Síndrome de Erasmus – silicose e esclerose sistêmica

Miranda, Aryádine Allinne Machado de; Nascimento, Alice Carvalho; Peixoto, Isy Lima; Scrignoli, Juliana Alves; Cardoso, Maria do Socorro de Lucena; Ribeiro, Sandra Lúcia Euzébio

doi:10.1590/s0482-50042013000300010

Cited by 10 publications

(19 citation statements)

References 9 publications

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“…When the bronchioloalveolar lining infiltrated by macrophages and epithelial cells in high activity begins to produce a high amount of free radicals superior to the antioxidant mechanism performed by surfactants in this pulmonary alveolus, type I pneumocyte damage and increased proliferation of type II pneumocytes may occur [6].…”

Section: Discussionmentioning

confidence: 99%

“…Inhalation of silica particles is related to the development of different pathologies such as silicosis, chronic renal failure, chronic lung disease and simultaneously increased risk of development of pulmonary tuberculosis and also autoimmune diseases, such as rheumatoid arthritis, systemic lupus erythematosus and, as evidenced in this case, systemic sclerosis [6]. Thus, it is believed that, although Erasmus syndrome is not fully understood, the constant pulmonary inflammatory state due to contact with silica may be responsible for generating the immune response of affected patients.…”

Section: Introductionmentioning

confidence: 99%

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Erasmus syndrome presented as CREST syndrome with Scl-70 positivity: a case report

Pereira¹,

Portilho²,

Meira³

et al. 2021

BJCR

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Erasmus syndrome is a rare pathology defined as a systemic sclerosis secondary to contact with silica, associated or not with silicosis. More recent studies have related silica as an environmental factor stimulating different immune responses of the body. This report was made with the objective of presenting a rare case of systemic sclerosis, in a localized cutaneous form, also called CREST syndrome. A patient with a 20-year history of mining developed silicosis, cutaneous calcinosis, Raynauld's phenomenon, esophagopathy, sclerodactyly, telangiectasias and high positivity for the antitopoisomerase I antibody, the most common antibody in the systemic form.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Erasmus syndrome presented as CREST syndrome with Scl-70 positivity: a case report

Pereira¹,

Portilho²,

Meira³

et al. 2021

BJCR

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“…Later, it was called Caplan’s syndrome in several reports, including from Korea [ 12 , 13 ]. Systemic sclerosis was first described by Erasmus in 1957, after which additional reports described it as Erasmus syndrome [ 14 , 15 ]. Systemic lupus erythematosus (SLE) was reported by Conrad in 1996 in a uranium mine cohort study, and Yamazaki reported a case in 2007 in which short exposure for a few months caused SLE in miners [ 16 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

Overlap syndrome with Sjögren’s syndrome and systemic sclerosis in a steel rolling mill worker: a case report

Choi

Han

et al. 2016

Ann of Occup and Environ Med

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BackgroundThere are few reports about work-related factors associated with Sjögren’s syndrome. We report a case of overlap syndrome with Sjögren’s syndrome and systemic sclerosis.Case presentationA 54-year-old man was admitted due to dyspnea on exertion. The results of physical examination and laboratory findings were compatible with Sjögren’s syndrome with systemic sclerosis. The patient had no pre-existing autoimmune disease, and denied family history of autoimmune disease. The patient worked in the large-scale rolling department of a steel manufacturing company for 25 years. Hot rolling is a rolling process performed at between 1100 °C and 1200 °C, generating a high temperature and a large amount of fumes, involving jet-spraying of water throughout the process to remove the instantaneously generated oxide film and prevent the high generation of fumes. In this process, workers could be exposed to silica produced by thermal oxidation. Other potential toxic substances including nickel and manganese seemed to be less likely associated with the patient’s clinical manifestations.ConclusionsOccupational exposure to silica seemed to be associated with the patient’s clinical manifestations of overlap syndrome with Sjögren’s syndrome and systemic sclerosis. Although the underlying mechanism is still unclear, autoimmune disease including Sjögren’s syndrome affects women more often than men and there was no family history of autoimmune disease. These suggested that there was an association between occupational silica exposure and the disease of the patient. Future research about the association between long-term low dose exposure to silica and the development of autoimmune diseases should be encouraged.

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“…Erasmus soulignait la fréquence particulière de la ScS chez ces mineurs, comparée à celle observée dans un groupe témoin [ 9 ]. L’association d’une exposition à la silice (avec ou sans silicose) avec la ScS porte depuis le nom de « syndrome d’Erasmus » [ 9 , 10 ]. En 1967, Rodnan et al [ 11 ] confirmaient cette association en rapportant, sur 60 cas de sclérodermies masculines, une exposition prolongée à la poussière de silice chez 26 des patients (soit 43 %).…”

Section: Discussionunclassified

Sclérodermie systémique associée à l’exposition à la silice survenant après une exposition professionnelle à la soudure à l’arc

Alaya¹,

Kalboussi²,

Osman³

et al. 2016

Pan Afr Med J

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La sclérodermie systémique liée à l’exposition à la silice cristalline peut apparaître chez les personnes utilisant la soudure à l’arc. Une forme diffuse de sclérodermie a été diagnostiquée chez un plombier-soudeur de 57 ans, qui présentait des polyarthralgies inflammatoires, un phénomène de Raynaud, une sclérodactylie, une sclérose cutanée diffuse, des télangiectasies, une atteinte œsophagienne, une hypertension artérielle pulmonaire et une fibrose pulmonaire associées à la présence d’anticorps anti-nucléosomes. Au cours de son activité professionnelle, le patient était fréquemment exposé à des concentrations atmosphériques élevées de silice cristalline lors de la soudure à l’arc. Le diagnostic d’un syndrome d’Erasmus avec une association d’une sclérodermie systémique à une silicose pulmonaire était retenu. Une déclaration en maladie professionnelle au titre du tableau n°17 en Tunisie a été réalisée.

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Síndrome de Erasmus – silicose e esclerose sistêmica

Cited by 10 publications

References 9 publications

Erasmus syndrome presented as CREST syndrome with Scl-70 positivity: a case report

Erasmus syndrome presented as CREST syndrome with Scl-70 positivity: a case report

Overlap syndrome with Sjögren’s syndrome and systemic sclerosis in a steel rolling mill worker: a case report

Sclérodermie systémique associée à l’exposition à la silice survenant après une exposition professionnelle à la soudure à l’arc

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