Síndromes hormonales paraneoplásicos

Forga, Lluís; Anda, Emma; Esteban, Juan Pablo Martínez de

doi:10.4321/s1137-66272005000300006

Cited by 9 publications

(4 citation statements)

References 25 publications

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“…These include serum cortisol levels, plasma ACTH, and high-dose dexamethasone suppression test (HDDST) which has better sensitivity [10]. Radiological evaluation includes ultrasonography, computed tomography (CT) scan of abdomen, and MRI of the brain.…”

Section: Discussionmentioning

confidence: 99%

Endogenous Cushing’s Syndrome with Precocious Puberty in an 8-Year-Old Boy due to a Large Unilateral Adrenal Adenoma

Hossain

Alam

Nabi

et al. 2013

Case Reports in Endocrinology

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Adrenocortical tumors (ACTs) causing Cushing's syndrome are extremely rare in children and adolescents. Bilateral macronodular adrenocortical disease which is a component of the McCune-Albright syndrome is the most common cause of endogenous Cushing's syndrome. We report the case of a boy with Cushing's syndrome who presented with obesity and growth retardation. The child was hypertensive. The biochemical evaluation revealed that his serum cortisol levels were 25.80 μg/dL, with a concomitant plasma ACTH level of 10.0 pg/mL and nonsuppressed serum cortisol on high-dose dexamethasone suppression test (HDDST) to be 20.38 μg/dL. Computed tomography of the abdomen demonstrated a 8 × 6 × 5 cm left adrenal mass with internal calcifications. Following preoperative stabilization, laparotomy was carried out which revealed a lobulated left adrenal mass with intact capsule weighing 120 grams. Histopathological examination revealed a benign cortical neoplastic lesion, suggestive of adrenal adenoma; composed of large polygonal cells with centrally placed nuclei and prominent nucleoli without capsular and vascular invasion. On the seventh postoperative day, cortisol levels were within normal range indicating biochemical remission of Cushing's syndrome. On followup after three months, the patient showed significant clinical improvement and had lost moderate amount of weight and adrenal imaging was found to be normal.

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Section: Discussionmentioning

confidence: 99%

Endogenous Cushing’s Syndrome with Precocious Puberty in an 8-Year-Old Boy due to a Large Unilateral Adrenal Adenoma

Hossain

Alam

Nabi

et al. 2013

Case Reports in Endocrinology

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“…Estos tumores pueden ser de origen mesodérmico (mesoteliomas, fibrosarcomas, leiomiosarcomas) epitelial o hematopoyético (linfoma gastrointestinal, leucemias). La hipoglicemia que producen es de ayuno y se deben al bloqueo de la producción hepática de glucosa debido a la inhibición de la glucogenolisis y gluconeogénesis, bloqueo de la lipolisis en el tejido adiposo, lo que conlleva niveles séricos bajos de ácidos grasos libres y aumento del consumo periférico de glucosa debido tanto a un aumento del consumo de glucosa por el tumor como a un incremento de la captación periférica de glucosa por el músculo esquelético (24) .…”

