Single dose oral diflunisal for acute postoperative pain in adults

Abstract

Background-Diflunisal is a long-acting non-steroidal anti-inflammatory drug (NSAID) most commonly used to treat acute postoperative pain or chronic joint pain from osteoarthritis and rheumatoid arthritis. This review analyses the effectiveness and harm of different doses of diflunisal in the context of moderate to severe postoperative pain.

Engineering a selective fluorescent sensor with a high signal-to-background ratio for microalbumin detection and imaging

“…Selective detection of the drug DIF based on the FNE3-HSA fluorescent complex Diflunisal (DIF), a class of salicylic acid derivatives among nonsteroidal anti-inflammatory drugs (NSAIDs), 39 is widely used in clinical trials for the treatment of inflammation, analgesia, and pain, such as in osteoarthritis, rheumatoid arthritis, and primary dysmenorrhea. 40 The recommended daily dose for clinical treatment is 500 mg to 1000 mg. 41 However, overdose of DIF has been reported to result in various side effects, such as renal failure, gastrointestinal bleeding, and hypertension. 42,43 Accordingly, monitoring DIF concentrations is critical for instructing its safe use and studying pharmacokinetics in clinical practice.…”