Single breath transfer factor for carbon monoxide in an asymptomatic population of never smokers.

Gulsvik, Amund; Bakke, Per; Humerfelt, Sjur; Omenaas, Ernst; Tosteson, Tor D.; Weiss, Scott T.; Speizer, Frank E.

doi:10.1136/thx.47.3.167

Cited by 35 publications

(35 citation statements)

References 19 publications

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“…Static lung volumes, CV and L\-N z were measured for 18 deep divers only, before and one year after the deep dive. For FVC, FEVl.O' FEF z5 _ 75 ' and Tl co' the predicted values of Gulsvik (13) and Guls vik et al (14) were used ; these value s are based on cros s-sectional surveys of asymptomatic subjects in a general population. For FEF 75 _ 85 , FEF 50 , and FEF 75 the predi cted values were taken from our previous study of divers ' Scand J Work Environ Health 1993. vol 19, no 2 lung function, which included a matched reference group (4), as updated predicted values for the general Scandinavian population are not available.…”

Section: Methodsmentioning

confidence: 99%

Pulmonary function one and four years after a deep saturation dive.

Thorsen

Segadal²,

Kambestad³

et al. 1993

Scand J Work Environ Health

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. Pulmonary function one and four years after a deep saturation dive. Scand J Work Environ Health 1993;19:115-20. The pulmonary function of 24 Norwegian divers who had participated in a deep saturation dive to pressures of 3. 1-4.6 MPa was reevaluated one and four years later. Twenty-eight divers performing ordinary saturation diving to pressures of 0.8-1.6 MPa and followed over a three-year period served as referents. A significant reduction in forced expiratory volume in 1 s (FEY,,) of 210 (SD 84) ml (P< O.OOI) occurred the first year after the dive. Thereafter the annual reduction in FEY, 0 was 28 (SD 62) ml . year'; this value did not differ from the 35 (SD 80) ml . year" of the referents. The forced midexpiratory flow rate and forced expiratory flow rates at low lung volumes were also significantly reduced one year after the deep dive, and the closing volume was increased. No significant changes occurred in forced vital capacity. The results agree with those of cross-sectional studies on divers' lung function and indicate the development of airflow limitation in relation to diving exposure.Key terms: diving, lung function, occupational exposure.Divin g operations are necessary fo r the installation and maintenance of the oil and gas production and tran sport systems in the North Sea at depths of 50-360 m, corresponding to pressures of 0.6-3.7 MPa .

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Section: Methodsmentioning

confidence: 99%

Pulmonary function one and four years after a deep saturation dive.

Thorsen

Segadal²,

Kambestad³

et al. 1993

Scand J Work Environ Health

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“…Table 1 also shows considerable betweenstudy differences both in mean values and in the age and height coefficients, as is found for most other predicted values for tests of lung function [6]. From first principles, a dependence on height would not be expected, but it has been suggested [16] that in taller people the apices of the lungs may be more poorly perfused relative to the mid and lower zones for gravitational reasons; the resulting inhomogeneity in blood flow and blood volume would reduce the measured KCO. All published data on changes with age are derived from cross-sectional studies.…”

mentioning

confidence: 98%

Carbon monoxide transfer coefficient (transfer factor/alveolar volume) in femalesversusmales: Table 1

Hughes¹,

Pride²

2003

Eur Respir J

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“…The TL,CO testing was done with a Gould 2100 automated system (Sensor Medics BV, Bilthoven, the Netherlands), using a gas mixture that contained 10% helium, 0.3% carbon monoxide, 21% oxygen, and a balance of nitrogen. The breath-holding time was preset to 10 s and the wash-out volume to 0.75 L. The dead space of the sample bag was 6.25 mL [12]. Each subject9s height was measured in stocking feet to the nearest cm.…”

Section: Spirometric and Diffusing Capacity Of Carbon Monoxide Measurmentioning

confidence: 99%

“…The equipment, as well as the standardized procedure, have been described in detail previously [12,13]. The TL,CO testing was done with a Gould 2100 automated system (Sensor Medics BV, Bilthoven, the Netherlands), using a gas mixture that contained 10% helium, 0.3% carbon monoxide, 21% oxygen, and a balance of nitrogen.…”

Section: Spirometric and Diffusing Capacity Of Carbon Monoxide Measurmentioning

confidence: 99%

“…The reference equations for TL,CO used in this analysis were derived from a segment of healthy subjects who had never smoked, taken from a randomly selected population on the south-western coast of Norway, and were as follows [12] [15]. The prevalence of bronchial asthma and chronic obstructive lung disease in this general population was 2.4% and 5.4%, respectively [11], while 29% of the subjects reported having been occupationally dust or gas exposed [11].…”

Section: Spirometric and Diffusing Capacity Of Carbon Monoxide Measurmentioning

confidence: 99%

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Increased circulating levels of α₁-antitrypsin and calprotectin are associated with reduced gas diffusion in the lungs

Welle

Bakke²,

Eide³

et al. 2001

Eur Respir J

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The aim was to examine the relationship of serum inflammatory markers to the level of single-breath diffusing capacity of carbon monoxide (TL,CO).A stratified sample (n=1,121) of a Norwegian general population aged 18–73 yrs was examined. The inflammatory markers measured were calprotectin, a prominent protein in the cytosol fraction of neutrophil granulocytes, and α1-antitrypsin (α1-AT), the major inhibitor of neutrophil elastase in the lower respiratory system. Both markers have increased circulating levels in the course of an acute inflammatory reaction.Subjects with a TL,CO<80% of predicted value had a higher level of both α1-AT (p=0.003) and calprotectin (p<0.03) than those with a TL,CO>100%. In multiple linear regression analyses, α1-AT was still significantly associated withTL,COafter adjusting for sex, age, smoking habits, haemoglobin, carboxyhaemoglobin, forced expiratory volume in one second and alveolar volume. In a similar analysis, no significant overall association was found between calprotectin and TL,CO, but in a stratified analysis, calprotectin was significantly related to TL,COin females. However, no significant sex interaction in the relationship between the inflammatory markers and TL,COwas found.The findings suggest that increased levels of α1-antitrypsin and of calprotectin are risk factors for decreased diffusing capacity of carbon monoxide.

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Single breath transfer factor for carbon monoxide in an asymptomatic population of never smokers.

Cited by 35 publications

References 19 publications

Pulmonary function one and four years after a deep saturation dive.

Pulmonary function one and four years after a deep saturation dive.

Carbon monoxide transfer coefficient (transfer factor/alveolar volume) in femalesversusmales: Table 1

Increased circulating levels of α₁-antitrypsin and calprotectin are associated with reduced gas diffusion in the lungs

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Single breath transfer factor for carbon monoxide in an asymptomatic population of never smokers.

Cited by 35 publications

References 19 publications

Pulmonary function one and four years after a deep saturation dive.

Pulmonary function one and four years after a deep saturation dive.

Carbon monoxide transfer coefficient (transfer factor/alveolar volume) in femalesversusmales: Table 1

Increased circulating levels of α1-antitrypsin and calprotectin are associated with reduced gas diffusion in the lungs

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Increased circulating levels of α₁-antitrypsin and calprotectin are associated with reduced gas diffusion in the lungs