOFWERK (icpTOF® series) and Nu Instruments (Vitesse®) provide complete elemental mass range measurements.…”

Section: Introductionmentioning

confidence: 99%

Characterization of a high-sensitivity ICP-TOFMS instrument for microdroplet, nanoparticle, and microplastic analyses

Harycki

Gundlach‐Graham

2023

J. Anal. At. Spectrom.

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Simultaneous multi-element and multi-isotope detection in single-particle ICP-MS analysis: Principles and applications

Cited by 28 publications

References 87 publications

Basic and advanced spectrometric methods for complete nanoparticles characterization in bio/eco systems: current status and future prospects

Basic and advanced spectrometric methods for complete nanoparticles characterization in bio/eco systems: current status and future prospects

Mass-Dependent Critical Value Expressions for Particle Finding in Single-Particle ICP-TOFMS

Characterization of a high-sensitivity ICP-TOFMS instrument for microdroplet, nanoparticle, and microplastic analyses

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