1999
DOI: 10.1002/(sici)1522-2594(199903)41:3<469::aid-mrm7>3.3.co;2-0
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Simultaneous recording of evoked potentials and T2‐weighted MR images during somatosensory stimulation of rat

Abstract: Somatosensory evoked potentials (SEP) and T* 2-weighted nuclear magnetic resonance (NMR) images were recorded simultaneously during somatosensory stimulation of rat to investigate the relationship between electrical activation of the brain tissue and the signal intensity change in functional NMR imaging. Electrical forepaw stimulation was performed in Wistar rats anesthetized with ␣-chloralose. SEPs were recorded with calomel electrodes at stimulation frequencies of 1.5, 3, 4.5, and 6 Hz. At the same time, T* … Show more

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Cited by 39 publications
(57 citation statements)
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“…Thus, fMRI is an indirect method for assessing neuronal activity. Therefore, it is essential to elucidate the relationship between BOLD signals and neuronal activity for interpreting the fMRI signals; this relationship has been investigated mainly by animal studies measuring evoked potentials as indices of the neuronal activity in the somatosensory cortex (Brinker et al, 1999;Van Camp et al, 2006;Goloshevsky et al, 2007;Huttunen et al, 2008;Sanganahalli et al, 2009). Although most of the human fMRI studies employ the event-related task design that has a short stimulus duration, animal studies generally investigate the relationship between BOLD signals and evoked potentials with a stimulus duration of several tens of seconds (Brinker et al, 1999;Van Camp et al, 2006;Goloshevsky et al, 2007;Huttunen et al, 2008;Sanganahalli et al, 2009).…”
Section: Introductionmentioning
confidence: 99%
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“…Thus, fMRI is an indirect method for assessing neuronal activity. Therefore, it is essential to elucidate the relationship between BOLD signals and neuronal activity for interpreting the fMRI signals; this relationship has been investigated mainly by animal studies measuring evoked potentials as indices of the neuronal activity in the somatosensory cortex (Brinker et al, 1999;Van Camp et al, 2006;Goloshevsky et al, 2007;Huttunen et al, 2008;Sanganahalli et al, 2009). Although most of the human fMRI studies employ the event-related task design that has a short stimulus duration, animal studies generally investigate the relationship between BOLD signals and evoked potentials with a stimulus duration of several tens of seconds (Brinker et al, 1999;Van Camp et al, 2006;Goloshevsky et al, 2007;Huttunen et al, 2008;Sanganahalli et al, 2009).…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, it is essential to elucidate the relationship between BOLD signals and neuronal activity for interpreting the fMRI signals; this relationship has been investigated mainly by animal studies measuring evoked potentials as indices of the neuronal activity in the somatosensory cortex (Brinker et al, 1999;Van Camp et al, 2006;Goloshevsky et al, 2007;Huttunen et al, 2008;Sanganahalli et al, 2009). Although most of the human fMRI studies employ the event-related task design that has a short stimulus duration, animal studies generally investigate the relationship between BOLD signals and evoked potentials with a stimulus duration of several tens of seconds (Brinker et al, 1999;Van Camp et al, 2006;Goloshevsky et al, 2007;Huttunen et al, 2008;Sanganahalli et al, 2009). Unlike BOLD studies, numerous optical studies performed using laser Doppler flowmetry (LDF) (Ngai et al, 1999;Matsuura and Kanno, 2001;Ureshi et al, 2004Ureshi et al, , 2005 and optical imaging (Devor et al, 2003;Martindale et al, 2003;Sheth et al, 2003Sheth et al, , 2004Jones et al, 2004;Hewson-Stoate et al, 2005;Martin et al, 2006) have investigated the hemodynamic responses such as CBF and deoxygenated hemoglobin changes to neuronal activity in the rat cortex with a short stimulus duration (2-5 s) (Matsuura and Kanno, 2001;Martindale et al, 2003;Sheth et al, 2003Sheth et al, , 2004Jones et al, 2004;Ureshi et al, 2004Ureshi et al, , 2005Hewson-Stoate et al, 2005;Martin et al, 2006).…”
Section: Introductionmentioning
confidence: 99%
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