Simultaneously Presenting Head and Neck and Lung Cancer: A Diagnostic and Treatment Dilemma

Abstract

The presence of simultaneous head and neck squamous cell carcinoma and pulmonary malignancies should not be a deterrent to aggressive surgical therapy because a potentially satisfactory outcome can be expected in these patients.

Lung cancer patients with previous or simultaneous urologic cancers

“…Extra-pulmonary cancers associated with lung cancer occur most commonly in the upper aero-digestive tract [3][4][5], whereas lung cancer patients with urologic cancers seem to be rare [6][7][8][9]. In our present study, we identified 13 (1.2%) of lung cancer patients with previous or simultaneous urological cancers.…”

“…Lung cancer patients sometimes have other malignancies [1][2][3][4][5][6][7][8][9]. Among them, urologic cancers such as kidney cancer and cancer of the renal pelvis are incidentally detected during the workup of primary lung cancer.…”

Clinical Factors Related to Suspected Second Primary Lung Cancer Development in Patients with Head and Neck Cancer

“…Approximately 1% of head and neck squamous cell carcinomas (SCCs) are also associated with synchronous lung cancers (6). A second primary lung cancer in conjunction with an HNC is related to poor survival due to the advanced stage at time of diagnosis (7).…”

Simultaneous Triple Primary Head and Neck Malignancies: A Rare Case Report

“…Carey has countered that 'field cancerization' may be monoclonal with second tumours developing from micrometastatic deposits from original primary [6]. The majority of these second tumours develop in the upper aerodigestive tract, with lung cancer as the most frequently diagnosed malignancy [7]. However, simultaneous three primary malignancies of different histologic origin (as in the present case) in the head neck region may not be explained by these proposed theories.…”