Simultaneous three-dimensional photoacoustic and laser-ultrasound tomography

Wurzinger, Gerhild; Nuster, Robert; Schmitner, Nicole; Gratt, Sibylle; Meyer, Dirk; Paltauf, Guenther

doi:10.1364/boe.4.001380

Cited by 35 publications

(20 citation statements)

References 39 publications

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“…In the clinic, imaging of the breast pendant in water as coupling medium is the most suitable application. An implementation can take the form of the preclinical designs allowing three-dimensional PA and ultrasound transmission imaging presented by Ermilov et al 22 Anis et al, 26 and Wurzinger et al 27 …”

Section: Discussionmentioning

confidence: 99%

Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic–ultrasound transmission tomography

Daoudi¹,

Es²,

Manohar³

et al. 2013

J. Biomed. Opt

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Abstract. Recently, we presented an add-on to a photoacoustic (PA) computed tomography imager that permits the simultaneous imaging of ultrasound (US) transmission parameters such as the speed of sound (SOS), without additional measurements or instruments. This method uses strong absorbers positioned outside the object in the path of light for producing laser-induced US to interrogate the object in a conventional PA imager. Here, we investigate the feasibility of using this approach, first with PA to pin-point the location of photothermal therapeutic agents and then with serial SOS tomograms to image and monitor the resulting local temperature changes when the agents are excited with continuous wave (CW) light. As the object we used an agar-based tissue-mimicking cylinder carrying beads embedded with different concentrations of gold nanospheres. PA and SOS tomograms were simultaneously acquired as the gold nanospheres were photothermally heated using a 532-nm CW laser. In a first approximation, using the relation between SOS of water and temperature, the SOS tomograms were converted into temperature maps. The experimental results were verified using simulations: Monte Carlo modeling of light propagation through a turbid medium and using the obtained absorbed energy densities in heat diffusion modeling for spatial temperature distribution.

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Section: Discussionmentioning

confidence: 99%

Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic–ultrasound transmission tomography

Daoudi¹,

Es²,

Manohar³

et al. 2013

J. Biomed. Opt

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“…The software operates in real time (frame rate is 10 Hz) and displays tomograms of an object located in the focal plane of the antenna. For the reconstruction of tomogram the filtered back-projection algorithm is used [10]. The algorithm constructs an image over "arcs of probability", which have a shape of parabolas.…”

Section: Experimental Methodsmentioning

confidence: 99%

A method of laser ultrasound tomography for solid surfaces mapping

et al. 2018

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Abstract. Surface control is an important problem for production inspection in industry. Traditionally it is solved using mechanical and optical profilometry, providing high spatial resolution. However, such methods are inappropriate for bodies immersed in opaque liquids and require preliminary preparation of samples. Current work focuses on an application of a method of laser ultrasound tomography to mapping of solid surfaces. The suggested approach combines high acoustical resolution, high performance and allows profilometry of contaminated and immersed samples. An automated prototype for real-time surface profile measurements is constructed and tested on several bodies of revolution. Linear approximation of a cylinder profile obtained by the prototype shows maximum approximation inconsistency of 15. The results are verified by those obtained by the conventional x-ray method.

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“…[21][22][23] In a previous work, we presented simultaneous PA and LUS pulse-echo tomography using a free-beam Mach-Zehnder interferometer for US detection. 24 In addition to its broad bandwidth, another big advantage of this detector is its transparency for traversing sound waves. This feature enables hybrid PA and LUS section imaging by adding an additional acoustic reflector as proposed by Nuster et al 25 The surface of this cylindrical mirror is covered with a lightabsorbing layer, where focused sound waves are generated upon illumination.…”

Section: Introductionmentioning

confidence: 99%

Combined photoacoustic, pulse-echo laser ultrasound, and speed-of-sound imaging using integrating optical detection

2016

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, "Combined photoacoustic, pulse-echo laser ultrasound, and speed-of-sound imaging using integrating optical detection," J. Biomed. Opt. Abstract. A purely optical setup for the coregistration of photoacoustic (PA), ultrasound (US), and speed-ofsound (SOS) section images is presented. It extends a previously developed method for simultaneous PA and laser-US (LUS) pulse-echo imaging with a LUS transmission imaging setup providing two-dimensional (2-D) SOS maps. For transmission imaging, the sound waves traversing the investigated object are generated instantaneously by illuminating optically absorbing targets that are arranged at various distances in front of the sample. All signals are recorded by an optical beam which is part of a Mach-Zehnder interferometer that integrates the acoustic field along its path. Due to the cascaded arrangement of LUS sources, a single-recorded signal yields information for a projection of the SOS distribution. After collection of data from all directions, an inverse Radon transform is applied to this set of projections to obtain a 2-D SOS image. The setup is characterized and its performance is tested on phantom experiments. In addition to providing additional contrast, it is also shown that the resolution of the coregistered PA and LUS images can be improved by implementing the knowledge of the SOS distribution in the reconstruction. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Simultaneous three-dimensional photoacoustic and laser-ultrasound tomography

Cited by 35 publications

References 39 publications

Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic–ultrasound transmission tomography

Two-dimensional spatiotemporal monitoring of temperature in photothermal therapy using hybrid photoacoustic–ultrasound transmission tomography

A method of laser ultrasound tomography for solid surfaces mapping

Combined photoacoustic, pulse-echo laser ultrasound, and speed-of-sound imaging using integrating optical detection

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