Single-cell immune atlas for human aging and frailty

Leng, Sean X.; Pawelec, Graham

doi:10.1093/lifemedi/lnac013

Cited by 22 publications

(11 citation statements)

References 10 publications

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“…With the development and innovation of the latest highthroughput omics technology of single-cell sequencing, a lot of studies are devoted to age-related diseases and extending a healthy lifespan (Leng and Pawelec, 2022;Tabula Muris, 2020;Wen and Tang, 2022;Wu et al, 2023;Zhang et al, 2022a;Zhou et al, 2022). Numerous biomarkers have been proposed to understand and measure these processes.…”

Section: Aging Clocks At Single-cell Resolutionmentioning

confidence: 99%

Biomarkers of aging

Bao

Cao

Chen

et al. 2023

Sci. China Life Sci.

153

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Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitations remain poorly characterized. An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research: How old are we? Why do we get old? And how can we age slower? This review aims to address this need. Here, we summarize our current knowledge of biomarkers developed for cellular, organ, and organismal levels of aging, comprising six pillars: physiological characteristics, medical imaging, histological features, cellular alterations, molecular changes, and secretory factors. To fulfill all these requisites, we propose that aging biomarkers should qualify for being specific, systemic, and clinically relevant. Supporting Information The supporting information is available online at 10.1007/s11427-023-2305-0. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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Section: Aging Clocks At Single-cell Resolutionmentioning

confidence: 99%

Biomarkers of aging

Bao

Cao

Chen

et al. 2023

Sci. China Life Sci.

153

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“…Since both aging and exercise involve distinct organs, tissues, and cell types, 4 , 6 , 21 , 22 , 23 , 24 a systemic and integrative study across multiple tissues, dissecting the molecular programs in tissue- and cell type-specific manner, is of critical importance. 25 , 26 , 27 , 28 , 29 In the past few years, high-throughput single-cell transcriptomes have been constructed for aging and its interventions, 30 , 31 , 32 such as caloric restriction and heterochronic parabiosis in mammalian species, 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 providing unprecedented resolution of the cellular and molecular changes in aged animals. However, whether and how exercise rewires the transcriptome at the systemic level, especially in aged animals, remains largely unexplored.…”

Section: Introductionmentioning

confidence: 99%

A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body

Sun¹,

Ma²,

Cai³

et al. 2023

The Innovation

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“…Aging is a complex physiological process accompanied by the development of aging-related diseases such as inflammatory and autoimmune diseases, cancers, infections, and neurodegenerative disorders (Calcinotto et al, 2019;Ma et al, 2021;Wang et al, 2021b;Zheng et al, 2020). One of the major pathogenic factors is immune senescence-induced dysfunction, which promotes the responses to self-antigens whereas weakens the body's resistance to foreign antigens and tumor cells, thereby increasing the risk of aging-related diseases (Calcinotto et al, 2019;Leng and Pawelec, 2022). This immune dysfunction due to increased age is defined as physiological immune senescence (PHIS).…”

Section: Aging and Immune Senescencementioning

confidence: 99%

The landscape of aging

Cai

Song

et al. 2022

Sci. China Life Sci.

200

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Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased susceptibility to death. It is a major risk factor for chronic human diseases, including cardiovascular disease, diabetes, neurological degeneration, and cancer. Therefore, the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences. In recent years, there has been unprecedented progress in aging research, particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes. In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases, we review the descriptive, conceptual, and interventive aspects of the landscape of aging composed of a number of layers at the cellular, tissue, organ, organ system, and organismal levels.

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Single-cell immune atlas for human aging and frailty

Cited by 22 publications

References 10 publications

Biomarkers of aging

Biomarkers of aging

A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body

The landscape of aging

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