Single and mixture toxicity evaluation of three phenolic compounds to the terrestrial ecosystem

Oliveira, Ketelen Michele Guilherme de; Carvalho, Endrew Henrique de Sousa; Filho, Ronaldo dos Santos Falcão; Sivek, Tainá Wilke; Thá, Emanoela Lundgren; Souza, Irisdoris Rodrigues de; Coelho, Lauren Dalat de Sousa; Pimenta, Maria Eunice Bertelli; Oliveira, Gisele Augusto Rodrigues de; Oliveira, Danielle Palma de; Cestari, Marta Margarete; Leme, Daniela Morais

doi:10.1016/j.jenvman.2021.113226

Cited by 28 publications

(5 citation statements)

References 55 publications

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“…1 Three studies showed that BPA significantly increased chromosomal aberrations in plants. [127][128][129] Two studies showed that BPA induced microtubule abnormalities in acellular systems. 130,131 Figure 2.…”

Section: Mechanistic Data For Bpa Organized By Kcs Of Carcinogensmentioning

confidence: 99%

Application of the Key Characteristics of Carcinogens to Bisphenol A

Ricker,

Cheng,

Hsieh

et al. 2024

Int J Toxicol

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The ten key characteristics (KCs) of carcinogens are based on characteristics of known human carcinogens and encompass many types of endpoints. We propose that an objective review of the large amount of cancer mechanistic evidence for the chemical bisphenol A (BPA) can be achieved through use of these KCs. A search on metabolic and mechanistic data relevant to the carcinogenicity of BPA was conducted and web-based software tools were used to screen and organize the results. We applied the KCs to systematically identify, organize, and summarize mechanistic information for BPA, and to bring relevant carcinogenic mechanisms into focus. For some KCs with very large data sets, we utilized reviews focused on specific endpoints. Over 3000 studies for BPA from various data streams (exposed humans, animals, in vitro and cell-free systems) were identified. Mechanistic data relevant to each of the ten KCs were identified, with receptor-mediated effects, epigenetic alterations, oxidative stress, and cell proliferation being especially data rich. Reactive and bioactive metabolites are also associated with a number of KCs. This review demonstrates how the KCs can be applied to evaluate mechanistic data, especially for data-rich chemicals. While individual entities may have different approaches for the incorporation of mechanistic data in cancer hazard identification, the KCs provide a practical framework for conducting an objective examination of the available mechanistic data without a priori assumptions on mode of action. This analysis of the mechanistic data available for BPA suggests multiple and inter-connected mechanisms through which this chemical can act.

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Section: Mechanistic Data For Bpa Organized By Kcs Of Carcinogensmentioning

confidence: 99%

Application of the Key Characteristics of Carcinogens to Bisphenol A

Ricker,

Cheng,

Hsieh

et al. 2024

Int J Toxicol

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“…1,2 However, its improper use can harm human health. 3 In particular, its absorption by the body can cause dermatitis, methemoglobinosis, and asthma. Therefore, developing a method for the rapid and accurate detection of o -AP is necessary.…”

Section: Introductionmentioning

confidence: 99%

Visible-light-driven photoelectrochemical sensor based on conjugated microporous polymer-grafted graphene for o-aminophenol detection

Qin,

Xiang,

et al. 2024

Anal. Methods

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“…The primary factor influencing phenol toxicity is its reactivity with biomolecules within a cell, particularly its capacity to provide free electrons to oxidized substrates. Catalyzed by oxidative enzymes found in different organs such prostaglandins, myeloperoxidases, and peroxidases (de Oliveira et al, 2021). When phenol is consumed, it can cause central nervous system (CNS) abnormalities that can result in collapse and coma (Chae et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Phenol Metabolizing Bacillus Cereus Strain Sbbp4

Saboor Muarij Bunny,

Muccee,

Muhammad Khurshid

et al. 2023

JMMG

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US Environment Protection Agency has categorized phenol and its derivatives as persistent organic pollutants (POPs) due to the associated deleterious effects. Conventional mitigation approaches due to the complex procedures, high cost and involvement of lots of man power have failed in clearing this pollutant from ecosystem. Bioremediation based on bacteria can replace these conventional approaches due to simpler technology and low cost. In present study, we have tried to isolate and characterize phenol metabolizing bacteria from tannery industry soil. Isolation was carried out using minimal salt media (MSM) and serial dilution method. Followed this, bacterium was analyzed via growth curve analysis, ribotyping, biochemical testing, antibiotic sensitivity profiling, phenol removal assay and FTIR analysis. Bacterium was identified to be Bacillus cereus. It was fast growing capable of removing 98.7% phenol. It exhibited resistance against amoxicillin, augmentin, cefadroxil, and cephalexin. Comparison of FTIR spectra of control vs bacterial sample also showed slight variation in peaks indicating the change in bonds of phenol in the presence of present study isolate. Bacterium Bacillus cereus strain SBBP4 can be investigated for further optimization and employed for efficient phenol removal.

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Single and mixture toxicity evaluation of three phenolic compounds to the terrestrial ecosystem

Cited by 28 publications

References 55 publications

Application of the Key Characteristics of Carcinogens to Bisphenol A

Application of the Key Characteristics of Carcinogens to Bisphenol A

Visible-light-driven photoelectrochemical sensor based on conjugated microporous polymer-grafted graphene for o-aminophenol detection

Isolation and Characterization of Phenol Metabolizing Bacillus Cereus Strain Sbbp4

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