Single‐Atom Nanozyme Based on Nanoengineered Fe–N–C Catalyst with Superior Peroxidase‐Like Activity for Ultrasensitive Bioassays

Cheng, Nan; Li, Jincheng; Liu, Dong; Lin, Yuehe; Du, Dan

doi:10.1002/smll.201901485

Cited by 234 publications

(177 citation statements)

References 39 publications

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“…Chemie using as eries of paper-based bioassays ( Figure 3E). [83] The turnover number of FeÀNÀCSAzyme was 4500 times higher than that of the classical Fe 3 O 4 nanozyme.…”

Section: Methodsmentioning

confidence: 94%

When Nanozymes Meet Single‐Atom Catalysis

et al. 2019

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Nanomaterials with enzyme‐like activities, coined nanozymes, have been researched widely as they offer unparalleled advantages in terms of low cost, superior activity, and high stability. The complex structure and composition of nanozymes has led to extensive investigation of their catalytic sites at an atomic scale, and to an in‐depth understanding of the biocatalysis occurring. Single‐atom catalysts (SACs), characterized by atomically dispersed active sites, have provided opportunities for mimicking metalloprotease and for bridging the gap between natural enzymes and nanozymes. In this Minireview, we illustrate the unique properties of nanozymes and we discuss recent advances in the synthesis, characterization, and applications of SACs. Subsequently, we outline the impressive progress made in single‐atom nanozymes and we discuss their applications in sensing, degradation of organic pollutants, and in therapeutic roles. Finally, we present the major challenges and opportunities remaining for a successful marriage of nanozymes and SACs.

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“…Chemie using as eries of paper-based bioassays ( Figure 3E). [83] The turnover number of FeÀNÀCSAzyme was 4500 times higher than that of the classical Fe 3 O 4 nanozyme.…”

Section: Methodsmentioning

confidence: 94%

When Nanozymes Meet Single‐Atom Catalysis

et al. 2019

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“…Mater. 2020, 32,1905994 CNT/FeNC Fe Carbon nanotubes Peroxidase-mimicking Biosensing [87] Fe-N-C SAN Fe Porous carbon Peroxidase-mimicking Biosensing [88] Fe-SAs/NC Fe N-doped porous carbon SOD-and CAT-mimicking Oxidative stress cytoprotection [46] www.advmat.de www.advancedsciencenews.com surrounding environment. Therefore, exploring new and efficient in situ characterization techniques and computational modeling approaches are highly urgent to identify the reaction intermediates and thus comprehend probable catalytic kinetics and mechanism of SACs in the catalytic processes for biomedical use.…”

Section: Discussionmentioning

confidence: 99%

“…Based on the superior catalytic characteristics and maximum atomic utilization, a single‐Fe‐atom catalyst was engineered via anchoring Fe atoms on carbon nanotube modifying with N‐doped carbon (CNT/FeNC), leading to 100% single Fe atoms dispersion and high surface area of 1140 m 2 g −1 ( Figure a) . The CNT/FeNC exhibited prominent peroxidase‐mimicking activity in catalyzing the H 2 O 2 into •OH in acid media with turnover number (TON) of 135 cycles in 5 min, which was approximately 4500 times higher than that of conventional Fe 3 O 4 nanozyme.…”

Section: Biomedical Applications Of Sacsmentioning

confidence: 99%

Single‐Atom Catalysts in Catalytic Biomedicine

2020

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The intrinsic deficiencies of nanoparticle‐initiated catalysis for biomedical applications promote the fast development of alternative versatile theranostic modalities. The catalytic performance and selectivity are the critical issues that are challenging to be augmented and optimized in biological conditions. Single‐atom catalysts (SACs) featuring atomically dispersed single metal atoms have emerged as one of the most explored catalysts in biomedicine recently due to their preeminent catalytic activity and superior selectivity distinct from their nanosized counterparts. Herein, an overview of the pivotal significance of SACs and some underlying critical issues that need to be addressed is provided, with a specific focus on their versatile biomedical applications. Their fabrication strategies, surface engineering, and structural characterizations are discussed briefly. In particular, the catalytic performance of SACs in triggering some representative catalytic reactions for providing the fundamentals of biomedical use is discussed. A sequence of representative paradigms is summarized on the successful construction of SACs for varied biomedical applications (e.g., cancer treatment, wound disinfection, biosensing, and oxidative‐stress cytoprotection) with an emphasis on uncovering the intrinsic catalytic mechanisms and understanding the underlying structure–performance relationships. Finally, opportunities and challenges faced in the future development of SACs‐triggered catalysis for biomedical use are discussed and outlooked.

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“…Atomically dispersed catalysts have attracted ever‐increasing attention in a variety of reactions due to the high atom utilization and controllable coordination environment . In electrochemistry, atomically dispersed transition metal atom coordinated with nitrogen in carbon‐based (M‐N‐C) materials are particularly appealing, because the isolated M‐N‐C centers have been proven to be the highly active sites in various electrochemical reactions, especially in oxygen reduction reaction (ORR) .…”

Section: Introductionmentioning

confidence: 99%

“…DOI: 10.1002/smll.201905920 utilization and controllable coordination environment. [1][2][3][4][5][6][7][8][9] In electrochemistry, atomically dispersed transition metal atom coordinated with nitrogen in carbonbased (M-N-C) materials are particularly appealing, because the isolated M-N-C centers have been proven to be the highly active sites in various electrochemical reactions, especially in oxygen reduction reaction (ORR). [10][11][12][13][14][15][16] Despite the outstanding activity and selectivity of M-N-C single atoms, the high surface energy of single atoms brings about the challenges in the chemical synthesis.…”

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confidence: 99%

Boosting the Loading of Metal Single Atoms via a Bioconcentration Strategy

Lei

Liu

Yin

et al. 2020

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Increasing the mass loading of transition metal single atoms coordinated with nitrogen in carbon‐based materials (M‐N‐C) is still challenging. Herein, inspired by the bioconcentration effect in the living body, a biochemistry strategy for the synthesis of Fe‐N‐C single atoms is demonstrated. Through introducing ferrous glycinate into the growth of fungus, the Fe atoms are bioconcentrated in hyphae. The highly dispersed Fe‐N‐C single atoms in hyphae‐derived carbon fibers (labeled as Fe‐N‐C SA/HCF) are prepared by the pyrolysis of Fe‐riched hyphae. In the bioconcentration process, the uptake of Fe ions by hyphae promotes the secretion of glutathione and ferritin, which provides additional coordination sites for Fe ions. Accordingly, the mass content of Fe in bioconcentrated Fe‐N‐C SA/HCF reaches 4.8%, which is 5.3 times larger than that of the sample prepared by the conventional pyrolysis process. The present bioconcentration strategy is further extended to the preparation of Co, Ni, and Mn single atoms. Owing to the high content of Fe‐N‐C single atoms, Fe‐N‐C SA/HCF shows the onset potential (Eonset) of 0.931 V versus reversible hydrogen electrode (RHE) and half‐wave potential (E1/2) of 0.802 V versus RHE in oxygen reduction reaction measurements, which is comparable to the commercial Pt/C catalysts.

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Single‐Atom Nanozyme Based on Nanoengineered Fe–N–C Catalyst with Superior Peroxidase‐Like Activity for Ultrasensitive Bioassays

Cited by 234 publications

References 39 publications

When Nanozymes Meet Single‐Atom Catalysis

When Nanozymes Meet Single‐Atom Catalysis

Single‐Atom Catalysts in Catalytic Biomedicine

Boosting the Loading of Metal Single Atoms via a Bioconcentration Strategy

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