Simultaneously Occurring Oligodendroglioma and Meningioma in a Dog

First report of the simultaneous occurrence of choroid plexus papilloma and meningioma in a dog

“…In human medicine, since the first report in 1938, less than 150 cases have been described in the literature (Tugcu et al, 2006). To the author's knowledge, the presence of two different spontaneous primary brain tumours has been described in only three dogs so far (Stacy et al, 2003;Snyder et al, 2006;Mackillop et al, 2007). There are several hypotheses explaining the association of different primary brain tumours: (1) embryonic residual, (2) systemic carcinogen, 3) carcinogenic stimulus, 4) growth hormone stimulation, and 5) one tumour acting as an irritating agent for the development of the other; however, none of these hypotheses have been proved (Bunick et al, 1978;Zenkel et al, 1992;Tugcu et al, 2006).…”

“…The associations of meningioma and glioma, meningioma and brain metastases and meningioma and pituitary adenoma were found to be the most common in different studies in humans (Davis et al, 1995;Goyal et al, 2003;Maiuri et al, 2005). Although meningioma has been associated with nine different types of intracranial tumours, the association of meningioma and choroid plexus papilloma has never been reported, to the best of the author's knowledge, either in human or in veterinary medicine (Stacy et al, 2003;Maiuri et al, 2005;Alves et al, 2006;Banka et al, 2007). This short communication describes the clinical, neuroimaging and pathological features of a spontaneously occurring meningioma and choroid plexus papilloma arising simultaneously in separate sites in the brain of a dog.…”

“…An annual incidence in the general population can be expected to be much less than 1 per million, solely based on the annual incidence rates of 10-15 cases per 100,000 who develop primary brain tumours (Zülch, 1986;Hassad and Al-Mefty, 1996). The presence of two different spontaneous primary brain tumours was described only in three dogs (Stacy et al, 2003;Snyder et al, 2006;Mackillop et al, 2007). These authors reported an oligodendroglioma and a meningioma (Stacy et al, 2003), a meningioma and an astrocytoma (Snyder et al, 2006), and a medulloblastoma and an astrocytoma (Mackillop et al, 2007) arising simultaneously at separate sites in the brain.…”

“…The presence of two different spontaneous primary brain tumours was described only in three dogs (Stacy et al, 2003;Snyder et al, 2006;Mackillop et al, 2007). These authors reported an oligodendroglioma and a meningioma (Stacy et al, 2003), a meningioma and an astrocytoma (Snyder et al, 2006), and a medulloblastoma and an astrocytoma (Mackillop et al, 2007) arising simultaneously at separate sites in the brain. The associations of meningioma and glioma, meningioma and brain metastases and meningioma and pituitary adenoma were found to be the most common in different studies in humans (Davis et al, 1995;Goyal et al, 2003;Maiuri et al, 2005).…”

Metachronous primary cranial tumors: Temporal lobe oligodendroglioma and temporal bone epidermoid carcinoma

“…7 Previously, the association of brain oligodendroglioma and menengioma was demonstrated in humans and dogs. 4,8 In the literature, a case with an association of anaplastic oligodendroglioma at frontal lobe of brain and a squamous cell carcinoma at tongue was discussed. 1 However, best to our knowledge, the association of temporal lobe oligodendroglioma and temporal bone epidermoid carcinoma hasn't been demonstrated so far.…”