Simvastatin reverses the harmful effects of high fat diet on titanium rod osseointegration in ovariectomized rats

Sun, Tao; Xing, Hai-Lin; Chen, Zhenzhong; Tao, Zhou-Shan; Li, Jian

doi:10.1007/s00774-021-01243-0

Cited by 6 publications

(2 citation statements)

References 34 publications

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“…Previous studies have shown that the systemic use of statins is beneficial to implant osseointegration even under hyperlipidemic conditions [52][53][54][55]. However, the bioavailability of statins in bone tissue is low, which means that the systemic use of statins requires administration of large doses, thus enhancing side effects [43].…”

Section: Local Drugs Injectionmentioning

confidence: 99%

Effects of Hyperlipidemia on Osseointegration of Dental Implants and Its Strategies

Sun

Meng

Chen

et al. 2023

JFB

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Hyperlipidemia refers to the abnormal increase in plasma lipid level exceeding the normal range. At present, a large number of patients require dental implantation. However, hyperlipidemia affects bone metabolism, promotes bone loss, and inhibits the osseointegration of dental implants through the mutual regulation of adipocytes, osteoblasts, and osteoclasts. This review summarized the effects of hyperlipidemia on dental implants and addressed the potential strategies of dental implants to promote osseointegration in a hyperlipidemic environment and to improve the success rate of dental implants in patients with hyperlipidemia. We summarized topical drug delivery methods to solve the interference of hyperlipidemia in osseointegration, which were local drug injection, implant surface modification and bone-grafting material modification. Statins are the most effective drugs in the treatment of hyperlipidemia, and they also encourage bone formation. Statins have been used in these three methods and have been found to be positive in promoting osseointegration. Directly coating simvastatin on the rough surface of the implant can effectively promote osseointegration of the implant in a hyperlipidemic environment. However, the delivery method of this drug is not efficient. Recently, a variety of efficient methods of simvastatin delivery, such as hydrogels and nanoparticles, have been developed to boost bone formation, but few of them were applied to dental implants. Applicating these drug delivery systems using the three aforementioned ways, according to the mechanical and biological properties of materials, could be promising ways to promote osseointegration under hyperlipidemic conditions. However, more research is needed to confirm.

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Section: Local Drugs Injectionmentioning

confidence: 99%

Effects of Hyperlipidemia on Osseointegration of Dental Implants and Its Strategies

Sun

Meng

Chen

et al. 2023

JFB

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“…Osteoporosis is a disease characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to enhanced bone fragility and consequent increase in fracture risk. 1 Osteoporosis is a major public health problem in many countries because the aged population has been growing in recent years 2 The prevalence of osteoporosis and the incidence of age-related fragility fracture vary by other underlying diseases [3][4][5] Remarkable advances in orthopedic surgical techniques and instruments have been achieved. However, loosening of the prosthesis after joint prosthesis replacement is still very high.…”

Section: Introductionmentioning

confidence: 99%

Local treatment with Sema3a could promote the osseointegration of hydroxyapatite coated titanium rod in diabetic rats

Wang

Wei

2022

J Biomater Appl

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Recently, semaphorin 3A (Sema3A) has been identified as a critical gene for osteogenic differentiation of mesenchymal stem cells and increases osteoblastic bone formation. However, in current research studies, there is a lack of focus on whether Sema3a can affect the osseointegration of titanium rods in diabetes and through what biological mechanisms. Therefore, the present work was aimed to evaluate the effect of local administration with Sema3A on hydroxyapatite coated titanium rod osseointegration in diabetic rat model and preliminary exploration of possible mechanisms. The MC3T3-E1 cells were co-cultured with Sema3A and high glucose and induced to osteogenesis, and the cell viability, osteogenic activity was observed by Cell Counting Kit-8(CCK-8), Alkaline Phosphatase staining, Alizarin Red Staining, and Western Blot. In vitro experiments, CCK-8, ALP, and ARS staining results show that the mineralization and osteogenic activity of MC3T3-E1increased significantly after intervention by Sema3A, as well as a higher levels of protein expressions including Runt-Related Transcription Factor 2, silent mating type information regulation 2 homolog-1(SIRT1), catalase (CAT), superoxide dismutase 1 (SOD1), and superoxide dismutase 2 (SOD2). In vivo experiment, a better stability and osseointegration of the titanium rod were observed after treatment with Sema3A, as well as a higher SOD1, SOD2, CAT, and SIRT1 gene expression. The present study indicates that local treatment with Sema3A was associated with increased osseointegration of titanium rod by reducing the oxidative stress of osteoblasts and enhancing the function of osteoblasts in a diabetic rat.

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Silymarin prevents iron overload induced bone loss by inhibiting oxidative stress in an ovariectomized animal model

Tao

Li²,

Wei³

2022

Chemico-Biological Interactions

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Simvastatin reverses the harmful effects of high fat diet on titanium rod osseointegration in ovariectomized rats

Cited by 6 publications

References 34 publications

Effects of Hyperlipidemia on Osseointegration of Dental Implants and Its Strategies

Effects of Hyperlipidemia on Osseointegration of Dental Implants and Its Strategies

Local treatment with Sema3a could promote the osseointegration of hydroxyapatite coated titanium rod in diabetic rats

Silymarin prevents iron overload induced bone loss by inhibiting oxidative stress in an ovariectomized animal model

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