Sind Fibromyalgiepatienten "hypervigilant"?

Dohrenbusch, Ralf

doi:10.1007/s004820170047

Cited by 10 publications

(2 citation statements)

References 28 publications

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“…In MB increased pain thresholds as compared to control subjects were found. The first result is in line with previous findings indicating differences between FMS patients and control subjects to intense [18], [27] but not to weak stimulation [28]. These data led to the hypothesis that in FMS an inhibitory system which prevents healthy subjects from overstimulation might be deficient.…”

Section: Discussionsupporting

confidence: 89%

Differential Effects of Painful and Non-Painful Stimulation on Tactile Processing in Fibromyalgia Syndrome and Subjects with Masochistic Behaviour

et al. 2010

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BackgroundIn healthy subjects repeated tactile stimulation in a conditioning test stimulation paradigm yields attenuation of primary (S1) and secondary (S2) somatosensory cortical activation, whereas a preceding painful stimulus results in facilitation.Methodology/Principal FindingsSince previous data suggest that cognitive processes might affect somatosensory processing in S1, the present study aims at investigating to what extent cortical reactivity is altered by the subjective estimation of pain. To this end, the effect of painful and tactile stimulation on processing of subsequently applied tactile stimuli was investigated in patients with fibromyalgia syndrome (FMS) and in subjects with masochistic behaviour (MB) by means of a 122-channel whole-head magnetoencephalography (MEG) system. Ten patients fulfilling the criteria for the diagnosis of FMS, 10 subjects with MB and 20 control subjects matched with respect to age, gender and handedness participated in the present study. Tactile or brief painful cutaneous laser stimuli were applied as conditioning stimulus (CS) followed by a tactile test stimulus (TS) 500 ms later. While in FMS patients significant attenuation following conditioning tactile stimulation was evident, no facilitation following painful stimulation was found. By contrast, in subjects with MB no attenuation but significant facilitation occurred. Attenuation as well as facilitation applied to cortical responses occurring at about 70 ms but not to early S1 or S2 responses. Additionally, in FMS patients the amount of attenuation was inversely correlated with catastrophizing tendency.ConclusionThe present results imply altered cortical reactivity of the primary somatosensory cortex in FMS patients and MB possibly reflecting differences of individual pain experience.

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Section: Discussionsupporting

confidence: 89%

Differential Effects of Painful and Non-Painful Stimulation on Tactile Processing in Fibromyalgia Syndrome and Subjects with Masochistic Behaviour

et al. 2010

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“…Thus, the observed effects may not be specific to chronic pain in general or FMS in particular. On the other hand, several experimental investigations failed to find any evidence for behaviorally relevant hypervigilance in patients with FMS ([34], [35], for review see [54]). Whereas those studies evaluated the attentional bias regarding innocuous somatosensory [35] or threatening linguistic stimuli [34], the present study is the first to assess the pain-related attentional bias in FMS using a behavioral paradigm with concurrent painful stimulation, which is well suited to study pain-related attentional interference.…”

Section: Discussionmentioning

confidence: 99%

Behavioral and Neuronal Investigations of Hypervigilance in Patients with Fibromyalgia Syndrome

et al. 2012

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Painful stimuli are of utmost behavioral relevance and thereby affect attentional resources. In health, variable effects of pain on attention have been observed, indicating alerting as well as distracting effects of pain. In the human brain, these effects are closely related to modulations of neuronal gamma oscillations. As hypervigilance as an abnormal increase of attention to external stimuli has been implicated in chronic pain states, we assumed both attentional performance and pain-induced gamma oscillations to be altered in patients with fibromyalgia syndrome (FMS). We recorded electroencephalography from healthy subjects (n = 22) and patients with FMS (n = 19) during an attention demanding visual reaction time task. In 50% of the trials we applied painful laser stimuli. The results of self-assessment questionnaires confirm that patients with FMS consider themselves hypervigilant towards pain as compared to healthy controls. However, the experimental findings indicate that the effects of painful stimuli on attentional performance and neuronal gamma oscillations do not differ between patients and healthy subjects. We further found a significant correlation between the pain-induced modulation of visual gamma oscillations and the pain-induced modulation of reaction times. This relationship did not differ between groups either. These findings confirm a close relationship between gamma oscillations and the variable attentional effects of pain, which appear to be comparable in health and disease. Thus, our results do not provide evidence for a behavioral or neuronal manifestation of hypervigilance in patients with FMS.

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Fibromyalgie

Petzke¹

2015

Schmerzmanagement in Der Pflege

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Sind Fibromyalgiepatienten "hypervigilant"?

Abstract: On the whole the existing studies argue against the assumption of trait-like hypervigilant information processing in FM-patients. A more appropriate explanation of the results is in terms of the interaction of situational and personal factors.

Cited by 10 publications

References 28 publications

Differential Effects of Painful and Non-Painful Stimulation on Tactile Processing in Fibromyalgia Syndrome and Subjects with Masochistic Behaviour

Differential Effects of Painful and Non-Painful Stimulation on Tactile Processing in Fibromyalgia Syndrome and Subjects with Masochistic Behaviour

Behavioral and Neuronal Investigations of Hypervigilance in Patients with Fibromyalgia Syndrome

Fibromyalgie

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