Simultaneous Spectrophotometric Determination of Diflunisal and Diclofenac Sodium in Pharmaceutical Dosage Form Using Chemometric Methods

Habib, I. H. I.; Rizk, Mohamed; Mohamed, Dalia; Mowaka, Shereen; El-Eryan, Rasha Th.

doi:10.9734/bjpr/2016/26586

Cited by 3 publications

(4 citation statements)

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“…A comparison of the analytical parameters of the designed sensor with the previously reported sensors for the individual and simultaneous determination of the PAR, DIC, and ORP is given in Table . − ,,,,,,, The stripping method apart from its requirement of surface amendment of the electrode and preaccumulation steps present better analysis than other techniques. ,− ,− The LOD values for the target drugs attainable using the presented scheme are lower than the WHO-suggested limits , and those obtained by other sensors. Thus, our designed electrochemical nanosensor is highly promising in the context of sensitivity, selectivity, and stability than many metal/metal oxides NPs, carbon polyhedrons/shells, organic ligands, graphene, silica, inorganic/organic polymers, and their composites based on formerly reported sensors.…”

Section: Resultsmentioning

confidence: 89%

“…The methods recommended by British Pharmacopoeia for drugs determination involve aqueous and nonaqueous titrations. For specific/selective determination of the drugs, some analytical methods such as titrimetry, UV–vis spectrophotometry, capillary electrophoresis, high-performance liquid chromatography, fluorimetry, flow-injection analysis, and chemiluminescence are employed. − Though some of these techniques offer high selectivity and accuracy, the associated high cost, need for skilled operators, and tedious workup limit their applications. , To the best of our knowledge, there are no published reports about an effective method for the simultaneous femtomolar voltammetric determination of paracetamol, diclofenac, and orphenadrine (PAR, DIC, and ORP, respectively) in pharmaceutical forms or biological fluids. Keeping these in consideration, the development of simple, cost-effective, and potentially selective electrochemical sensing techniques has gained significant research interest for the simultaneous multianalyte detection .…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous Femtomolar Detection of Paracetamol, Diclofenac, and Orphenadrine Using a Carbon Nanotube/Zinc Oxide Nanoparticle-Based Electrochemical Sensor

Kokab

Shah

Khan

et al. 2021

ACS Appl. Nano Mater.

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The development of an efficient, selective, and highly sensitive electrochemical sensor for the simultaneous analysis of multiple drugs is a tough challenge. Herein, we report an applied electrochemical sensing platform comprising both acid-and base-functionalized carbon nanotubes (CNTs) with zinc oxide nanoparticles between the layers (COOH-CNTs/ ZnO/NH 2 -CNTs) for the detection of paracetamol, diclofenac, and orphenadrine (PAR, DIC, and ORP) drugs with ultrahigh sensitivity and selectivity as evidenced by intense and well-resolved voltammetric signals. Prior to electrochemical analysis, the nanocomposite/ glassy carbon electrode (GCE) surface was characterized by multiple spectroscopic techniques. The performance of f CNTs/ZnO/f CNTs/GCE was probed by electrochemical impedance spectroscopy (EIS), cyclic voltammetry (CV), and square-wave anodic stripping voltammetry (SWASV). The functionalized porous architecture with a large effective surface area provided a conduit for efficient mass transport and active sites for anchoring adsorbate molecules, thus leading to substantially lower oxidation overpotentials and amplified current signals. The f CNTs/ZnO/f CNTs/GCE exhibited a 6-fold increase in active surface area than bare GCE. Under optimized SWASV conditions, the designed sensor demonstrated simultaneous detection of PAR, DIC, and ORP with an unprecedented femtomolar limit of detection (46.8, 78, and 60 fM, respectively) within a time span of just 1 min. Besides the specificity, stability, and reliability studies of the designed sensing platform in multiple biological and pharmaceutical samples, % recoveries of 96−102% highlight the novelty and figures of merit of the designed electrochemical sensor. Moreover, computational studies were carried out that support the experimental outcome of a favorable charge transfer process between functional groups of the drugs and the sensor surface.

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Section: Resultsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Simultaneous Femtomolar Detection of Paracetamol, Diclofenac, and Orphenadrine Using a Carbon Nanotube/Zinc Oxide Nanoparticle-Based Electrochemical Sensor

Kokab

Shah

Khan

et al. 2021

ACS Appl. Nano Mater.

