Single 808 nm near‐infrared‐triggered multifunctional upconverting phototheranostic nanocomposite for imaging‐guided high‐efficiency treatment of tumors

Abstract

Multifunctional phototheranostic nanocomposites are promising for early diagnosis and precision therapy of cancer. Aim to enhance their accuracy and efficiency, in this study, we develop a single-laser excited activatable phototheranostic nanocomposite (UCNPs-D-MQ): 808 nm-excited upconverting nanoparticles (UCNPs) as the matrix programmed assembly with amphipathic compound DSPE-PEG-COOH, a near-infrared absorbing polymer DPP and the pro-photosensitizer MBQB. Upon endocytosed by cancer cells and excited by the 808 nm laser, UCNPs-D-MQ could produce high-yield reactive oxygen species (ROS) as the results of singlet oxygen generation from transferring to methylene blue, GSH depletion and ROS generation from photoactivation. It was proven both in vitro and in vivo that the nanocomposites exhibits remarkable therapeutic efficacy as well as minimal photodamage to normal cells. These results reveal UCNPs-D-MQ as a robust theranostic agent for tumor phototherapy.

VHPKQHR Peptide Modified Ultrasmall Paramagnetic Iron Oxide Nanoparticles Targeting Rheumatoid Arthritis for T1-Weighted Magnetic Resonance Imaging

“…Zeta potential and dynamic light scattering (DLS) measurements were conducted using a Malvern Zetasizer Nano ZS (Malvern Instruments) ( Li et al, 2020 ). The morphology and size of USPIO and UVHP were characterized by a field emission 2100F transmission electron microscope (TEM; JEOL, Japan) under 200-kV acceleration voltage ( Yang et al, 2021 ). One-tesla MRI scanner (NM42-040H-I, Niumag, China) was used to measure the r 1 and r 2 values of USPIO and UVHP.…”

Study on combination therapy for lung cancer through pemetrexed‐loaded mesoporous polydopamine nanoparticles

“…Moreover, PDA has strong absorbance in the near‐infrared (NIR) region. Some researchers have proved that PDA has excellent photothermal conversion under the irradiation of 808 nm laser 19,20 . Furthermore, although PDA could scavenge ROS, it could promote the generation of ROS after exposing in NIR light 21,22 .…”

“…Some researchers have proved that PDA has excellent photothermal conversion under the irradiation of 808 nm laser. 19 , 20 Furthermore, although PDA could scavenge ROS, it could promote the generation of ROS after exposing in NIR light. 21 , 22 However, the limited surface area of PDA nanoparticles limits their application in loading drugs.…”