Single dose doxycycline therapy for scrub typhus

Brown, G.W.; Saunders, J. P.; Singh, Sunita; Huxsoll, David L.; Shirai, Akira

doi:10.1016/0035-9203(78)90138-4

Cited by 64 publications

(44 citation statements)

References 15 publications

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“…In patients treated with doxyCycline (100 mg/12 h) for two days fever subsided after 2.5 _+ 1.1 days (15). The period required to achieve apyrexia with doxycycline in that study is similar to that in our trial (60 h vs. 55.2 h) and corroborates the notion that short-term regimens of doxycycline are as efficient as prolonged administration in controlling fever in MSE Likewise good results have been obtained with a single close (17) or short-term regimens of doxycycline in MSF (18,19) and other rickettsioses such as epidemic typhus (20, 21) and scrub typhus (22). A greater discrepancy was seen in the results with ciprofloxacin: in our patients, who were treated with 750 mg/12 h for one week, apyrexia was achieved in 50.1 h, whereas in the above mentioned study using a ciprofloxacin dosage of 500 mg/12 h for two days fever subsided in 91.2 h (15).…”

Section: Discussionsupporting

confidence: 93%

Evaluation of ciprofloxacin and doxycycline in the treatment of mediterranean spotted fever

Beltran

Herrero

1992

Eur. J. Clin. Microbiol. Infect. Dis.

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A comparison was made of the results obtained with ciprofloxacin (750 mg/12 h) and doxycycline (100 mg/12 h), both administered p.o. for one week, in 34 and 36 patients respectively with Mediterranean spotted fever. Apyrexia was achieved after 50.1 +/- 34.2 h (mean +/- SD) of antibiotic therapy in the group of patients treated with ciprofloxacin and in 55.2 +/- 23.3 h in the group treated with doxycycline (no significant statistical differences). Resolution of the remaining signs and symptoms of the disease was achieved faster with ciprofloxacin. Both therapeutic regimens were effective and safe. Although more expensive than doxycycline, ciprofloxacin is a bactericidal compound which is better tolerated and has a lower risk of toxicity and of development of resistance. It can be considered, together with doxycycline, as an antibiotic of first choice in the treatment of Mediterranean spotted fever.

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Section: Discussionsupporting

confidence: 93%

Evaluation of ciprofloxacin and doxycycline in the treatment of mediterranean spotted fever

Beltran

Herrero

1992

Eur. J. Clin. Microbiol. Infect. Dis.

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“…By contrast, patients treated with appropriate antibiotics typically become afebrile within 48 hours of starting therapy 15,16,17 . This response to treatment may be useful diagnostically; failure of defervescence within 48 hours is often considered evidence that scrub typhus is not present, and that an alternate diagnosis such as malaria or dengue should be considered.…”

Section: Discussionmentioning

confidence: 99%

Case Report of Scrub Typhus

Rabbani¹,

Hossain²,

Begum³

2018

J. Bangladesh Coll. Phys.

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Scrub typhus is an acute, febrile, infectious illness that is caused by Orientia tsutsugamushi. Scrub and murine endemic typhus infections are under-diagnosed causes of febrile illness across the tropics, and it is not known how common they are in Bangladesh. Here reporting a case who presented with high grade fever for 7 days associated with headache, abdominal discomfort, cough and receiving inj ceftriaxone for 2 days considering as a case of enteric fever. Forty-eight hours after admission, the presence of continued high grade fever, conjunctival congestion, headache, loose motion, cough, low platelet, elevated transaminase raised the possibility of a different aetiology. The two most likely differentials being dengue and malaria.

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“…Die antibiotische Therapie sollte bei begründetem Verdacht umgehend begonnen werden. Bereits eine Einmaldosis von 200mg Doxycyclin erwies sich als wirksam (3). Zur Vermeidung von Rückfällen und bei schwereren Erkrankungen ist jedoch eine Dosierung von 100mg zweimal täglich über 7-10 Tage empfehlenswert (13).…”

Section: Therapie Und Prophylaxeunclassified

Tsutsugamushi-Fieber nach Südostasienreise

Seilmaier

Guggemos²,

Böhme³

et al. 2004

Dtsch med Wochenschr

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In febrile travellers returning from Southeast Asia, Tsutsugamushi fever has to be considered in the differential diagnosis. The causative agent, Orienta tsutsugamushi is transmitted by larvae of trombiculid mites (chiggers). Leading symptoms are fever continua, cephalgia, and a primary lesion (eschar) at the site of cutaneous inoculation. The Eschar is easily overlooked and has to be searched carefully. Diagnosis is confirmed by the detection of specific antibodies. However, serology may be negative in the beginning. Therefore, treatment with doxycycline should be initiated on clinical grounds.

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Single dose doxycycline therapy for scrub typhus

Cited by 64 publications

References 15 publications

Evaluation of ciprofloxacin and doxycycline in the treatment of mediterranean spotted fever

Evaluation of ciprofloxacin and doxycycline in the treatment of mediterranean spotted fever

Case Report of Scrub Typhus

Tsutsugamushi-Fieber nach Südostasienreise

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