Simultaneous occurrence of MRSA and ESBL-producing Enterobacteriaceae on pig farms and in nasal and stool samples from farmers

Fischer, Julia; Hille, Katja; Ruddat, Inga; Mellmann, Alexander; Köck, Robin; Kreienbrock, Lothar

doi:10.1016/j.vetmic.2016.05.021

Cited by 56 publications

(52 citation statements)

References 30 publications

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“…Many studies have reported the presence of ST10 and ST38 in both humans and animals, suggesting that E. coli isolates belonging to these STs are transmissible between animals and humans and could adapt to the intestinal tracts of either species (5,34). In contrast, ST117 has been commonly identified among animals such as cattle and is relatively rare in pigs (35,36). Our findings that ST117 was the predominant ST in ESBL producers isolated from pigs and showed multiple resistance profiles are unique.…”

Section: Discussionmentioning

confidence: 58%

Detection of <i>Escherichia coli</i> Producing CTX-M-1-Group Extended-Spectrum β-Lactamases from Pigs in Aichi Prefecture, Japan, between 2015 and 2016

et al. 2018

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Section: Discussionmentioning

confidence: 58%

Detection of <i>Escherichia coli</i> Producing CTX-M-1-Group Extended-Spectrum β-Lactamases from Pigs in Aichi Prefecture, Japan, between 2015 and 2016

et al. 2018

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“…Recently, the same approach has been used to study the clonality of ESBL-producing Enterobacteriaceae from environmental and stool samples from farmers suggesting possible cross-transmission between the farmers and the environment. This was only based on number of allele differences (Fischer et al, 2016) which makes it difficult to interpret results without considering the total number of genes included in the cgMLST scheme. In our study, we determined the genetic relatedness between ESBL- E. coli using cgMLST or wgMLST comparison and genetic distance calculation.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Extended-Spectrum β-Lactamase-Producing E. coli and Vancomycin-Resistant Enterococci in the Northern Dutch–German Cross-Border Region

et al. 2017

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Objectives: To reveal the prevalence and epidemiology of extended-spectrum β-lactamase (ESBL)- and/or plasmid AmpC (pAmpC)- and carbapenemase (CP) producing Enterobacteriaceae and vancomycin-resistant enterococci (VRE) across the Northern Dutch–German border region.Methods: A point-prevalence study on ESBL/pAmpC/CP producing Enterobacteriaceae and VRE was carried out in hospitalized patients in the Northern Netherlands (n = 445, 2012–2013) and Germany (n = 242, 2012). Healthy individuals from the Dutch community (n = 400, 2010–2012) were also screened. In addition, a genome-wide gene-by-gene approach was applied to study the epidemiology of ESBL-Escherichia coli and VRE.Results: A total of 34 isolates from 27 patients (6.1%) admitted to Dutch hospitals were ESBL/pAmpC positive and 29 ESBL-E. coli, three pAmpC-E. coli, one ESBL-Enterobacter cloacae, and one pAmpC-Proteus mirabilis were found. In the German hospital, 18 isolates (16 E. coli and 2 Klebsiella pneumoniae) from 17 patients (7.7%) were ESBL positive. In isolates from the hospitalized patients CTX-M-15 was the most frequently detected ESBL-gene. In the Dutch community, 11 individuals (2.75%) were ESBL/pAmpC positive: 10 ESBL-E. coli (CTX-M-1 being the most prevalent gene) and one pAmpC E. coli. Six Dutch (1.3%) and four German (3.9%) hospitalized patients were colonized with VRE. Genetic relatedness by core genome multi-locus sequence typing (cgMLST) was found between two ESBL-E. coli isolates from Dutch and German cross-border hospitals and between VRE isolates from different hospitals within the same region.Conclusion: The prevalence of ESBL/pAmpC-Enterobacteriaceae was similar in hospitalized patients across the Dutch–German border region, whereas VRE prevalence was slightly higher on the German side. The overall prevalence of the studied pathogens was lower in the community than in hospitals in the Northern Netherlands. Cross-border transmission of ESBL-E. coli and VRE seems unlikely based on cgMLST analysis, however continuous monitoring is necessary to control their spread and stay informed about their epidemiology.

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“…Among them, STEC strains, especially serotype O157, are most prevalent in healthy pigs (Table ). In addition, a high number of Extended‐Spectrum Beta‐Lactamase (ESBL) bacteria that are resistant to beta‐lactam antimicrobials have been recovered from pig farms (45–79% of tested farms) (Hammerum et al., ; Dohmen et al., ; Fischer et al., ). Therefore, pigs are now regarded as potential ‘producers’ of ESBL‐bacteria, especially ESBL‐ E. coli .…”

Section: Salmonella Enterica and Escherichia Coli Prevalence In Pigs mentioning

confidence: 99%

Review on the effects of potential prebiotics on controlling intestinal enteropathogens Salmonella and Escherichia coli in pig production

Tran

Everaert

Bindelle

2016

Animal Physiology Nutrition

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Summary Salmonella enterica serotypes (Salmonella sp.) are the second cause of bacterial foodborne zoonoses in humans after campylobacteriosis. Pork is the third most important cause for outbreak‐associated salmonellosis, and colibacillosis is the most important disease in piglets and swine. Attachment to host cells, translocation of effector proteins into host cells, invasion and replication in tissues are the vital virulence steps of these pathogens that help them to thrive in the intestinal environment and invade tissues. Feed contamination is an important source for Salmonella infection in pig production. Many on‐farm feeding strategies intervene to avoid the introduction of pathogens onto the farm by contaminated feeds or to reduce infection pressure when pathogens are present. Among the latter, prebiotics could be effective at protecting against these enteric bacterial pathogens. Nowadays, a wide range of molecules can potentially serve as prebiotics. Here, we summarize the prevalence of Salmonella sp. and Escherichia coli in pigs, understanding of the mechanisms by which pathogens can cause disease, the feed related to pathogen contamination in pigs and detail the mechanisms on which prebiotics are likely to act in order to fulfil their protective action against these pathogens in pig production. Many different mechanisms involve the inhibition of Salmonella and E. coli by prebiotics such as coating the host surface, modulation of intestinal ecology, downregulating the expression of adhesin factors or virulence genes, reinforcing the host immune system.

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Simultaneous occurrence of MRSA and ESBL-producing Enterobacteriaceae on pig farms and in nasal and stool samples from farmers

Cited by 56 publications

References 30 publications

Detection of <i>Escherichia coli</i> Producing CTX-M-1-Group Extended-Spectrum β-Lactamases from Pigs in Aichi Prefecture, Japan, between 2015 and 2016

Detection of <i>Escherichia coli</i> Producing CTX-M-1-Group Extended-Spectrum β-Lactamases from Pigs in Aichi Prefecture, Japan, between 2015 and 2016

Epidemiology of Extended-Spectrum β-Lactamase-Producing E. coli and Vancomycin-Resistant Enterococci in the Northern Dutch–German Cross-Border Region

Review on the effects of potential prebiotics on controlling intestinal enteropathogens Salmonella and Escherichia coli in pig production

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