Simultaneous UV Spectrophotometric Methods for Estimation of Carvedilol and Hydrochlorothiazide in Bulk and Tablet Dosage Form

Mali, Audumbar Digambar; Kekan, Vikas; Dongare, Rohan; Gholve, Sachin B.; Bathe, Ritesh

doi:10.5958/2231-5713.2016.00002.7

Cited by 8 publications

(8 citation statements)

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“…The spectrophotometric signal of metformin standard solution (5–50 μg/mL) was measured at 236 nm in an LVS-A20 UV–visible spectrophotometer (LABTRON, U.K.) . Drug samples (30 μg/mL) were prepared in distilled water from 500 mg tablets.…”

Section: Experimental Sectionmentioning

confidence: 70%

“…The LoD and LoQ of the spectrophotometric method were 0.75 and 2.45 μg/mL, respectively. 40 The amount of metformin in each tablet determined using the spectrophotometric method was 483.8 ± 21.1 mg/tablet (range: 419.0−516.0 mg, see Figure 6). Based on the spectrophotometric measurement, only one sample was found to be not within the acceptable range suggested by the Pharmacopoeia (Table S3).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…The calibration curve of metformin determination using the spectrophotometric method is given in Figure S1. The LoD and LoQ of the spectrophotometric method were 0.75 and 2.45 μg/mL, respectively . The amount of metformin in each tablet determined using the spectrophotometric method was 483.8 ± 21.1 mg/tablet (range: 419.0–516.0 mg, see Figure ).…”

Section: Results and Discussionmentioning

confidence: 99%

“…The spectrophotometric signal of metformin standard solution (5–50 μg/mL) was measured at 236 nm in an LVS-A20 UV–visible spectrophotometer (LABTRON, U.K.). 40 Drug samples (30 μg/mL) were prepared in distilled water from 500 mg tablets. One tablet from each sample was crushed into fine powder using a pestle and was dissolved in 5mL of water.…”

Section: Experimental Sectionmentioning

confidence: 99%

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Handmade Paper as a Paper Analytical Device for Determining the Quality of an Antidiabetic Drug

et al. 2022

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Paper analytical devices (PADs) are a class of low-cost, portable, and easy-to-use platform for several analytical tests in clinical diagnostics, environmental pollution monitoring, and food and drug safety screening. These devices are primarily made from cellulosic paper. Considering the importance of eco-friendly and local or distributed manufacturing of devices realized during the COVID-19 pandemic, we systematically studied the potential of handmade Nepali paper to be used in fabricating PADs in this work. We characterized five different handmade papers made from locally available plant fibers using an eco-friendly method and used them to fabricate PADs for determining the drug quality. The thickness, grammage, and apparent density of the paper samples ranged from 198.6 to 314.8 μm, 49.1 to 117.8 g/m 2 , and 0.23 to 0.43 g/cm 3 , respectively. The moisture content, water filtration, and wicking speed ranged from 5.8 to 7.1%, 35.7 to 156.7, and 0.062 to 0.124 mms –1 , respectively. Furthermore, the water contact angle and porosity ranged from 76.6 to 112.1° and 79 to 83%, respectively. The best paper sample (P5) was chosen to fabricate PADs for the determination of metformin, an antidiabetic drug. The metformin assay on PADs followed a linear range from 0.0625 to 0.5 mg/mL. The assay had a limit of detection and limit of quantitation of 0.05 and 0.18 mg/mL, respectively. The average amount of metformin concentration in samples collected from local pharmacies ( n = 20) was 465.6 ± 15.1 mg/tablet. When compared with the spectrophotometric method, PAD assay correctly predicted the concentration of 90% samples. The PAD assay on handmade paper may provide a low-cost and easy-to-use system for screening the quality of drugs and other point-of-need applications.

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Section: Experimental Sectionmentioning

confidence: 70%

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Results and Discussionmentioning

confidence: 99%

Section: Experimental Sectionmentioning

confidence: 99%

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Handmade Paper as a Paper Analytical Device for Determining the Quality of an Antidiabetic Drug

et al. 2022

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“…Calibration curve of metformin determination using spectrophotometric method is given in Figure S1. The LoD and LoQ of spectrophotometric method were 0.75 µg/mL and 2.45 µg/mL respectively 43 . Amount of metformin in each tablets determined using spectrophotometric method was 483.8 ± 21.1 mg (range: 419.0 -516.0 mg, see Figure 6).…”

Section: 1mentioning

confidence: 96%

Characterization of handmade Nepali paper as a platform for paper analytical device to determine anti-diabetic drug

Bhattarai¹,

Pudasaini²,

Sah³

et al. 2021

Preprint

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The COVID-19 pandemic has highlighted the need of eco-friendly and locally or distributed manufacturing of diagnostic and safety products. Here, we characterized five handmade papers for their potential application to make paper analytical device (PADs). The handmade papers were made from locally available plant fiber using eco-friendly method. Thickness, grammage, and apparent density of the paper samples ranged from 198 μm to 314 μm, 49 g/m2 to 117.8 g/m2, and 0.23 to 0.39 g/cm3, respectively. Moisture content, water filtration and wicking speed ranged from 5.2% to 7.1%, 35.7 to 156.7, and 0.062 to 0.124 mms-1, respectively. Further, water contact angle and porosity ranged from 76˚ to 112˚ and 79% to 83%, respectively. The best paper sample one was chosen to fabricate PADs which were used for the determination of metformin. The metformin assay on PADs followed linear range from 0.0625 to 0.5 mg/mL. The assay had limit of detection and limit of quantitation of 0.05 mg/mL and 0.18 mg/mL respectively. The new method was used to test metformin samples (n=20) collected from local pharmacies. The average amount of metformin concentration in samples was 465.6 ± 15.1mg/tablet. Three samples did not meet the regulatory standards. When compared with spectrophotometric method, PADs assay correctly predicted 18 out of 20 samples. The PADs assay on handmade paper may provide a low-cost and easy-to-use system to screening the quality of drugs and other point-of-need applications.

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An eco-friendly strategy, using on-line monitoring and dilution coupled to a second-order chemometric method, for the construction of dissolution curves of combined pharmaceutical associations

Calvo

Maggio

Kaufman

2014

Journal of Pharmaceutical and Biomedical Analysis

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Simultaneous UV Spectrophotometric Methods for Estimation of Carvedilol and Hydrochlorothiazide in Bulk and Tablet Dosage Form

Cited by 8 publications

References 0 publications

Handmade Paper as a Paper Analytical Device for Determining the Quality of an Antidiabetic Drug

Handmade Paper as a Paper Analytical Device for Determining the Quality of an Antidiabetic Drug

Characterization of handmade Nepali paper as a platform for paper analytical device to determine anti-diabetic drug

An eco-friendly strategy, using on-line monitoring and dilution coupled to a second-order chemometric method, for the construction of dissolution curves of combined pharmaceutical associations

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