Simultaneous polarographic determination of isoniazid and rifampicin by differential pulse polarography method and support vector regression

Asadpour‐Zeynali, Karim; Soheili-Azad, Payam

doi:10.1016/j.electacta.2010.06.018

Cited by 28 publications

(11 citation statements)

References 28 publications

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“…Among these methods, electrochemical methods offer advantages including high sensitivity, simplicity and reproducibility [15,[21][22][23][24][25][26][27]. Various types of electrodes have been developed to determine INZ, including overoxidized polypyrrole glassy carbon modified electrode [28], poly(sulfosalicylic acid)/electroreduced carboxylated graphene modified glassy carbon electrode [19], carbon nanotube modified electrode [25], bentonite clay modified electrodes [21], poly(amidosulfonic acid) modified glassy carbon electrode [27], rhodium modified glassy carbon electrode [15], ordered mesoporous carbon modified GCE [26], poly(L-histidine) modified screen-printed carbon electrode [22], gold electrode [29], dropping mercury electrode [30], electrochemically reduced graphene oxide modified GCE [16] and thionine immobilized multiwalled carbon nanotube modified carbon paste electrode [31]. But, in most papers, the oxidation of INZ at modified electrodes required a high over-potential, acidic or alkaline supporting electrolyte, which brought great inconvenience to the analytical procedure and unsuitable for the detection [26].…”

Section: Introductionmentioning

confidence: 99%

Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide–Au nanomaterials

Guo

Wang

et al. 2015

Materials Science and Engineering: C

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Section: Introductionmentioning

confidence: 99%

Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide–Au nanomaterials

Guo

Wang

et al. 2015

Materials Science and Engineering: C

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“…Hence, the development of rapid and accurate analytical methods is important for the determination of INZ in the pharmaceutical formulation and human serum. Several methods are available for the determination of INZ such as spectrophotometry [30], fluorimetry [31], chromatography [32], capillary electrophoresis [33], and the electro-analytical methods [34][35][36]. The electro-analytical techniques are more interesting due to their good sensitivity, accuracy, simplicity, and rapidity.…”

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confidence: 99%

Electrochemical synthesis of Fe/Al-layered double hydroxide on a glassy carbon electrode: application for electrocatalytic reduction of isoniazid

2015

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IntroductionAnionic clays or layered double hydroxide (LDH) materials are positively charged nano-structures. The chemical and physical properties of LDHs are very close to hydrotalcite, [Mg 6 Al 2 (OH) 16 ]CO 3 .4H 2 O, due to their structural similarities [1]. The structure of layered double hydroxides (LDHs) is based upon the structure of brucite, and the partial substitution of the divalent cations for the trivalent ones in their network that makes brucite positively charged. The positive charges appeared in the layers are neutralized by the anions existing between the layers. The general chemical formula for LDHs can be expressed as [M II 1−x M III x (OH) 2 ] x+ [A n− x/n · mH 2 O] x− , where M II represents a divalent metal such as Mg, Co, Ni, Cu, Zn, and Ca, M III is a trivalent metal such as Al, Cr, Fe, and Ga, and A n− is an anion. x is equal to the M III /(M II + M III )ratio. The value for x has been reported to be in the range of 0.2-0.33 in the formation of a pure LDH phase. The anions and water molecules intercalated into the LDH interlayers can be replaced with other organic and inorganic anions [2][3][4]. Due to their suitable properties such as large specific surface area, good chemical and thermal stability, high anion exchange capacity, adsorption property, and catalytic activity, LDHs have many applications in different fields such as catalysis [5,6], photochemistry [7, 8], polymer additives [9], supercapacitors [10], anti-corrosion coatings [11], pharmaceuticals [12, 13], separation technology [14-16], electrode surface modification, and sensors [17, 18]. Different methods have been introduced for the synthesis of LDHs such as the thermal or hydrothermal co-precipitation [19, 20], area hydrolysis [21], and the ion exchange method [22]. In addition to the aforementioned methods, novel methods including the sol-gel [23] and electrochemical [24, 25] ones have been reported for the synthesis of Abstract Fe/Al-layered double hydroxide (Fe/Al-LDH)was synthesized on a glassy carbon electrode (GCE) by a novel and simple electrochemical method. The electrochemical characterization of Fe/Al-LDH deposited on GCE was investigated in a 0.1 M NaOH solution. Moreover, the LDH film obtained was characterized by X-ray diffraction (XRD), Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), and energy dispersive X-ray (EDX). The obtained results showed that Fe/ Al-LDH was generated on GCE by the electrochemical method, and that the obtained film was highly pure. The electrochemical behavior of isonicotinic acid hydrazide or isoniazid (INZ) at LDH/GCE was studied by the electrochemical techniques including cyclic voltammetry, differential pulse voltammetry, and amperometry. The obtained results indicated an excellent electrocatalytic reduction activity for the Fe/Al-LDH-modified GCE of INZ. Under the optimized conditions for determination of INZ the calibration curves are linear in the ranges of 4.9-650.0 and 4.9-770.0 μM with limit of detections of 4.0 and 7.0 μM for differential...

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“…Another parameter is which is related to noise in the data. A common type of kernel function is a radial basis function (RBF) [34][35][36][37]. This function has a parameter ( ) which should be optimized and controls the generalization ability of the SVM.…”

Section: Svmmentioning

confidence: 99%

Quantitative Structure-activity Relationships of Imidazole-containing Farnesyltransferase Inhibitors Using Different Chemometric Methods

Shayanfar¹,

Ghasemi²,

Soltani³

et al. 2013

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Farnesyltranseferase inhibitors (FTIs) are one of the most promising classes of anticancer agents, but though some compounds in this category are in clinical trials there are no marketed drugs in this class yet. Quantitative structure activity relationship (QSAR) models can be used for predicting the activity of FTI candidates in early stages of drug discovery. In this study 192 imidazole-containing FTIs were obtained from the literature, structures of the molecules were optimized using Hyperchem software, and molecular descriptors were calculated using Dragon software. The most suitable descriptors were selected using genetic algorithms-partial least squares (GA-PLS) and stepwise regression, and indicated that the volume, shape and polarity of the FTIs are important for their activities. 2D-QSAR models were prepared using both linear methods, i.e., multiple linear regression (MLR), and non-linear methods, i.e., artificial neural networks (ANN) and support vector machines (SVM). The proposed QSAR models were validated using internal and external validation methods. The results show that the proposed 2D-QSAR models are valid and that they can be applied to predict the activities of imidazole-containing FTIs. The prediction capability of the 2D-QSAR (linear and non-linear) models is comparable to and somewhat better than that of previous 3D-QSAR models and the non-linear models are more accurate than the linear models.

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Simultaneous polarographic determination of isoniazid and rifampicin by differential pulse polarography method and support vector regression

Cited by 28 publications

References 28 publications

Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide–Au nanomaterials

Electrochemical sensor for Isoniazid based on the glassy carbon electrode modified with reduced graphene oxide–Au nanomaterials

Electrochemical synthesis of Fe/Al-layered double hydroxide on a glassy carbon electrode: application for electrocatalytic reduction of isoniazid

Quantitative Structure-activity Relationships of Imidazole-containing Farnesyltransferase Inhibitors Using Different Chemometric Methods

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