Section: Referencias Bibliográficasunclassified

Dermatomiositis y síndrome de Evans asociado a infección por HTLV-1

Loja-Oropeza¹,

Zavala-Flores

Vilca-Vásquez

2016

Rev Peru Med Exp Salud Publica

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Paciente mujer de 55 años de edad, natural de Ayacucho, con antecedente de dermatomiositis desde hace 3 años, recibió tratamiento irregular con prednisona. Dos meses antes del ingreso presenta anemia hemolítica autoinmune y púrpura trombocitopénica idiopática, recibió pulsos de metilprednisolona y transfusión de paquetes globulares. Al ingreso, soporosa, mal estado general, marcada pérdida ponderal, deshidratada, livedo reticularis en miembros inferiores, onicodistrofia y onicolisis múltiple en los dedos de ambos pies. Western Blot positivo para HTLV-1. Evoluciona con hipoglicemia recurrente. Reportamos un caso de dermatomiositis y síndrome de Evans presentados en el contexto de una infección por virus linfotrópico humano tipo 1. Palabras clave: Anemia hemolítica autoinmune; Dermatomiositis; Virus 1 linfotropico T humano (fuente: DeCS-BIREME). DERMATOMIOSITIS AND EVANS SYNDROME ASSOCIATED WITH HTLV-1 INFECTIONA 55-year-old female patient, born in Ayacucho, with a history of dermatomyositis for 3 years, who received irregular treatment with prednisone. Two months prior to admission, she presented with autoinmune hemolytic anemia and idiopathic thrombocytopenic purpura. The patient received methylprednisolone pulse therapy and packed red blood cells transfusions. Upon admission, she was drowsy, with a poor overall status, marked weight loss, dehydration, with presence of livedo reticularis in her lower extremities, and onychodystrophy and onycholysis on the toes of both feet. Western blot test was positive for human T-lymphotropic virus type 1 (HTLV-1). The patient evolved with recurrent hypoglycemia. Therefore, we report a case of dermatomyositis and Evans syndrome in the context of an HTLV-1 infection. Key words: Anemia, hemolytic, autoimmune; Dermatomyositis; Human T-lymphotropic virus 1 (source: MeSH NLM). INTRODUCCIÓNLa infección por el virus linfotrópico humano (HTLV-1) es una enfermedad emergente en Latinoamérica. Es endémica en países como Brasil, Colombia, Perú y afecta principalmente a poblaciones quechuas, afroamericanos y descendientes de japoneses, alcanzando una prevalencia global de 0,5-5%. En el Perú, la prevalencia varía entre 1,3 a 3,8%, considerándose una infección endémica. La transmisión de HTLV-1 ocurre a través de tres vías: sexual, de madre a niño (sobre todo a través de lactancia materna) y por transfusión de sangre (1,2) .Entre las formas clínicas relacionadas a la infección por HTLV-1 existen tres grupos más o menos bien definidos que incluyen en el primer grupo a enfermedades con manifestaciones inflamatorias como el síndrome de Sjögren, tiroiditis, alveolitis, nefritis intersticial, uveítis, polimiositis-dermatomiositis (PM-DM) y la paraparesia espástica tropical. Un segundo grupo contempla neoplasias como la leucemia de células T del adulto y el linfoma cutáneo. En el tercer grupo se consideran a las infecciones como la sarna noruega, la dermatitis infectiva, la onicomicosis múltiple, la tuberculosis, la hiperinfestación por Strongyloides stercolaris, la lepra y la paracoccidiodomicos...

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“…En 1941, Fuller Albright, considerado el padre de la endocrinología moderna, propuso la idea de que los tumores pueden causar síndromes endocrinos secretando hormonas de forma inapropiada. GW Liddle, en 1969 acuñó el término "síndrome hormonal ectópico" para referirse a este tipo de situaciones 1 .…”

Section: Introductionunclassified

Acromegalia ectópica por carcinoide bronquial

Álvaro

Arribas

Apiñániz

et al. 2013

Anales Sis San Navarra

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Tumours that cause ectopic acromegaly can do so through the secretion of GH or GHRH. One hundred cases of ectopic acromegaly due to secretion of GHRH have been described. Given the rarity of this pathology, we present a clinical case with the aim of contributing our diagnostic-therapeutic experience and the subsequent follow-up. We present the case of a patient with acromegaloid physical features that had evolved over several years. Concomitantly, he also presented other accompanying symptoms that were suggestive of a possible bronchial origin. Facing the clinical suspicion of acromegaly, we opted to confirm it biochemically and subsequently through image study. A hypophysary origin was ruled out, so we carried out screening for a bronchial neuroendocrine and/or gastrointestinal tumor as they are the most frequent localizations. The treatment of choice was surgical resection.

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Síndromes hormonales paraneoplásicos

Cited by 9 publications

References 25 publications

Endogenous Cushing’s Syndrome with Precocious Puberty in an 8-Year-Old Boy due to a Large Unilateral Adrenal Adenoma

Endogenous Cushing’s Syndrome with Precocious Puberty in an 8-Year-Old Boy due to a Large Unilateral Adrenal Adenoma

Dermatomiositis y síndrome de Evans asociado a infección por HTLV-1

Acromegalia ectópica por carcinoide bronquial

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