Single 30 min treadmill exercise session suppresses the production of pro-inflammatory cytokines and oxidative stress in obese female adolescents

Abstract

Objectives Regular treadmill exercise may result in changes in pro-inflammatory cytokines and oxidative stress. However, the way acute treadmill exercise mechanisms affect the changes in pro-inflammatory cytokines and oxidative stress in obese has not been comprehensively exposed. This study aimed to analyze the pro-inflammatory cytokines and oxidative stress between 30 min before treadmill exercise and 24 h after treadmill exercise in obese adolescents. Methods A total of 20 obese females aged 19–24 years were recruited from female students and given one session of treadmill exercise with an intensity of 60–70% HRmax. Thiobarbituric acid reactive substance (TBARS) was used to analyze serum levels of MDA, while enzyme-linked immunosorbent assay (ELISA) was used to analyze serum levels of TNF-α and IL-6. Moreover, the independent samples t-test with a significance level of 5% was employed to have the statistical analysis. Results The results on 24 h after treadmill exercise and delta (Δ) between CTRL and TREG showed a significant difference (p<0.001). Conclusions This study found a decrease in pro-inflammatory cytokines and oxidative stress 24 h after treadmill exercise in obese adolescents. Therefore, treadmill exercise can be a promising strategy for preventing adolescents from obesity as well as preventing disease risks associated with oxidative stress and chronic inflammation.

Impact of Time-Resricted Feeding and Aerobic Exercise Combination on Promotes Myokine Levels and Improve Body Composition in Obese Women

“…Body composition was measured during the pre-test and post-test using the TANITA Body Composition Analyzer DC3607601(2)-1604 FA (TANITA Corporation of America, Inc., Arlington Heights, IL, USA) (Pranoto et al, 2023). The data collected was body fat percentage (PBF), fat mass and muscle mass and BMI.…”

Moderate-intensity endurance training has higher effects suppression of oxidative stress secretion than strength training in obese students

“…Numerous studies have indicated that physical exercise can lead to an elevation in Malondialdehyde (MDA) levels, serving as a marker of oxidative stress (Diaba-Nuhoho et al, 2018;Park & Kwak, 2016;Bhutia et al, 2011). Conversely, other studies demonstrate a notable decrease in MDA levels following exercise (Pranoto et al, 2023;Wang et al, 2023;Lu et al, 2021b), thereby confirming the existing ambiguity surrounding this issue, potentially due to the complexity of adaptive mechanisms during physical exercise. Consequently, this study seeks to validate the impact of moderate-intensity endurance training and strength training on the reduction of oxidative stress in students with obesity.…”

Treadmill has a more beneficial effect than cycling on fat loss through myokines secretion in obese women

“…However, the results of a study by Salamat et al (2016) reported that moderateintensity treadmill exercise decreased IL-6 levels. Research by Pranoto et al (2023b) reported that IL-6 levels decreased after 24 hours of moderate-intensity treadmill exercise in obese women. However, the effect of exercise models in obesity on irisin and IL-6 parameters has not been investigated.…”

“…Exercise is considered one of the effective and efficient methods to prevent the increasing prevalence of obesity (Rejeki et al, 2021;Pranoto et al, 2023b;Merawati et al, 2023), through the mediation of irisin in the process of increasing energy expenditure, glucose, and lipid metabolism (Perakakis et al, 2017). The increase in irisin levels during exercise is a result of increased muscle contraction, which activates peroxisome proliferatoractivated receptor gamma coactivator-1-alpha (PGC1-α) to stimulate fibronectin type III domain-containing protein 5 (FNDC5) secretion and proteolytic cleavage of FNDC-5 membrane protein in skeletal muscle, resulting in the release of irisin into the bloodstream (Costello et al, 2018;Rejeki et al, 2021).…”