Síndrome de Guillain-Barré asociado a zika; análisis de la cohorte delegacional en la región Veracruz norte durante 2016-2017

Carpio-Orantes, Luis Del; Moguel, Karla Gabriela Peniche; Díaz, Jesús Salvador Sánchez; Pola-Ramírez, María del Rosario; Miranda, María del Pilar Mata; García-Méndez, Sergio; Perfecto-Arroyo, Miguel Arnulfo; Solís-Sánchez, Ishar; Trujillo-Ortega, B M; González-Flores, Encarnación

doi:10.1016/j.nrl.2018.05.002

Cited by 5 publications

(5 citation statements)

References 2 publications

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“…Traveller/non-traveller populations: In studies included in this update, we found additional evidence of GBS in both travellers and non-travellers with ZIKV infection. Ten publications report on 11 travellers 218, 220, 222– 224, 227, 229, 232– 234 , while 34 publications report GBS due to ZIKV in 402 non travellers 4, 44, 118, 219, 221, 225, 226, 228, 230, 231, 235– 237, 239– 247, 249, 251, 253– 260, 262, 263 .…”

Section: Resultsmentioning

confidence: 99%

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

et al. 2019

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Background: The Zika virus (ZIKV) caused a large outbreak in the Americas leading to the declaration of a Public Health Emergency of International Concern in February 2016. A causal relation between infection and adverse congenital outcomes such as microcephaly was declared by the World Health Organization (WHO) informed by a systematic review structured according to a framework of ten dimensions of causality, based on the work of Bradford Hill. Subsequently, the evidence has continued to accumulate, which we incorporate in regular updates of the original work, rendering it a living systematic review. Methods: We present an update of our living systematic review on the causal relation between ZIKV infection and adverse congenital outcomes and between ZIKV and GBS for four dimensions of causality: strength of association, dose-response, specificity, and consistency. We assess the evidence published between January 18, 2017 and July 1, 2019. Results: We found that the strength of association between ZIKV infection and adverse outcomes from case-control studies differs according to whether exposure to ZIKV is assessed in the mother (OR 3.8, 95% CI: 1.7-8.7, I2=19.8%) or the foetus/infant (OR 37.4, 95% CI: 11.0-127.1, I2=0%). In cohort studies, the risk of congenital abnormalities was 3.5 times higher after ZIKV infection (95% CI: 0.9-13.5, I2=0%). The strength of association between ZIKV infection and GBS was higher in studies that enrolled controls from hospital (OR: 55.8, 95% CI: 17.2-181.7, I2=0%) than in studies that enrolled controls at random from the same community or household (OR: 2.0, 95% CI: 0.8-5.4, I2=74.6%). In case-control studies, selection of controls from hospitals could have biased results. Conclusions: The conclusions that ZIKV infection causes adverse congenital outcomes and GBS are reinforced with the evidence published between January 18, 2017 and July 1, 2019.

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Section: Resultsmentioning

confidence: 99%

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

et al. 2019

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“…In one early study of a ZIKV-infection outbreak in Yap (Micronesia), it was estimated that 73% of the population over three years of age had been infected (in a population of around 10,000 people), and no cases of GBS were reported [22]. Lastly, in a recent study carried out in the Gulf Mexican state of Veracruz, Mexico, where 28 cases of GBS were described, only two (7.1%) had positive anti-ZIKV IgG and none had positive IgM or PCR in serum [23]. And, although there are numerous case control studies related to Zika virus infections and GBS, our study is unusual and particularly valuable because it highlights differences between symptomatic vs asymptomatic Zika virus infections as they relate to GBS, not just the relationship of Zika virus infection in general to GBS.…”

