Simultaneous serological screening for congenital cytomegalovirus and toxoplasma infection

Joss, A. W. L.; Skinner, Louise J.; Chatterton, J. M. W.; Chisholm, S M; Williams, H.; Ho-Yen, D. O.

doi:10.1016/s0033-3506(88)80078-7

Cited by 23 publications

(22 citation statements)

References 14 publications

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“…Longitudinal clinical and serological studies and horizontal surveys of specific IgM to T. gondii can provide data on incidence of infection in women of childbearing age [13,14], and surveillance programmes of infants and children have been used to assess numbers of cases of congenital infection [1,2]. Horizontal age-stratified serological studies which measure the levels of specific antibody prevalence serve as a good basis for assessing the risk of infection in a community [15,16].…”

Section: Introductionmentioning

confidence: 99%

Longitudinal study of toxoplasma seroprevalence in South Yorkshire

1992

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SUMMARYSerum samples collected from individuals of a wide range of ages in South Yorkshire between 1969 and 1990 provided the basis for a longitudinal seroprevalence survey of Toxoplasma gondii antibodies. Sera numbering 3868 were screened for T. gondii specific antibodies using a commercial latex agglutination test. The resultant temporal series of serological profiles revealed a rise, with age, in seroprevalence, the rate of which showed a decrease through time. A plateau of around 40-50% prevalence was attained by the 41-to 45-year age-class in 1969 which was not approached until the 66-to 70-year class in the 1988-90 data set. This trend for decline in seroprevalence was confirmed by statistical analysis for the age range 21-60 years. These results may be indicative of a decrease in the rate of toxoplasma exposure in this study community over the 20-year period. The survey of 1988-90 provides a base-line profile of present-day seroprevalence in which 11 % of individuals in the age range 16-45 years (roughly corresponding to the childbearing age-range) show evidence of past infection. The representative nature of the serum collection and public-health implications of these results are discussed.

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Section: Introductionmentioning

confidence: 99%

Longitudinal study of toxoplasma seroprevalence in South Yorkshire

1992

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“…Specific IgM tests are used routinely to diagnose maternal rubella Infection following a contact or a suspected contact in pregnancy. They have a similar role in cytomegalovirus (CMV), and have also been considered in the context of antenatal screening programmes for CMV [12]. Even Consider, firstly, a situation where the median IgM persistence following infection is equal to the gestational age at testing.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the sensitivity and predictive value of tests of recent infection: toxoplasmosis in pregnancy

Ades

1991

Epidemiol. Infect.

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SUMMARYThe diagnosis of maternal infection in early pregnancy depends on tests which are sensitive to recent infection, such as specific IgM. Two types of test are considered: those where the response persists for a period following infection and then declines, such as IgM, and those whose response increases with time since infection, such as IgG-avidity. However, individuals vary in their response to infection, and it may not always be possible to determine whether an infection occurred during pregnancy or before it. Mathematical methods are developed to evaluate the performance of these tests, and are applied to the diagnosis of toxoplasmosis in pregnancy. It is shown that, based on existing information, tests of recent infection are unlikely to be both sensitive and predictive. More data on these tests are required, before they can be reliably used to determine whether infection has occurred during pregnancy or before it.

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“…Specimens were also tested by indirect haemagglutination (HA; Thorburn and Williams, 1972) or ELISA IgG (Joss et al, 1988) followed by a micromodification of the dye test (DT; Williams et al, 1981) with titres expressed in International Units (IU)/ml. Specific IgM was investigated initially by indirect immunofluorescence and occasionally sucrose gradient fractionation followed by HA and DT on relevant fractions.…”

Section: Assaysmentioning

confidence: 99%

“…Sera were selected from those submitted to the laboratory for routine testing and others were collected for a prospective antenatal survey (Joss et al, 1988).…”

Section: Serum Samplesmentioning

confidence: 99%