Síndrome de Fanconi y raquitismo hipofosfatémico asociado al uso de tenofovir en una niña infectada con VIH

Zúñiga, Marcela; Galindo, A Héctor; Galaz, María Isabel; Vivanco, Maritza; Romero, Patricio; Balboa, Paulina; Torrejón, Claudia

doi:10.1016/j.rchipe.2016.08.001

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…For example, Tenofovir is the most frequently used component for HAART recommended by WHO. Concurrently, it has been reported that Tenofovir affects human kidney due to its renal toxicity and causing Fanconi’s syndrome, reduction in the glomerular filtration rate (eGFR) and acute kidney injury (AKI) 3–6 . Hence, less nephrotoxic drugs and simultaneously frequent monitoring of the kidney is preferable for HAART treatment in the Asian Scenario 7 .…”

Section: Introductionmentioning

confidence: 99%

In vitro anti-HIV-1 activity of the bioactive compound extracted and purified from two different marine macroalgae (seaweeds) (Dictyota bartayesiana J.V.Lamouroux and Turbinaria decurrens Bory)

Elumalai

Venkatasubramanian²,

Anbalagan³

et al. 2019

Sci Rep

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Highly active antiretroviral therapy (HAART) is the only available remedial measure to treat HIV infected patients, as recognized by the WHO. However, it is associated with toxicity (nephrotoxicity), high cost and most preferably drug resistance in the first-line treatment. Wherefore, potential and novel natural source is the only option for the modern world to challenge this global issue. In recent years, sulfated polysaccharide from marine macroalgae shown to be biologically active as anti-inflammatory, anticoagulant, antitumor, immunomodulatory and antiviral agents. As a direct inhibitor of HIV including other retroviruses, it is considered as a “new generation antiretroviral drug”. In our present study, Fucoidan, a sulfated polysaccharide has been extracted from two different macroalgae Dictyota bartayesiana (DD) and Turbinaria decurrens (TD) based on hot water extraction method and further confirmed by FT-IR and RP-HPLC methods. Both the crude and purified fucoidan samples were evaluated for anti-HIV activity after ion exchange chromatography purification. The maximum inhibitory activity of crude and purified fucoidan samples are 90.5% and 89% in the fucoidan extracts of DD. Whereas, it was 89.7% and 92% in the fucoidan extracts of TD. Simultaneously, the IC 50 values were determined and recorded as 1.56 µg/ml and 57.6 ng/ml in both the crude and purified fucoidan extracts of DD respectively. Similarly, for TD, it was 3 µg/ml and 131.7 ng/ml in the fucoidan extracts of TD. Therefore, further extensive research work is the most needful to fill the gaps to develop this sulfated polysaccharide as a potential drug for the treatment of HIV patients.

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Section: Introductionmentioning

confidence: 99%

In vitro anti-HIV-1 activity of the bioactive compound extracted and purified from two different marine macroalgae (seaweeds) (Dictyota bartayesiana J.V.Lamouroux and Turbinaria decurrens Bory)

Elumalai

Venkatasubramanian²,

Anbalagan³

et al. 2019

Sci Rep

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“…Un síndrome de malabsorción era improbable por los niveles normales de 25 (OH) D 3 y la ausencia de síntomas gastrointestinales; no se solicitaron anticuerpos anti endomisio ni anti transglutaminasa. Se descartó síndrome de Fanconi por la ausencia de otras pérdidas tubulares (9). Entre otros, no se encontró glucosuria, hipercalciuria ni acidosis metabólica.…”

Section: Rev Med Hered 2019; 30:262-266 265unclassified

Neumonía a repetición en un paciente con deformidades óseas: a propósito de un caso de raquitismo

Zapata-Chica¹,

Ramírez²,

Rodríguez-Ballesteros³

et al. 2020

Rev Med Hered

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El raquitismo es una enfermedad ósea infrecuente asociada a la disminución de niveles séricos de calcio o fosfato, la mayoría de los casos como consecuencia de déficit nutricional, aunque puede presentarse por mutaciones genéticas o defectos adquiridos del metabolismo. El cuadro clínico es heterogéneo y depende de la edad de presentación; manifestándose con ensanchamiento y retraso de la mineralización de la placa de crecimiento ósea. Se presenta el caso de un niño indígena de 11 meses de edad con historia de neumonía recurrente, al examen físico, presentaba hipotonía muscular generalizada, tórax con rosario costal y deformidad en extremidades, con paraclínicos: hipocalcemia e hipofosfatemia, fosfatasa alcalina y hormona paratiroidea elevadas, niveles de 25-hidroxi-vitamina D3 normales-altos y con valor de 1,25-dihidroxi-vitamina D3 muy bajo, se sugirió el diagnóstico de raquitismo dependiente de vitamina D tipo 1A severo, una forma infrecuente de esta patología.

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Changes in renal function with long‐term exposure to antiretroviral therapy in HIV‐infected adults in Asia

Joshi¹,

Boettiger

Kerr

et al. 2018

Pharmacoepidemiology and Drug

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Introduction: Renal disease is common amongst people living with HIV. However, there is limited information on the incidence and risk factors associated with renal dysfunction among this population in Asia. Methods: We used data from the TREAT Asia HIV Observational Database. Patients were included if they started antiretroviral therapy (ART) during or after 2003, had a serum creatinine measurement at ART initiation (baseline) and had at least two follow-up creatinine measurements taken ≥3 months apart. Patients with a baseline estimated glomerular filtration rate (eGFR) ≤60ml/min/1.73m2 were excluded. Chronic kidney disease was defined as two consecutive eGFR values ≤60ml/min/1.73m2 taken ≥3 months apart. Generalized estimating equations were used to identify factors associated with eGFR change. Competing risk regression adjusted for study site, age and sex, and cumulative_incidence plots were used to evaluate factors associated with CKD. Results: Of 2,547 patients eligible for this analysis, tenofovir was being used by 703 (27.6%) at baseline. Tenofovir use, high baseline eGFR, advanced HIV disease stage and low nadir CD4 were associated with a decrease in eGFR during follow up. CKD occurred at a rate of 3.4 per 1000 patient/years. Factors associated with CKD were tenofovir use, old age, low baseline eGFR, low nadir CD4, and protease inhibitor use. Conclusions: There is an urgent need to enhance renal monitoring and management capacity among at-risk groups in Asia and improve access to less nephrotoxic antiretrovirals.

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Síndrome de Fanconi y raquitismo hipofosfatémico asociado al uso de tenofovir en una niña infectada con VIH

Cited by 3 publications

References 20 publications

In vitro anti-HIV-1 activity of the bioactive compound extracted and purified from two different marine macroalgae (seaweeds) (Dictyota bartayesiana J.V.Lamouroux and Turbinaria decurrens Bory)

In vitro anti-HIV-1 activity of the bioactive compound extracted and purified from two different marine macroalgae (seaweeds) (Dictyota bartayesiana J.V.Lamouroux and Turbinaria decurrens Bory)

Neumonía a repetición en un paciente con deformidades óseas: a propósito de un caso de raquitismo

Changes in renal function with long‐term exposure to antiretroviral therapy in HIV‐infected adults in Asia

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