Single-atom nanozymes as promising catalysts for biosensing and biomedical applications

Xiao, Yaqian; Hu, Xiao; Liu, Qiming; Zhang, Yulin; Zhang, Guojun; Chen, Shaowei

doi:10.1039/d3qi00430a

Cited by 16 publications

(7 citation statements)

References 211 publications

(252 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…31,34,35 In the same year, a SAC that consisted of isolated single Pt atoms anchored to FeO x was synthesized by Zhang et al 36 This catalyst has extremely high atom-efficiency, exhibiting excellent stability and high activity for CO oxidation and attracting extensive research interests. 36 After that, numerous SACs, [37][38][39][40][41][42][43][44][45][46] including non-noble metal and multiple-metal SACs, [47][48][49][50][51][52][53][54][55][56] have been developed as excellent catalysts with special catalytic properties for application in photocatalysis, [57][58][59][60] electrocatalysis, [61][62][63][64][65][66] and thermocatalysis [67][68][69][70][71][72][73][74][75][76] (Fig. 1).…”

Section: Lili Hanmentioning

confidence: 99%

Local structural environment of single-atom catalysts

Chen,

Han

2024

Inorg. Chem. Front.

View full text Add to dashboard Cite

show abstract

Section: Lili Hanmentioning

confidence: 99%

Local structural environment of single-atom catalysts

Chen,

Han

2024

Inorg. Chem. Front.

View full text Add to dashboard Cite

show abstract

“…Satisfactorily, nanozymes with POD-like activity have sufficient ability to convert H 2 O 2 to •OH and deplete ROS at the wound site. 107 Meanwhile, the large amount of highly toxic •OH can effectively induce the death of infectious pathogens while reducing inflammatory responses, ultimately promoting DFU healing. For example, Wen et al 108 designed a multifunctional nanozyme based on cerium oxide nanoparticles supported on black phosphorus (BP) nanosheets, where the excellent POD activity was ascribed to the high ratio of Ce 3+ to Ce 4+ when the particle diameter was reduced to the nanoscale.…”

Section: Pod-like Activity Ros Mainly Hydrogen Peroxide Superoxide An...mentioning

confidence: 99%

“…High levels of ROS disrupt the activity of biomolecules, leading to excessive oxidative stress. Satisfactorily, nanozymes with POD-like activity have sufficient ability to convert H 2 O 2 to •OH and deplete ROS at the wound site . Meanwhile, the large amount of highly toxic •OH can effectively induce the death of infectious pathogens while reducing inflammatory responses, ultimately promoting DFU healing.…”

Section: Mechanisms Of Nanozymes For Dfu Treatmentmentioning

confidence: 99%

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Xiao,

Zhao,

DuBois

et al. 2024

ACS Biomater. Sci. Eng.

Self Cite

View full text Add to dashboard Cite

Diabetic foot ulcers (DFU) are chronic, refractory wounds caused by diabetic neuropathy, vascular disease, and bacterial infection, and have become one of the most serious and persistent complications of diabetes mellitus because of their high incidence and difficulty in healing. Its malignancy results from a complex microenvironment that includes a series of unfriendly physiological states secondary to hyperglycemia, such as recurrent infections, excessive oxidative stress, persistent inflammation, and ischemia and hypoxia. However, current common clinical treatments, such as antibiotic therapy, insulin therapy, surgical debridement, and conventional wound dressings all have drawbacks, and suboptimal outcomes exacerbate the financial and physical burdens of diabetic patients. Therefore, development of new, effective and affordable treatments for DFU represents a top priority to improve the quality of life of diabetic patients. In recent years, nanozymes-based diabetic wound therapy systems have been attracting extensive interest by integrating the unique advantages of nanomaterials and natural enzymes. Compared with natural enzymes, nanozymes possess more stable catalytic activity, lower production cost and greater maneuverability. Remarkably, many nanozymes possess multienzyme activities that can cascade multiple enzymecatalyzed reactions simultaneously throughout the recovery process of DFU. Additionally, their favorable photothermal-acoustic properties can be exploited for further enhancement of the therapeutic effects. In this review we first describe the characteristic pathological microenvironment of DFU, then discuss the therapeutic mechanisms and applications of nanozymes in DFU healing, and finally, highlight the challenges and perspectives of nanozyme development for DFU treatment.

show abstract

“…The antibacterial activity of SAzymes is mainly achieved by their generation of ROS such as •OH and •O 2 − [33]. The generated ROS can destroy the cell membrane and damage the biomolecules in the microbial cell, such as DNA, proteins, and lipids, which leads to the death of bacteria without inducing drug resistance [56].…”

Section: Enzymatic Therapymentioning

confidence: 99%

“…Benefiting from these merits, SAzymes have achieved remarkable progress in multiple biomedical applications, including cancer therapy, antibacterial therapy, antioxidation therapy, and biosensing, in recent years. Several excellent reviews have summarized all these applications but did so without a thorough discussion of the antibacterial application [28][29][30][31][32][33][34][35]. In this review, we focus on the latest advances in SAzymes for antibacterial applications, with specific attention paid to their action mechanism (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

Burgeoning Single-Atom Nanozymes for Efficient Bacterial Elimination

Shi,

Cui,

Yuan

et al. 2023

Nanomaterials

View full text Add to dashboard Cite

To fight against antibacterial-resistant bacteria-induced infections, the development of highly efficient antibacterial agents with a low risk of inducing resistance is exceedingly urgent. Nanozymes can rapidly kill bacteria with high efficiency by generating reactive oxygen species via enzyme-mimetic catalytic reactions, making them promising alternatives to antibiotics for antibacterial applications. However, insufficient catalytic activity greatly limits the development of nanozymes to eliminate bacterial infection. By increasing atom utilization to the maximum, single-atom nanozymes (SAzymes) with an atomical dispersion of active metal sites manifest superior enzyme-like activities and have achieved great results in antibacterial applications in recent years. In this review, the latest advances in antibacterial SAzymes are summarized, with specific attention to the action mechanism involved in antibacterial applications covering wound disinfection, osteomyelitis treatment, and marine antibiofouling. The remaining challenges and further perspectives of SAzymes for practical antibacterial applications are also discussed.

show abstract

Single-atom nanozymes as promising catalysts for biosensing and biomedical applications

Abstract: Nanozymes with intrinsic enzyme-like properties and excellent stability are promising alternatives to natural enzymes. Yet, the low density of active sites and unclear crystal structure has been the major obstacles...

Cited by 16 publications

References 211 publications

Local structural environment of single-atom catalysts

Local structural environment of single-atom catalysts

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Burgeoning Single-Atom Nanozymes for Efficient Bacterial Elimination

Contact Info

Product

Resources

About