Single dose of two grams of metronidazole for Trichomonas vaginalis infection

Fleury, Frederick J.; Bergen, William S. Van; Prentice, Robert L.; Russell, James; Singleton, James A.; Standard, John V.

doi:10.1016/0002-9378(77)90630-5

Cited by 36 publications

(4 citation statements)

References 4 publications

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“…The alternative treatment regimen is MTZ 500 mg orally twice a day (BID) for 7 days 16. The studies supporting the use of the single 2 gm MTZ dose as the primary treatment regimen, however, were conducted with mostly non-HIV infected women 17-24. Given the high rates of repeat infections, and the mounting evidence that many of these repeat infections are due to treatment failure, the MTZ 2 gm single dose may not be adequate for HIV-infected women.…”

Section: Introductionmentioning

confidence: 99%

A Randomized Treatment Trial: Single Versus 7-Day Dose of Metronidazole for The Treatment of Trichomonas Vaginalis Among HIV-Infected Women

Kissinger¹,

Mena²,

Levison³

et al. 2010

JAIDS Journal of Acquired Immune Deficiency Syndromes

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Objective To determine if the metronidazole (MTZ) 2 gm single dose (recommended) is as effective as the 7 day 500 mg BID dose (alternative) for treatment of Trichomonas vaginalis (TV) among HIV+ women. Methods Phase IV randomized clinical trial; HIV+ women with culture confirmed TV were randomized to treatment arm: MTZ 2 gm single dose or MTZ 500 mg BID 7 day dose. All women were given 2 gm MTZ doses to deliver to their sex partners. Women were re-cultured for TV at a test-of-cure (TOC) visit occurring 6-12 days after treatment completion. TV-negative women at TOC were again re-cultured at a 3 month visit. Repeat TV infection rates were compared between arms. Results 270 HIV+/TV+ women were enrolled (mean age = 40 years, ± 9.4; 92.2% African-American). Treatment arms were similar with respect to age, race, CD4 count, viral load, ART status, site, and loss-to-follow up. Women in the 7 day arm had: lower repeat TV infection rates at TOC [8.5% (11/130) versus 16.8% (21/125) (R.R. 0.50, 95% CI=0.25, 1.00; P<0.05)], and at 3 months [11.0% (8/73) versus 24.1% (19/79) (R.R. 0.46, 95% CI=0.21, 0.98; P=0.03)] compared to the single dose arm. Conclusions The 7 day MTZ dose was more effective than the single dose for the treatment of TV among HIV+ women.

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Section: Introductionmentioning

confidence: 99%

A Randomized Treatment Trial: Single Versus 7-Day Dose of Metronidazole for The Treatment of Trichomonas Vaginalis Among HIV-Infected Women

Kissinger¹,

Mena²,

Levison³

et al. 2010

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…The treatment outcome in this study following the 2-g dose was similar to that reported previously in which cure rates ranged from approximately 80070 to 957o. '14 [7][8][9][10][11] The latter figure occurred in a clinic population where reinfection as a cause of treatment failure was recognised and apparently eliminated.8 The proportion of treatment failures that were actually due to reinfection in our study, despite treatment of the principal male consorts and explicit instructions to the patients to avoid sexual intercourse, is unknown.…”

Section: Discussionmentioning

confidence: 93%

Metronidazole in a single dose for the treatment of trichomoniasis. Failure of a 1-g single dose.

Austin¹,

Smith²,

Darwish³

et al. 1982

Sexually Transmitted Infections

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SUMMARY To determine the minimum effective dose of metronidazole in the treatment of vaginal trichomoniasis, a randomised clinical trial comparing single 1-g and 2-g doses was carried out on 163 patients attending sexually transmitted diseases and family planning clinics. Seventytwo of 86 (84q7o) patients receiving a single 2-g dose of metronidazole were cured compared with only 42 of 77 (5507) receiving a 1-g dose. The body weight of the patient was a significant variable affecting treatment outcome only in the latter group; 69% of patients weighing more than 57 kg or less were cured compared with only 43% of those weighing more. Patients who failed after either dose regimen were retreated with a single 2-g dose. Eighteen of 21 (86%7o) and seven of 10 (70%) failures with the initial 1-g and 2-g doses respectively were cured. A single 1-g dose of metronidazole is not recommended as routine treatment for vaginal trichomoniasis.

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“…But in 7 days treatment 3 patients i.e., 2 females and 1 male had vomitings, after taking this drug. In other studies clinical trial reports on metronidazole indicate that a single oral dose of 2 gm cured trichomoniasis in over 95% of cases when sexual partners are simultaneously treated (8,9,10,11).…”

Section: Response With Metronidazole:-mentioning

confidence: 92%

A Retrospective cohort study on incidence of Trichomoniasis in high risk group patients with Leucorrhoea at RIMS General Hospital, Srikakulam.

KG¹,

Satyanarayana²

2016

IJAR

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Background: Trichomoniasis becomes an epidemic in nearly all countries of the world during the past four decades. It has been noted that it has major impact on the maternal and infant morbidity and on human reproduction and infertility. Leucorrhoea is one of the common complaints encountered in Obstetric & Gynaecology and STD departments. The pathogens, which were frequently blamed for this type of abnormal vaginal discharge are T.vaginalis, candida species and Gardnerella vaginalis. Out of these three causes, T.vaginalis vaginitis is probably the most common cause among women afflicted with STD. The true incidence of trichomoniasis in our population is unknown. Hence we conducted a retrospective cohort study on incidence of Trichomoniasis in high risk group patients with Leucorrhoea attending OPD at RIMS General Hospital, Srikakulam. Objective: To evaluate the true incidence of Trichomoniasis in high risk groups attending the OPD with Leucorrhoea. Patients and methods: A retrospective analysis of 300 cases of vaginal discharge who attended themselves to the OPD and those who had not received any specific anti-trichomonal drug. T.vaginalis was isolated by a wet-mount examination and by culture. Results: We got 17.67% of incidence in our patient population. We observed a high incidence among the following , Between 15 and 29 years of age. , with a low socio economic status and ,In pregnant females. Most of the patients were the victims of sexually promiscuous husbands. Conclusion: In our study,T.vaginalis was isolated in 53 cases of vaginal discharge by a wet mount examination and by culture. But we had poor culture results with Kupferberg's trichomonas broth base medium and the poor culture results made us to depend completely on the wet mount examination. So, we prefer wet mount examination to culture in identification of T.vaginalis.

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Single dose of two grams of metronidazole for Trichomonas vaginalis infection

Cited by 36 publications

References 4 publications

A Randomized Treatment Trial: Single Versus 7-Day Dose of Metronidazole for The Treatment of Trichomonas Vaginalis Among HIV-Infected Women

A Randomized Treatment Trial: Single Versus 7-Day Dose of Metronidazole for The Treatment of Trichomonas Vaginalis Among HIV-Infected Women

Metronidazole in a single dose for the treatment of trichomoniasis. Failure of a 1-g single dose.

A Retrospective cohort study on incidence of Trichomoniasis in high risk group patients with Leucorrhoea at RIMS General Hospital, Srikakulam.

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