2020
DOI: 10.3389/fcell.2020.00864
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Simultaneous Recruitment of Stem Cells and Chondrocytes Induced by a Functionalized Self-Assembling Peptide Hydrogel Improves Endogenous Cartilage Regeneration

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Cited by 24 publications
(11 citation statements)
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“…Six months postsurgery, defects were filled up with neocartilage tissue that had a smooth surface similar to the native tissue [ 82 ]. Lv et al attempted to integrate the neocartilage with the host tissue by using two custom-designed functionalized self-assembling peptide hydrogels, KLD-12 and KLPP [ 83 ]. These peptides possess a functionalized nanostructure with low cytotoxicity that induces chondrocyte and BMSC migration.…”
Section: The Role Of Biomolecules In Csimentioning
confidence: 99%
“…Six months postsurgery, defects were filled up with neocartilage tissue that had a smooth surface similar to the native tissue [ 82 ]. Lv et al attempted to integrate the neocartilage with the host tissue by using two custom-designed functionalized self-assembling peptide hydrogels, KLD-12 and KLPP [ 83 ]. These peptides possess a functionalized nanostructure with low cytotoxicity that induces chondrocyte and BMSC migration.…”
Section: The Role Of Biomolecules In Csimentioning
confidence: 99%
“…The specimen after subcutaneous implantation for 6 weeks was immersed in 10% neutral buffered formalin, washed with PBS, dehydrated, embedded in paraffin, cut into slices of a 5 ÎŒm thickness, and stained with hematoxylin and eosin. 5 ÎŒm slices were immunostained with a type II collagen antibody as previously described ( Lv et al, 2020 ).…”
Section: Methodsmentioning
confidence: 99%
“…[51] In addition, the novel bionic scaffold based on the developed KLD-12-LPP has also been proved to promote the migration of endogenous BM-SCs and chondrocytes at the same time, which is a promising one-step surgical strategy for the repair of endogenous cartilage defects. [52] However, there are few studies on their chiral structures and chiral inductive effects. As an ionic complementary peptide similar to RADA16 based on chiral đ›Œ-amino acids, the inductive role of the chiral structure of KLD12 in cartilage repair should be paid attention to.…”
Section: Bionic Scaffolds Of Sap Hydrogels Based On Kld12mentioning
confidence: 99%