Simultaneous synthesis of hydroxyapatite fibres and β-tricalcium phosphate particles <i>via</i> a water controlled-release solvothermal process

Goto, Tomoyo; Yin, Shu; Cho, Sunghun; Sekino, Tohru

doi:10.1039/d2ce01703b

CrystEngComm

2023

DOI: 10.1039/d2ce01703b

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Simultaneous synthesis of hydroxyapatite fibres and β-tricalcium phosphate particles via a water controlled-release solvothermal process

Tomoyo Goto

Shu Yin

Sunghun Cho

et al.

Abstract: Fibrous hydroxyapatite was synthesised from α-tricalcium phosphate in ethanol and acetic acid solutions via a water controlled-release solvothermal process (WCRSP). Rice-like particles of β-tricalcium phosphate were formed by adjusting the...

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Cited by 3 publications

References 30 publications

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In Vitro Osteogenic Response to Copper‐Doped Eggshell‐Derived Hyroxyapatite With Macrophage Supplements

Patil,

Patel,

Lim

2024

J Biomedical Materials Res

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The high bioactivity and biocompatibility of hydroxyapatite (HAP) make it a useful bone graft material for bone tissue engineering. However, the development superior osteoconductive and osteoinductive materials for bone regeneration remains a challenge. To overcome these constraints, Cu‐doped hydroxyapatite (HAP(Cu)) from waste eggshells has been produced for bone tissue engineering. The materials produced were characterized using Fourier transform infrared spectroscopy, x‐ray diffraction, and photoelectron spectroscopy. The scanning microscopy images revealed that the developed HAP was a rod‐like crystalline structure with a typical 80–150 nm diameter. Energy‐dispersive x‐ray spectroscopy showed that the generated HAP was mostly composed of calcium, oxygen, and phosphorus. The Ca/P molar ratios in eggshell‐derived and copper‐doped HAP were 1.61 and 1.67, respectively, similar to the commercially available HAP ratio (1.67). The WST‐8 assay was used to assess the biocompatibility of HAPs with hBMSCs. HAP(Cu) in the media significantly altered the cytotoxicity of biocompatible HAP(Cu). The osteogenic potential of HAP(Cu) was demonstrated by greater mineralization than that of pure HAP or the control. HAP(Cu) showed higher osteogenic gene expression than pure HAP and the control, indicating its stronger osteogenic potential. Furthermore, we assessed the effects of sample‐treated macrophage‐derived conditioned medium (CM) on hBMSCs' osteogenesis. CM‐treated HAP(Cu) demonstrated a significantly higher osteogenic potential vis‐à‐vis pure HAP(Cu). These findings revealed that HAP(Cu) with CM significantly improved osteogenesis in hBMSCs and can be explored as a bone graft in bone tissue engineering.

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In Vitro Osteogenic Response to Copper‐Doped Eggshell‐Derived Hyroxyapatite With Macrophage Supplements

Patil,

Patel,

Lim

2024

J Biomedical Materials Res

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show abstract

Synthesis and morphological control of Ca5(PO4)3Cl and Ca2PO4Cl via the phase transformation of amorphous calcium phosphate in molten chlorides

Kabasinskas,

Karoblis,

Griesiute

et al. 2024

Ceramics International

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Hydroxyapatite: A journey from biomaterials to advanced functional materials

Mondal,

Park,

Choi

et al. 2023

Advances in Colloid and Interface Science

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Simultaneous synthesis of hydroxyapatite fibres and β-tricalcium phosphate particles via a water controlled-release solvothermal process

Abstract: Fibrous hydroxyapatite was synthesised from α-tricalcium phosphate in ethanol and acetic acid solutions via a water controlled-release solvothermal process (WCRSP). Rice-like particles of β-tricalcium phosphate were formed by adjusting the...

Cited by 3 publications

References 30 publications

In Vitro Osteogenic Response to Copper‐Doped Eggshell‐Derived Hyroxyapatite With Macrophage Supplements

In Vitro Osteogenic Response to Copper‐Doped Eggshell‐Derived Hyroxyapatite With Macrophage Supplements

Synthesis and morphological control of Ca5(PO4)3Cl and Ca2PO4Cl via the phase transformation of amorphous calcium phosphate in molten chlorides

Hydroxyapatite: A journey from biomaterials to advanced functional materials

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