Single-copy flanking sequences in human histone gene clusters map to chromosomes 1 and 6

Allen, Beverly Steele; Stein, Janet L.; Ostrer, Harry

doi:10.1016/0888-7543(91)90337-e

Cited by 26 publications

(15 citation statements)

References 6 publications

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“…The genes encoding the core histone proteins are tightly linked in all metazoans that have been studied. In mammals there are two clusters of replicationdependent histone genes, located on separate chromosomes: chromosomes 1 and 6 in human (Triputti et al 1986;Allen et al 1991) and chromosomes 3 and 13 in mouse (Graves et al 1985). To understand the overall organization of the histone genes, we undertook the isolation of the entire histone gene cluster.…”

Section: Resultsmentioning

confidence: 99%

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Characterization of the mouse histone gene cluster on chromosome 13: 45 histone genes in three patches spread over 1Mb.

Wang¹,

Krasikov²,

Frey³

et al. 1996

Genome Res.

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The histone gene cluster on mouse chromosome 13 has been isolated and characterized. Using overlapping YAC clones containing histone genes from chromosome 13, a contig of -2 Mb has been defined, it contains 45 histone genes, organized in three patches containing tightly clustered genes. An 80-kb patch {patch I!I} containing 12 histone genes is near one end of the contig, and a similar-sized patch {patch i} containing 15 histone genes is near the other end of the contig, located at least 500 kb from the central patch {patch I1} of histone genes. The entire cluster contains six histone HI genes, including the testis-specific histone Hit gene that maps to the middle of the cluster. All nine histone H3 genes in this cluster have been sequenced, and their level of expression determined. Each histone H3 gene is distinct, with five genes encoding the H3.2 protein subtype and four genes encoding the H3.1 protein. They are all expressed, with each histone H3 gene accounting for a small proportion of the total histone H3 mRNA.

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Section: Resultsmentioning

confidence: 99%

“…Whether any of these histone variants have distinct functions is not known. The histone genes in mammals are located on two chromosomes, chromosomes 1 and 6 in human (Triputti et al 1986;Allen et al 1991), and chromosomes 3 and 13 in mouse (Graves et al 1985). Most of the histone genes in the mouse are located on chromosome 13 (Graves et al 1985).…”

mentioning

confidence: 99%

Characterization of the mouse histone gene cluster on chromosome 13: 45 histone genes in three patches spread over 1Mb.

Wang¹,

Krasikov²,

Frey³

et al. 1996

Genome Res.

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“…During the S-phase of the cell cycle, large amounts of histones need to be produced to pack the newly synthesized DNA. In order to increase histone protein abundance, gene duplication, as also observed in mammalian genomes, provides a biological alternative compared with increased rates of transcription (Graves et al, 1985;Tripputi et al, 1986;Allen et al, 1991). Apart from sufficient histone proteins in rapidly dividing cells, exact quantities also are required for correct nucleosome formation.…”

Section: Data Analysis: Dissecting Plant Gene Duplicates Using Plazamentioning

confidence: 99%

PLAZA: A Comparative Genomics Resource to Study Gene and Genome Evolution in Plants

et al. 2009

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The number of sequenced genomes of representatives within the green lineage is rapidly increasing. Consequently, comparative sequence analysis has significantly altered our view on the complexity of genome organization, gene function, and regulatory pathways. To explore all this genome information, a centralized infrastructure is required where all data generated by different sequencing initiatives is integrated and combined with advanced methods for data mining. Here, we describe PLAZA, an online platform for plant comparative genomics (http://bioinformatics.psb.ugent.be/plaza/). This resource integrates structural and functional annotation of published plant genomes together with a large set of interactive tools to study gene function and gene and genome evolution. Precomputed data sets cover homologous gene families, multiple sequence alignments, phylogenetic trees, intraspecies whole-genome dot plots, and genomic colinearity between species. Through the integration of high confidence Gene Ontology annotations and tree-based orthology between related species, thousands of genes lacking any functional description are functionally annotated. Advanced query systems, as well as multiple interactive visualization tools, are available through a user-friendly and intuitive Web interface. In addition, detailed documentation and tutorials introduce the different tools, while the workbench provides an efficient means to analyze user-defined gene sets through PLAZA's interface. In conclusion, PLAZA provides a comprehensible and up-to-date research environment to aid researchers in the exploration of genome information within the green plant lineage.

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“…Two well-studied histone H4 promoters were fused independently to a luciferase gene reporter, and the effects of NPAT on transcription from these H4 promoters were assayed in transient transfec- tion experiments. One reporter construct, pGLH4-1, contains the promoter sequence of the F0108 H4 gene, which is located on chromosome 1 (Allen et al 1991;Ramsey-Ewing et al 1994;van Wijnen et al 1992van Wijnen et al , 1996Albig and Doenecke 1997). The other reporter construct, pGLH4, has the promoter sequence of the pHu4A (H4/e) gene, which is located on chromosome 6 (Hanly et al 1985;Dailey et al 1987Dailey et al , 1988Albig and Doenecke 1997).…”

Section: Npat Activates Histone Gene Transcriptionmentioning

confidence: 99%

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

Zhao¹,

Kennedy²,

Lawrence³

et al. 2000

Genes Dev.

617

477

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In eukaryotic cells, histone gene expression is one of the major events that mark entry into S phase. While this process is tightly linked to cell cycle position, how it is regulated by the cell cycle machinery is not known. Here we show that NPAT, a substrate of the cyclin E-Cdk2 complex, is associated with human replication-dependent histone gene clusters on both chromosomes 1 and 6 in S phase. We demonstrate that NPAT activates histone gene transcription and that this activation is dependent on the promoter elements (SSCSs) previously proposed to mediate cell cycle-dependent transcription. Cyclin E is also associated with the histone gene loci, and cyclin E-Cdk2 stimulates the NPAT-mediated activation of histone gene transcription. Thus, our results both show that NPAT is involved in a key S phase event and provide a link between the cell cycle machinery and activation of histone gene transcription.

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Single-copy flanking sequences in human histone gene clusters map to chromosomes 1 and 6

Cited by 26 publications

References 6 publications

Characterization of the mouse histone gene cluster on chromosome 13: 45 histone genes in three patches spread over 1Mb.

Characterization of the mouse histone gene cluster on chromosome 13: 45 histone genes in three patches spread over 1Mb.

PLAZA: A Comparative Genomics Resource to Study Gene and Genome Evolution in Plants

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcription

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