Section: Discussionmentioning

confidence: 99%

Zika Virus infection and Guillain-Barré syndrome in Northeastern Mexico: A case-control study

et al. 2020

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Background Beginning August 2017, we conducted a prospective case-control investigation in Monterrey, Mexico to assess the association between Zika virus (ZIKV) and Guillain-Barré syndrome (GBS). Methods For each of 50 GBS case-patients, we enrolled 2-3 afebrile controls (141 controls in total) matched by sex, age group, and presentation to same hospital within 7 days. Results PCR results for ZIKV in blood and/or urine were available on all subjects; serum ZIKV IgM antibody for 52% of case-patients and 80% of controls. Subjects were asked about antecedent illness in the two months prior to neurological onset (for case-patients) or interview (for controls). Laboratory evidence of ZIKV infection alone (PCR+ or IgM+) was not significantly different between case-patients and controls (OR: 1.26, 95% CI: 0.45-3.54) but antecedent symptomatic ZIKV infection [a typical ZIKV symptom (rash, joint pain, or conjunctivitis) plus

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“…Miller Fisher Syndrome (MFS) was reported in only four studies: one study from Singapore (five cases), [15] and three studies from Latin America (six cases). [14,18,32] ZIKV infection was confirmed in 118 (21%), probable in 128 (22%) and suspected in 324 (57%) of all cases with reported separate proportions of each ZIKV certainty level. In the overall pooled estimates of study populations with available proportions of at least the Brighton level 1 and a suspected ZIKV infection, 57% of cases had Not published as a case report but only one case fulfilling our criteria for suspected/probable/confirmed ZIKV in larger cohort of 418 cases.…”

Section: Patient Characteristicsmentioning

confidence: 96%

“…The first study was from French Polynesia in 2013-2014, [4] and the last was from Mexico in 2016-2017. [14] One study reported cases during and outside of a ZIKV outbreak period in Singapore [15] Inclusion criteria, case selection and setting differed between studies. A diagnosis of GBS was the inclusion criterion in 14 studies, and seven studies also included other acute neurologic illnesses besides GBS.…”

Section: Study Characteristics: Case Selection Case Ascertainment Anmentioning

confidence: 99%

“…Three studies only included patients admitted to the ICU, [17,22,28] and nine studies only included GBS patients with a clinical suspicion or laboratory evidence of a ZIKV infection. [14,17,[20][21][22][28][29][30][31] Seven studies were set in a specialized hospital (academic or reference centre), [4,16,18,23,26,31,32] and two multi-centre studies were set in both specialized and non-specialized hospitals. [21,28] These differences are potential sources of selection bias within studies and heterogeneity across studies.…”

Section: Study Characteristics: Case Selection Case Ascertainment Anmentioning

confidence: 99%

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Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype

et al. 2020

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Background The Zika virus (ZIKV) has been associated with Guillain-Barré syndrome (GBS) in epidemiological studies. Whether ZIKV-associated GBS is related to a specific clinical or electrophysiological phenotype has not been established. To this end, we performed a systematic review and meta-analysis of all published studies on ZIKV-related GBS. Methods We searched Pubmed, EMBASE and LILACS, and included all papers, reports or bulletins with full text in English, Spanish or Portuguese, reporting original data of patients with GBS and a suspected, probable or confirmed recent ZIKV infection. Data were extracted according to a predefined protocol, and pooled proportions were calculated. Results Thirty-five studies were included (13 single case reports and 22 case series, case-control or cohort studies), reporting on a total of 601 GBS patients with a suspected, probable or confirmed ZIKV infection. Data from 21 studies and 587 cases were available to be summarized. ZIKV infection was confirmed in 21%, probable in 22% and suspected in 57% of cases. ZIKV PCR was positive in 30% (95%CI 15-47) of tested patients. The most common clinical features were: limb weakness 97% (95%CI 93-99), diminished/absent reflexes 96% (95%CI 88-100), sensory symptoms 82% (95%CI 76-88), and facial palsy 51% (95%CI 44-58). Median time between infectious and neurological symptoms was 5-12 days. Most PLOS NEGLECTED TROPICAL DISEASES

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Síndrome de Guillain-Barré asociado a zika; análisis de la cohorte delegacional en la región Veracruz norte durante 2016-2017

Cited by 5 publications

References 2 publications

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

Zika virus infection as a cause of congenital brain abnormalities and Guillain-Barré syndrome: A living systematic review

Zika Virus infection and Guillain-Barré syndrome in Northeastern Mexico: A case-control study

Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype

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