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“…The literature review for the determination of cited drugs includes spectrophotometry 4-7 , Habib et al 4 developed spectrophotometric methods for determination FEB in concentration range 2-10 µg/mL and DIC 2.5-25 µg/mL, while linear range of Modi et al 5 were 3-15 µg/mL and 6-30 µg/mL for FEB and DIC; respectively, and Derasari et al 6 determined FEB and DIC in concentration range 2-9 µg/mL and 5-22.5 µg/mL for FEB and DIC; respectively, On the other hand, El-Yazbi et al 7 developed spectrophotometric methods for determination of FEB and DIC in linear range 2-14 and 4-18 µg/mL for FEB and DIC; respectively, which give priority of the proposed methods to be determined FEB and DIC in wider range as our linear range 2-20 and 5-50 µg/mL for FEB and DIC; respectively, comparison between the proposed methods and other spectrophotometric reported methods was presented in table 5. The literature review showed also HPTLC and HPLC methods [7][8][9][10] for the determination of cited drugs, El-Yazbi et al developed two HPTLC methods and one HPLC method for determination of FEB and DIC 7-9. In the first one 7 used chloroform-methanol as mobile phase, in [8] used petroleum ether-chloroform-ethyl acetate-formic acid as mobile phase.…”

Section: Discussionmentioning

confidence: 99%

“…Few analytical techniques for simultaneous study of FEB and DIC were found in the literature review. These methods include: spectrophotometry [4][5][6][7] , HPTLC 7,8 and HPLC methods 9, 10 .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous resolution of febuxostat and diclofenac potassium in pure form and in their multi-ingredient formula.

Mahmoud

Fouad

El-Kosasy

2021

Azhar International Journal of Pharmaceutical and Medical Scien

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Easy, precise, and accurate three spectrophotometric procedures for successive resolution of febuxostat and diclofenac potassium in their multi-ingredient formula without prior separation were established and validated. Second derivative ( 2 D), dual-wavelength (DW), and ratio subtraction (RS) are the names of these procedures. They showed good linearity in the ranges of 2.0-20.0 µg/mL for febuxostat and 5.0-50.0 µg/mL for diclofenac potassium with strong determination coefficients (r 2 ). For 2 D (r 2 = 0.9995 -0.9998), DW (r 2 = 0.9997 -0.9998) and RS (r 2 = 0.9995 -0.9999) for febuxostat and diclofenac potassium; respectively. By using the proposed procedures, the limits of detection and the limits of quantitation for febuxostat and diclofenac potassium were 0.135-0.580 µg/mL and 0.408-1.756 µg/mL, respectively. They were also successfully used to test two drugs in their multi-ingredient formula, with the findings being checked, statistically analyzed, and found to be consistent with those obtained by a previously published method.

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Simultaneous square wave voltammetric determination of two anti-inflammatory drugs using a bare carbon paste electrode

El-Attar,

Fathi,

Habib

2024

Egyptian Pharmaceutical Journal

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Background Diclofenac (DIC) is a nonsteroidal anti-inflammatory drug (NSAID) that is more potent than indomethacin. There is an extended-release form of this drug available for long-term treatment. Diflunisal (DIF) is a NSAID with less anticoagulant activity than aspirin. It is more potent than aspirin and is not converted to salicylic acid in vivo. Objectives A simple, direct, and sensitive method for the simultaneous determination of two types of NSAIDs, namely, diclofenac ‘DIC’ and diflunisal ‘DIF’ by square wave adsorptive anodic stripping voltammetry and applied at the same time in synthetic and pharmaceutical samples. Materials and methods In this method, both cited ingredients were oxidized by a bare carbon paste electrode (CPE) forming two well-separated peaks at the potential of 0.65 and 0.85 V, respectively, in 0.04 M universal buffer solution at pH 5 with 100 mV/s scan rate by square wave adsorptive anodic stripping voltammetry technique with an Autolab system of potentiostat/galvanostat. Results and conclusion The prepared sensor showed good linear regression curves over the concentration ranges of 1–6 and 5–25 μg/ml for DIC and DIF, respectively, while the detection limit ‘LOD’ and quantification limit ‘LOQ’ and were 0.204 and 0.68 μg/ml for DIC and 1.366 and 4.553 μg/ml for DIF, in turn. The cited sensor was applied with accurate and precise results for determining DIC and DIF at the same time in synthetic and pharmaceutical samples and gave close results in comparison with the official method, specifically by UV-high performance liquid chromatography.

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Simultaneous Spectrophotometric Determination of Diflunisal and Diclofenac Sodium in Pharmaceutical Dosage Form Using Chemometric Methods

Cited by 3 publications

References 0 publications

Simultaneous Femtomolar Detection of Paracetamol, Diclofenac, and Orphenadrine Using a Carbon Nanotube/Zinc Oxide Nanoparticle-Based Electrochemical Sensor

Simultaneous Femtomolar Detection of Paracetamol, Diclofenac, and Orphenadrine Using a Carbon Nanotube/Zinc Oxide Nanoparticle-Based Electrochemical Sensor

Simultaneous resolution of febuxostat and diclofenac potassium in pure form and in their multi-ingredient formula.

Simultaneous square wave voltammetric determination of two anti-inflammatory drugs using a bare carbon paste electrode

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