“…Studies in peripheral blood mononuclear cells [119], fibroblasts [78], tumor samples [59], and pluripotent and differentiating cells [15, 23, 42, 78] found several eQTLs that would have been missed in bulk sequencing approaches due to being active in only one or a few cell types. While in many single-cell studies most of the detected eQTLs were only found in a single cell type [44, 56, 78], this likely overestimates the overall cell-type specificity of genetic effects on gene expression due to incomplete power of eQTL discovery in these datasets [81]. Previous approaches have successfully mapped the genetic determinants of responses to infection, drugs, and other stimuli [2, 7, 12, 25, 37, 39, 47, 48, 49, 51, 61, 62, 64, 77, 79, 89, 97, 104, 125] using bulk RNA-seq.…”